EKFZ Publikationen
Im Rahmen der Forschungstätigkeit am Else Kröner Fresenius Zentrum (EKFZ) werden Studienergebnisse in verschiedenen wissenschaftlichen Zeitschriften veröffentlicht. Publikationen der einzelnen Forschungsbereiche "(Klinische) Ernährungsmedizin" [kurz: KEM], "Molekulare Ernährungsmedizin" [kurz: MEM]und "Pädiatrische Ernährungsmedizin"[kurz: PEM] sind nachfolgend aufgelistet. Abgesehen von diesen Originalarbeiten werden Beiträge für Kongresse, in Büchern oder als Übersichtsarbeiten bzw. Editorials veröffentlicht. Auf Nachfrage können diejenigen Artikel bei den einzelnen Lehrstühlen bzw. Instituten eingesehen werden, die nicht in der Liste enthalten sind.
Klinische Ernährungsmedizin
2022
Staudigel M, Brandl B, Roosen J, Kiesswetter E, Siebentritt HM, Skurk T, Volkert D, Hauner H. Association of eating motives with anthropometry, body composition, and dietary intake in healthy German volunteers – an enable study. Appetite 2022 March 1;170:105865, doi: 10.1016/j.appet.2021.105865. PMID:34921914
Kaiser B, Gemesi K, Holzmann SL, Wintergerst M, Lurz M, Hauner H, Groh G, Böhm M, Krcmar H, Holzapfel C, Gedrich K. Stress-induced overeating: empirical characterization of stress eaters. BMC Publ Health 2022 Jan 14;22(1):100, doi: 10.1186/s12889-021-12488-9. PMID: 35031050
Held C, Junker D, Wu M, Patzelt L, Mengel L, Holzapfel C, Diefenbach MN, Makowski MR, Hauner H, Karampinos DC. Intraindividual difference between supraclavicular and subcutaneous PDFF is associated with cold-induced thermogenesis in adults. Quant Imag Med Surg 2022 May 12(5):2877-2890, doi: 10.21037/qims-21-986. PMID: 35502400
Mengel L, Nemati Moud B, Seidl H, Mesas Fernandez A, Seeliger C, Brandl B, Skurk T, Holzapfel C, Claussnitzer M, Hauner H. Effect of BMI on the thermogenic response to cold exposure and associated changes in metabolism and browning markers. Obes Facts 2022 Jan 26, doi: 10.1159/000522218. PMID: 35081533
Brandl B, Rennekamp R, Reitmeier S, Pietrynik K, Dirndorfer S, Haller D, Hofmann T, Skurk T, Hauner H. Offering fiber-enriched foods increases fiber intake in adults with and without cardiometabolic risk: a randomized controlled trial. Front Nutr 2022 Feb 16;9:816299, doi: 10.3389/fnut.2022.816299. PMID: 35252300
Schicker D, Blankenagel S, Zimmer C, Hauner H, Freiherr J. Less is more: Removing a stimulus modality of a expected olfactory-visual stimulation enhances actication in multisensory brain areas. Human Brain Mapping 2022;43:2567-2581, doi: 10.1002/hbm.25806. PMID:35142405
Drabsch T, Junker D, Stecher L, Hauner H, Karampinos D, Holzapfel C. Association between proton density fat fraction, resting metabolic rate and FTO genotype in humans. Front Endocrinol 2022 Febr 28, doi:10.3389/fendo.2022.804874. PMID: 35295982
Geyer K, Günther J, Spies M, Raab R, Hauner H. Nährstoffsupplementierung in der Schwangerschaft und Stillzeit: eine Analyse der “Gesund Leben in der Schwangerschaft”-Studie. Geburtshilfe Frauenheilk 2022 May;82(7):736-746, doi: 10.1055/a-1771-6368. PMID: 35815097
Spies M, Geyer K, Raab R, Brandt S, Meyer D, Günther J, Hoffmann J, Hauner H. Child anthropometrics and neurodevelopmentat 2 and 3 years of age following a pregnancy lifestyle interventionin routine care – a secondary analysis from the cluster-randomized GeLiS Trial. J Clin Med 2022,11,1688, doi.org/10.3390/jcm11061688. PMID: 35330013
Chareh N, Kiesswetter E, Kob R, Hannink A, Brandl B, Skurk T, Hauner H, Sieber CC, Volkert D. Association between inflammation and appetite in healthy community-dwelling older adults – an enable study. Front Aging 2022 March 18;3:826816, doi.10.3389/fragi.2022.820816. PMID: 15821805
Gemesi K, Holzmann SL, Kaiser B, Wintergerst M, Lurz M, Groh G, Böhm M, Krcmar H, Gedrich K, Hauner H, Holzapfel C. Stress-induced eating, comfort foods, and their substitutes – an online survey in adults in Germany. BMC Public Health 2022 Febr 24;22:391, doi.org/10.1186/s12889-022-12787-9. PMID: 35546927
Raab R, Hoffmann J, Geyer K, Spies M, Meyer D, Günther J, Hauner H. Pre- and early pregnancy lifestyle factors predict the risk of preterm birth – a secondary analysis of the cluster-randomized GeLiS Trial. BMC Pregnancy Childbirth 2022;20:230, doi.org/10.1186/s12884-022-04513-5. PMID: 35313852
Lisitsyna A, Moritz F, Liu Y, Al Sadat L, Hauner H, Claussnitzer M, Schmitt-Kopplin P, Forcisi S. Feature selection pipeline with classification for non-targeted metabolomics combining neural network and genetic algorithm. Anal Chem 2022 April12;94:5474-5482, doi.org/10.1021/acs.analchem.1c03237. PMID: 35344349
Honecker J, Ruschke S, Seeliger C, Laber S, Strobel S, Pröll P, Nellaker C, Lindgren CM, Kulozik K, Ecker J, Karampinos DC, Claussnitzer M, Hauner H. Transcriptome and fatty-acid signatures of adipocyte hypertrophy and its non-invasive MR-based characterization in human adipose tissue. eBioMedicine 2022;79:104020, doi.org/10.1016/j.ebiom.2022.104020. PMID: 35490555
Kowall B, Kostev K, Landgraf R, Hauner H, Bierwirth R, Rathmann W. Effects of the COVID-19 pandemic on clinically diagnosed psychiatric diseases in persons with type 2 diabetes. Diabet Med 2022 April 15:e14852, doi: 10.1111/dme.14852. PMID: 35426166
Friedrichs P, Hauner H, Schmidt K. Lebenssituation und Versorgung von Menschen mit Diabetes mellitus: ein Scoping Review zu den Auswirkungen der COVID-19-Pandemie in Deutschland. Diabetol Stoffw 2022, doi: 10.1055/a-1837-2153.
Siebentritt HM, Kiesswetter E, Hannink A, Brandl B, Skurk T, Wawro N, Linseisen J, Hauner H, Volkert D. Subjektive Bewertung und Beachtung einzelner Aspekte einer gesundheitsförderlichen Ernährung bei rüstigen älteren Menschen. Ernährungs Umschau 2022;69(4):40-47, doi: 10.4455/eu.2022.011. PMID:
Dei J, Dressel K, Eisner P, Roosen J, Hauner H. Die Food Start-up-Szene im Großrtaum München. Ein Vergleich zwischen 2020 und 2017. Ernährungs Umschau 2022;69(7):112-117, doi: 10.4445/eu.2022.020
Matchado M, Dietrich A, Zwiebel M, Ölke B, Lauber M, Lagkouvardos I, Baumbach J, Haller D, Brandl B, Skurk T, Hauner H, Reitmeier S, List M. Namco: a microbiome explorer. Microbial Genomics 2022 Aug:8(8), doi: 10.1099/mgen.0.000852. PMID: 35917163
Seeliger C, Krauss T, Honecker J, Mengel L, Buekens L, Mesas-Fernandez AS, Skurk T, Claussnitzer M, Hauner H. miR-375 is cold exposure sensitive and drives thermogenesis in visceral adipose tissue derived stem cells. Scient Rep 2022 June 10;12(1):9557, doi: 10.1038/s41598-022-13610-6. PMID: 35688898
Reik A, Brandl B, Schauberger G, Wawro N, Linseisen J, Skurk T, Volkert D, Hauner H, Holzapfel C. Association between habitual diet consumption and postprandial glucose response – an enable study. Mol Nutr & Food Res 2022 June 17:e2200110, doi: 10.1002/mnfr.202200110. PMID: 35713029
Dahal C, Wawro N, Meisinger C, Brandl B, Skurk TS, Volkert D, Hauner H, Linseisen J. Evaluation of the metabotype concept after intervention with oral glucose tolerance test and dietary fiber-enriched food: an enable study. Nutr Metab Cardiovasc Dis 2022, June 18;S0939-4753(22)00257-5, doi: 10.1016/j.numecd.2022.06.007. PMID: 35850752
Fiamoncini J, Rist MJ, Frommherz L, Giesbertz P, Pfrang B, Kremer W, Huber F, Skurk T, Hauner H, Kastenmüller G, Suhre K, Daniel H, Kulling S. Dynamics and determinants of human plasma bile acid profiles during dietary challenges. . PMID: July28;9:932937, doi: 10.3389/fnut.2022.932937. PMID: 35967802
Schicker D, Karacan B, Brandl B, Skurk T, Volkert D, Hauner H, Freiherr J. Bloody olfaction? Confounding effects of sex and age on the influence of blood parameters and body weight on odor identification performance in healthy adults. Physiol & Behav 2022 July 8:113907. PMID: 35817126
Hellbach F, Baumeister S-E, Wilson R, Wawro N, Dahal C, Freuer D, Hauner H, Peters A, Winkelmann J, Schwettmann L, Rathmann W, Kronenberg F, Koenig W, Meisinger C, Waldenberger M, Linseisen J. Association between usual dietary intake of food groups and DNA methylation and effect modification by metabotype. Life 2022, 12, 1064. doi.org/10.3390/life12071064. PMID: 35888152
Weinisch P, Fiamoncini J, Schranner D, Raffler J, Skurk T, Rist M, Römisch-Margl W, Prehn C, Adamski J, Hauner H, Daniel H, Suhre K, Kastenmüller G. Dynamic patterns of postprandial metabolic responses to three dietary challenges. Front Nutr 2022;9:933526, doi: 10.3389/fnut.2022.933526. PMID: 36211489
Leonhardt Y, Dieckmeyer M, Zoffl F, Feuerriegel G, Sollmnn N, Junker D, Greve T, Holzapfel C, Hauner H, Subburaj K, Kirschke J, Karampinos DC, Zimmer C, Makowski MR, Baum T, Burian E. Association of texture features of proton density fat fraction maps from chemical shift encoding-based MRI between lumbar vertebral bone marrow and paraspinal musculature. Biomedicines 2022 Aug 25,10,2075, doi.org/10.3390/biomedicines10092075. PMID: 36140176
Dahal C, Wawro N, Meisinger C, Breuninger TA, Thorand B, Rathmann W, König W, Hauner H, Peters A, Linseisen J. Optimized metabotype definition based on a limited number of standard clinical parameters in the population-based KORA study. Life 2022, 12, 1460, doi.org/10.3390/life12101460. PMID: 36294895
Laber S, Strobel S, Mercader J-M, Dashti H, Ainbinder A, Honecker J, Garborcauscas G, Stirling DR, Leong A, Figueroa K, Sinnott-Armstrong N, Kost-Alimova M, Deodato G, Harney A, Way GP, Saadat A, Harken S, Reibe-Pal S, Ebert H, Zhang Y, Calabuig-Navarro V, McGonagle E, Stefek A, Dupuis S, Cimini BA, Hauner H, Udler MS, Carpenter AE, Florez JC, Lindgren CM, Jacobs SBR, Claussnitzer M. Discovering cellular programs of intrinsic and extrinsic drivers of metabolic traits using LipocyteProfiler. Cell Genomics 2022, accepted
Meyer D, Pastor-Villaescusa B, Michel S, Hauner H, Hauner D. Associations between circulating biomarkers and prognosis in female breast cancer survivors: a systematic review of observational data. BMC Cancer 2022:22;1187, doi: 10.1186/s12865-022-10274-3. PMID: 36401194
Eckfeld C, Schoeps B, Häußler D, Frädrich J, Bayerl F, Böttcher J, Knolle P, Heisz S, Prokopchuk O, Hauner H, Muukhbaatar E, Demir IE, Hermann CD, Krüger A. TIMP-1 is a novel ligand of amyloid precursor protein and triggers a pro-inflammatory phenotype in human monocytes. J Cell Biol 2022, accepted
Wagner R, Heni M, Kantartzis K, Sandforth A, Machann J, Schick F, Peter A, Fritsche L, Szendrödi J, Pfeiffer AFH, Schürmann A, Blüher M, Hauner H, Seissler J, Bornstein S, Roden M, Stefan N, Birkenfeld AL, White MF, Häring H-U, Fritsche A. Lower hepatic fat is associated with improved insulin secretion in a high-risk prediabetes subphenotype during lifestyle intervention. Diabetes 2022 Dec 16:db220441, doi: 10.2337/db22-0441. PMID:36525512
Hellbach F, Sinke L, Costeira R, Baumeister S-E, Beekman M, Louca P, Leeming ER, Mongeo O, Berry S, Wilson R, Wawro N, Freuer D, Hauner H, Peters A, Winkelmann J, Koenig W, Meisinger C, Waldenberger M, Heijmans B, Slagboom PE, Bell JT, Linseisen J. Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS. Eur J Nutr 2022 Dec 26, doi: 10.1007/s00394-022-03074-9. PMID: 36571600
Kuhaj K, Harger A, Bauer M, Caliskan ÖS, Gupta T, Chiang D, Lutter D, Kotzbeck P, Sailer DN, Reber J, Karlas A, Prakash S, Volta F, Merl-Pham J, Ntziachristos V, Hauner H, Pfaffl MW, Tschöp MH, Müller TD, Hauck SM, Engel B, Gerdes JM, Pfluger PT, Krahmer N, Stemmer K. Adipocyte derived extracellular vesicles are endocrine regulators of insulin secretion in mice. Nat Comm 2022, accepted
Daniel H, Hauner H, Hornef M, Clavel T. Allulose in human diet: the knowns and the unknowns. Br J Nutr. 2022 Jul 28;128(2):172-178. doi: 10.1017/S0007114521003172. Epub 2021 Aug 19. PMID: 34409930
Holzapfel C, Waldenberger M, Lorkowski S, Daniel H; Working Group “Personalized Nutrition” of the German Nutrition Society. Genetics and Epigenetics in Personalized Nutrition: Evidence, Expectations, and Experiences. Mol Nutr Food Res. 2022 Sep;66(17):e2200077. doi: 10.1002/mnfr.202200077. Epub 2022 Jul 10. PMID: 35770348
Wiechert M, Holzapfel C. Nutrition Concepts for the Treatment of Obesity in Adults. Nutrients. 2021 Dec 30;14(1):169. doi: 10.3390/nu14010169. PMID: 35011045; PMCID: PMC8747374
Bayer S, Holzapfel C. Carbohydrate intake - current knowledge on weight management. Curr Opin Clin Nutr Metab Care. 2022 Jul 1;25(4):265-270. doi: 10.1097/MCO.0000000000000840. PMID: 35762163
Wang Z, Emmerich A, Pillon NJ, Moore T, Hemerich D, Cornelis MC, Mazzaferro E, Broos S, Ahluwalia TS, Bartz TM, Bentley AR, Bielak LF, Chong M, Chu AY, Berry D, Dorajoo R, Dueker ND, Kasbohm E, Feenstra B, Feitosa MF, Gieger C, Graff M, Hall LM, Haller T, Hartwig FP, Hillis DA, Huikari V, Heard-Costa N, Holzapfel C, Jackson AU, Johansson Å, Jørgensen AM, Kaakinen MA, Karlsson R, Kerr KF, Kim B, Koolhaas CM, Kutalik Z, Lagou V, Lind PA, Lorentzon M, Lyytikäinen LP, Mangino M, Metzendorf C, Monroe KR, Pacolet A, Pérusse L, Pool R, Richmond RC, Rivera NV, Robiou-du-Pont S, Schraut KE, Schulz CA, Stringham HM, Tanaka T, Teumer A, Turman C, van der Most PJ, Vanmunster M, van Rooij FJA, van Vliet-Ostaptchouk JV, Zhang X, Zhao JH, Zhao W, Balkhiyarova Z, Balslev-Harder MN, Baumeister SE, Beilby J, Blangero J, Boomsma DI, Brage S, Braund PS, Brody JA, Bruinenberg M, Ekelund U, Liu CT, Cole JW, Collins FS, Cupples LA, Esko T, Enroth S, Faul JD, Fernandez-Rhodes L, Fohner AE, Franco OH, Galesloot TE, Gordon SD, Grarup N, Hartman CA, Heiss G, Hui J, Illig T, Jago R, James A, Joshi PK, Jung T, Kähönen M, Kilpeläinen TO, Koh WP, Kolcic I, Kraft PP, Kuusisto J, Launer LJ, Li A, Linneberg A, Luan J, Vidal PM, Medland SE, Milaneschi Y, Moscati A, Musk B, Nelson CP, Nolte IM, Pedersen NL, Peters A, Peyser PA, Power C, Raitakari OT, Reedik M, Reiner AP, Ridker PM, Rudan I, Ryan K, Sarzynski MA, Scott LJ, Scott RA, Sidney S, Siggeirsdottir K, Smith AV, Smith JA, Sonestedt E, Strøm M, Tai ES, Teo KK, Thorand B, Tönjes A, Tremblay A, Uitterlinden AG, Vangipurapu J, van Schoor N, Völker U, Willemsen G, Williams K, Wong Q, Xu H, Young KL, Yuan JM, Zillikens MC, Zonderman AB, Ameur A, Bandinelli S, Bis JC, Boehnke M, Bouchard C, Chasman DI, Smith GD, de Geus EJC, Deldicque L, Dörr M, Evans MK, Ferrucci L, Fornage M, Fox C, Garland T Jr, Gudnason V, Gyllensten U, Hansen T, Hayward C, Horta BL, Hyppönen E, Jarvelin MR, Johnson WC, Kardia SLR, Kiemeney LA, Laakso M, Langenberg C, Lehtimäki T, Marchand LL; Lifelines Cohort Study; Magnusson PKE, Martin NG, Melbye M, Metspalu A, Meyre D, North KE, Ohlsson C, Oldehinkel AJ, Orho-Melander M, Pare G, Park T, Pedersen O, Penninx BWJH, Pers TH, Polasek O, Prokopenko I, Rotimi CN, Samani NJ, Sim X, Snieder H, Sørensen TIA, Spector TD, Timpson NJ, van Dam RM, van der Velde N, van Duijn CM, Vollenweider P, Völzke H, Voortman T, Waeber G, Wareham NJ, Weir DR, Wichmann HE, Wilson JF, Hevener AL, Krook A, Zierath JR, Thomis MAI, Loos RJF, Hoed MD. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. Nat Genet. 2022 Sep;54(9):1332-1344. doi: 10.1038/s41588-022-01165-1. Epub 2022 Sep 7. PMID: 36071172; PMCID: PMC9470530
2021
Mank M, Hauner H, Heck AJR, Stahl B. Targeted LC-ESI-MS2 characterization of human milk oligosaccharide diversity at 6 to 16 weeks post-partum reveals clear staging effects and distinctive milk groups. Anal Bioanal Chem. 2020;412(25):6887-6907. doi:10.1007/s00216-020-02819-x. PMID: 32794008
Holzapfel C, Wiechert M, Jocher M, Mittermaier S, Hauner H. Portion Size and Energy Content of Lunch Meals when consumed outside the Home An exploratory Survey based on selected Dishes. (68) 2021, DOI: 10.4455/eu.2021.015
Burian E, Becherucci EA, Junker D, Sollmann N, Greve T, Hauner H, Zimmer C, Kirschke JS, Karampinos DC, Subburaj K, Baum T, Dieckmeyer M. Association of Cervical and Lumbar Paraspinal Muscle Composition Using Texture Analysis of MR-Based Proton Density Fat Fraction Maps. Diagnostics (Basel). 2021 Oct 18;11(10):1929. doi: 10.3390/diagnostics11101929. PMID: 34679627; PMCID: PMC8534863.
Hauner H.: Evidenz in der Ernährungstherapie bei Typ 2 Diabetes. Diabetologe. Springer Medizin Verlag GmbH. 2021. 17:687–696. Online publiziert: 29. Juni 2021
doi.org/10.1007/s11428-021-00784-2
Hauner H.: Evidenz in der Ernährungstherapie bei Typ 2 Diabetes. Diabetologe. Springer Medizin Verlag GmbH. 2021. 17:687–696. Online publiziert: 29. Juni 2021
doi.org/10.1007/s11428-021-00784-2
Burian E, Becherucci EA, Junker D, Sollmann N, Greve T, Hauner H, Zimmer C, Kirschke JS, Karampinos DC, Subburaj K, Baum T, Dieckmeyer M. Association of Cervical and Lumbar Paraspinal Muscle Composition Using Texture Analysis of MR-Based Proton Density Fat Fraction Maps. Diagnostics (Basel). 2021 Oct 18;11(10):1929. doi: 10.3390/diagnostics11101929. PMID: 34679627; PMCID: PMC8534863.
Hauner H. Adipositastherapie – legale und illegale Arzneimittel und die Zukunft [Obesity treatment-legal and illegal drugs and the future]. Internist (Berl). 2021 Sep 30. German. doi: 10.1007/s00108-021-01159-x. Epub ahead of print. PMID: 34591131.
Fritsche A, Wagner R, Heni M, Kantartzis K, Machann J, Schick F, Lehmann R, Peter A, Dannecker C, Fritsche L, Valenta V, Schick R, Nawroth PP, Kopf S, Pfeiffer AF, Kabisch S, Dambeck U, Stumvoll M, Blüher M, Birkenfeld AL, Schwarz P, Hauner H, Clavel J, Seißler J, Lechner A, Müssig K, Weber K, Laxy M, Bornstein S, Schürmann A, Roden M, de Angelis MH, Stefan N, Häring HU. Different effects of lifestyle intervention in high- and low-risk prediabetes. Diabetes. 2021 Sep 16:db210526. doi: 10.2337/db21-0526. Epub ahead of print. PMID: 34531293.
Daniel H, Hauner H, Hornef MW, Clavel T. ALLULOSE in human diet: the knowns and the unknowns. Br J Nutr. 2021 Aug 19:1-18. doi: 10.1017/S0007114521003172. Epub ahead of print. PMID: 34409930
Kowall B, Kostev K, Landgraf R, Hauner H, Bierwirth R, Rathmann W. Effects of the COVID-19 lockdown on primary health care for persons with type 2 diabetes - Results from the German Disease Analyzer database. Diabetes Res Clin Pract. 2021 Aug 13;179:109002. doi: 10.1016/j.diabres.2021.109002. Epub ahead of print. PMID: 34391829.
Laber S, Forcisi S, Bentley L, et al. Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo. Sci Adv. 2021;7(30):eabg0108. Published 2021 Jul 21. doi:10.1126/sciadv.abg0108. PMC: 8294759. PMID: 34290091
Giessen H, Kerschbaum E, Hauner D, Hauner H. Nutrition and Cancer Prevention: What do we know today?. (68) 2021, 10.4455/eu.2021.012
Kellerer T, Kleigrewe K, Brandl B, Hofmann T, Hauner H, Skurk T: Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Are Associated With Diet, BMI, and Age. Frontiers in Nutrition. 2021 Jul 12. 21 (8).p. 436. Doi:10.3389/fnut.2021.691401
Hauner, H. Evidenz in der Ernährungstherapie des Diabetes mellitus. Diabetologe (2021). doi.org/10.1007/s11428-021-00784-2
Honecker J, Weidlich D, Heisz S, Lindgren CM, Karampinos DC, Claussnitzer M, Hauner H. A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function. Int J Obes (Lond). 2021 Jun 25. doi: 10.1038/s41366-021-00883-6. Epub ahead of print. PMID: 34172828.
Bayer S, Holzapfel C_Personalisierte Ernährung, genbasierte Ernährungsempfehlungen zur Gewichtsreduktion. Ernährung & Medizin.2021.36.p.53-59
Syväri J, Junker D, Patzelt L, Kappo K, Al Sadat L, Erfanian S, Makowski MR, Hauner H, Karampinos DC. Longitudinal changes on liver proton density fat fraction differ between liver segments. Quant Imaging Med Surg. 2021 May;11(5):1701-1709. doi: 10.21037/qims-20-873. PMID: 33936958; PMCID: PMC8047351.
Eisele Y, Mallea PM, Gigic B, Stephens WZ, Warby CA, Buhrke K, Lin T, Boehm J, Schrotz-King P, Hardikar S, Huang LC, Pickron TB, Scaife CL, Viskochil R, Koelsch T, Peoples AR, Pletneva MA, Bronner M, Schneider M, Ulrich AB, Swanson EA, Toriola AT, Shibata D, Li CI, Siegel EM, Figueiredo J, Janssen KP, Hauner H, Round J, Ulrich CM, Holowatyj AN, Ose J. Fusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study. Clin Colorectal Cancer. 2021 Feb 27:S1533-0028(21)00021-9. doi: 10.1016/j.clcc.2021.02.007. Epub ahead of print. PMID: 33935016.
Greetfeld M, Hessler-Kaufmann JB, Brandl B, Skurk T, Holzapfel C et al. Orthorexic tendencies in the general population: association with demographic data, psychiatric symptoms, and utilization of mental health services. Eating and Weight Disorders; Heidelberg Bd. 26, Ausg. 5, (Jun 2021): 1511-1519. DOI:10.1007/s40519-020-00961-0
Kellerer T, Brandl B, Büttner J, Lagkouvardos I, Hauner H, Skurk T. Correction to: Impact of Laparoscopic Sleeve Gastrectomy on Gut Permeability in Morbidly Obese Subjects. Obes Surg. 2021 Apr 29. doi: 10.1007/s11695-021-05439-1. Epub ahead of print. Erratum for: Obes Surg. 2019 Jul;29(7):2132-2143. PMID: 33928525.
Hessler-Kaufmann JB, Meule A, Holzapfel C, Brandl B, Greetfeld M, Skurk T, Schlegl S, Hauner H, Voderholzer U. Orthorexic tendencies moderate the relationship between semi-vegetarianism and depressive symptoms. Eat Weight Disord. 2021 Mar;26(2):623-628. doi: 10.1007/s40519-020-00901-y. Epub 2020 Apr 21
Strüven A, Holzapfel C, Stremmel C, Brunner S. Obesity, Nutrition and Heart Rate Variability. Int J Mol Sci. 2021;22(8):4215. Published 2021 Apr 19. doi:10.3390/ijms22084215
Geyer K, Spies M, Günther J, Hoffmann J, Raab R, Meyer D, Rauh K, Hauner H. Effects of a Prenatal Lifestyle Intervention in Routine Care on Maternal Health Behaviour in the First Year Postpartum-Secondary Findings of the Cluster-Randomised GeliS Trial. Nutrients. 2021 Apr 15;13(4):1310. doi: 10.3390/nu13041310. PMID: 33921063; PMCID: PMC8071441.
Miehle E, Bader-Mittermaier S, Schweiggert-Weisz U, Hauner H, Eisner P. Effect of Physicochemical Properties of Carboxymethyl Cellulose on Diffusion of Glucose. Nutrients. 2021 Apr 21;13(5):1398. doi: 10.3390/nu13051398. PMID: 33919341.
Günther J, Hoffmann J, Stecher L, Spies M, Geyer K, Raab R, Meyer D, Rauh K, Hauner H. How does antenatal lifestyle affect the risk for gestational diabetes mellitus? A secondary cohort analysis from the GeliS trial. Eur J Clin Nutr. 2021 Apr 23. doi: 10.1038/s41430-021-00910-9. Epub ahead of print. PMID: 33893447.
Holzapfel C, Sag S, Graf-Schindler J, Fischer M, Drabsch T, Illig T, Grallert H, Stecher L, Strack C, Caterson ID, Jebb SA, Hauner H, Baessler A. Association between Single Nucleotide Polymorphisms and Weight Reduction in Behavioural Interventions-A Pooled Analysis. Nutrients. 2021 Mar 2;13(3):819. doi:
10.3390/nu13030819. PMID: 33801339; PMCID: PMC7998423.
Weidlich D, Honecker J, Boehm C, Ruschke S, Junker D, Van AT, Makowski MR, Holzapfel C, Claussnitzer M, Hauner H, Karampinos DC. Lipid droplet-size mapping in human adipose tissue using a clinical 3T system. Magn Reson Med. 2021 Apr 1. doi: 10.1002/mrm.28755. Epub ahead of print. PMID: 33797107.
Morris E, Jebb SA, Oke J, Nickless A, Ahern A, Boyland E, Caterson ID, Halford J, Hauner H, Aveyard P. Effect of weight loss on cardiometabolic risk: observational analysis of two randomised controlled trials of community weight-loss programmes. Br J Gen Pract. 2021 Mar 26;71(705):e312-e319. doi:
10.3399/bjgp20X714113. PMID: 33685923; PMCID: PMC7959667.
Holzapfel C. Veganer erleiden viel häufiger Knochenbrüche. MMW Fortschr Med. 2021 Mar;163(5):31. German. doi: 10.1007/s15006-021-9729-6. PMID: 33710554.
Sedlmeier EM, Meyer DM, Stecher L, Sailer M, Daniel H, Hauner H, Bader BL. Fetal sex modulates placental microRNA expression, potential microRNA-mRNA interactions, and levels of amino acid transporter expression and substrates: INFAT study subpopulation analysis of n-3 LCPUFA intervention during pregnancy and associations with offspring body composition. BMC Mol Cell Biol. 2021 Mar 3;22(1):15. doi: 10.1186/s12860-021-00345-x. PMID: 33657992; PMCID: PMC7931339.
Rennekamp R, Brandl B, Giesbertz P, Skurk T, Hauner H. Metabolic and satiating effects and consumer acceptance of a fibre-enriched Leberkas meal: a randomized cross-over trial. Eur J Nutr. 2021 Feb 8. doi: 10.1007/s00394-020-02472-1. Epub ahead of print. PMID: 33555374.
Sinnott-Armstrong N, Sousa IS, Laber S, Rendina-Ruedy E, Nitter Dankel SE, Ferreira T, Mellgren G, Karasik D, Rivas M, Pritchard J, Guntur AR, Cox RD, Lindgren CM, Hauner H, Sallari R, Rosen CJ, Hsu YH, Lander ES, Kiel DP, Claussnitzer M. A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. Cell Metab. 2021 Jan 25:S1550-4131(21)00001-2. doi: 10.1016/j.cmet.2021.01.001. Epub ahead of print. PMID: 33513366.
Koletzko B, Holzapfel C, Schneider U, Hauner H. Lifestyle and Body Weight Consequences of the COVID-19 Pandemic in Children: Increasing Disparity. Ann Nutr Metab. 2021 Jan 26:1-3. doi: 10.1159/000514186. Epub ahead of print. PMID: 33498055.
Raab R, Michel S, Günther J, Hoffmann J, Stecher L, Hauner H. Associations between lifestyle interventions during pregnancy and childhood weight and growth: a systematic review and meta-analysis. Int J Behav Nutr Phys Act. 2021 Jan 7;18(1):8. doi: 10.1186/s12966-020-01075-7. PMID: 33413486; PMCID: PMC7792105.
Hauner H, Nitschmann S. Life expectancy after bariatric surgery: Swedish Obese Subjects Study. Internist (Berl). 2021 Jan 26. doi: 10.1007/s00108-021-00947-9. Online ahead of print.
Kongressbeiträge und sonstige Veröffentlichungen | KEM | 2021
Bayer S, Reik A, von Hesler L, Hauner H, Holzapfel C. Zusammenhang zwischen Genotypen und der glykämischen Antwort nach einem oralen Glukosetoleranztest: eine systematische Übersichtsarbeit. Adipositas - Ursachen, Folgeerkrankungen, Therapie. 2021; 15(03): 164
DOI: 10.1055/s-0041-1735706
Günther J, Hoffmann J, Stecher L, Spies M, Geyer K, Raab R, Meyer D, Rauh K, Hauner H. Wie beeinflusst der pränatale Lebensstil das Risiko für Gestationsdiabetes? Eine Kohortenanalyse der bayernweiten „Gesund leben in der Schwangerschaft“ (GeliS) Studie.Diabetologie und Stoffwechsel 2021; 16(S 01): S42. DOI: 10.1055/s-0041-1727401
Holzapfel C, Wiechert M, Jocher M, Mittermaier S, Hauner H. Portion Size and Energy Content of Lunch Meals when consumed outside the Home An exploratory Survey based on selected Dishes. (68) 2021, DOI: 10.4455/eu.2021.015
Holzapfel C, Dawczynski C, Henze A, Simon MC: Personalized dietary recommendations for weight loss. A scientific perspective from various angles. Ernahrungs Umschau 2021; 68(2): 26–35. DOI: 10.4455/eu.2021.008
Holzapfel C. Abspecken mit der App - läuft gut! MMW Fortschr Med. 2021; 163(2): 28-29. doi: 10.1007/s15006-021-9590-7 ppublish. PMID:33527281
2020
Hauner D, Rack B, Friedl T, Hepp P., Janni W, Hauner H. Rationale and description of a lifestyle intervention programme to achieve moderate weight loss in women with non-metastatic breast cancer: the lifestyle intervention part of the SUCCESS C Study. BMJ Nutrition, Prevention & Health Dec 2020, 3 (2) 213-219; DOI: 10.1136/bmjnph-2020-000119
Reik A, Holzapfel C. Randomized Controlled Lifestyle Intervention (LION) Study for Weight Loss and Maintenance in Adults With Obesity-Design and Methods. Front Nutr 2020; Nov 10;7:586985. doi: 10.3389/fnut.2020.586985 PMID: 33240920
Bayer S, Drabsch T, Schauberger G, Hauner H, Holzapfel C. Knowledge, opinions, and expectations of adults concerning personalised genotype-based dietary recommendations: a German survey. Public Health Nutr. 2020; Oct 19;1-11. doi: 10.1017/S1368980020004152. Online ahead of print. PMID: 33070793
Holzmann SL, Schaefer H, Groh G, Plecher DA, Klinker G, Schauberger G, Hauner H, Holzapfel C. Effects of the Digital Game "Fit, Food, Fun" on Nutritional Knowledge: A Pilot Study among German Children and Adolescents. Proc Nutr Soc 2020; 79(OCE2): E525-E525
Meyer DM, Stecher L, Brei C, Hauner H. Mid-pregnancy weight gain is associated with offspring adiposity outcomes in early childhood. Pediatr Res 2020; Oct 17. doi: 10.1038/s41390-020-01202-x. Online ahead of print PMID: 33069163
Meyer DM, Brei C, Bader BL, Hauner H. Evaluation of Maternal Dietary n-3 LCPUFA Supplementation as a Primary Strategy to Reduce Offspring Obesity: Lessons From the INFAT Trial and Implications for Future Research. Front Nutr 2020; Sep 15;7:156. doi: 10.3389/fnut.2020.00156 PMID: 33043038
Brandl B, Skurk T, Rennekamp R, Hannink A, Kiesswetter E, Freiherr J, Ihsen S, Roosen J, Klingenspor M, Haller D, Krautwurst D, Hofmann T, Linseisen J, Volkert D, Hauner H. A Pheno-typing Platform to Characterize Healthy Individuals Across Four Stages of Life - The Enable Study. Front Nutr 2020; Oct 28;7:582387. doi: 10.3389/fnut.2020.582387 PMID: 33195372
Riedl A, Wawro N, Gieger C, Meisinger C, Peters A, Rathmann W, Koenig W, Strauch K, Quante AS, Thorand B, Huth C, Daniel H, Hauner H, Linseisen J. Modifying effect of metabotype on diet-diabetes associations. Eur J Nutr 2020; 59(4): 1357-1369 PMID: 31089867
Wang L, Sinnott-Armstrong N, Wagschal A, Wark AR, Camporez JP, Perry RJ, Ji F, Sohn Y, Oh J, Wu S, Chery J, Moud BN, Saadat A, Dankel SN, Mellgren G, Tallapragada DSP, Strobel SM, Lee MJ, Tewhey R, Sabeti PC, Schaefer A, Petri A, Kauppinen S, Chung RT, Soukas A, Avruch J, Fried SK, Hauner H, Sadreyev RI, Shulman GI, Claussnitzer M, Näär AMA: MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell 2020; 183(3): 684-701.e14; PMID: 33058756
Hauner D, Rack B, Friedl T, Hepp P, Janni W, Hauner H. Rationale and description of a lifestyle intervention programme to achieve moderate weight loss in women with non-metastatic breast cancer: the lifestyle intervention part of the SUCCESS C Study. BMJ Nutrition, Prevention & Health 2020. doi: 10.1136/bmjnph-2020-000119 BMJ
Ludolph K, Hauner D, Nüssler V, Wendtner CM, Hauner H.Barrieren für Ernährungstherapie in der stationären Hämatologie/Onkologie. Ernährungsumschau. 2020 (9). M536-M544. Ernährungsumschau
Bayer S, Winkler V, Hauner H, Holzapfel, C. Associations between Genotype–Diet Interactions and Weight Loss—A Systematic Review. Nutrients 2020, 12, 2891. mdpi
Glastonbury CA, Pulit S L, Honecker J, Censin JC, Laber S, Yaghootkar H, Rahmioglu N, Pastel E, Kos K, Pitt A, Hudson M, Nellåker C, Beer NL, Hauner H, Becker CM, Zondervan KT, Frayling TM, Claussnitzer M, Lindgren CM. Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits. PLoS Comput Biol. 2020;16(8):e1008044. Published 2020 Aug 14. doi:10.1371/journal.pcbi.1008044. pubmed
Mank M, Hauner H, Heck AJR, Stahl B. Targeted LC-ESI-MS2 characterization of human milk oligosaccharide diversity at 6 to 16 weeks post-partum reveals clear staging effects and distinctive milk groups [published online ahead of print, 2020 Aug 14]. Anal Bioanal Chem. 2020;10.1007/s00216-020-02819-x. doi:10.1007/s00216-020-02819-x. pubmed
von Philipsborn P, Stratil JM, Burns J, Busert LK, Pfadenhauer LM, Polus S, Holzapfel C, Hauner H, Rehfuess EA. Environmental Interventions to Reduce the Consumption of Sugar-Sweetened Beverages: Abridged Cochrane Systematic Review [published online ahead of print, 2020 Aug 12]. Obes Facts. 2020;1-21. doi:10.1159/000508843. pubmed
Syväri J, Ruschke S, Dieckmeyer M, Hauner H, Junker D, Makowski MR, Baum T, Karampinos DC. Estimating vertebral bone marrow fat unsaturation based on short-TE STEAM MRS [published online ahead of print, 2020 Aug 11]. Magn Reson Med. 2020;10.1002/mrm.28453. doi:10.1002/mrm.28453. pubmed
Greetfeld M, Hessler-Kaufmann JB, Brandl B, Skurk T, Holzapfel C, Quadflieg N, Schlegl S, Hauner H und Voderholzer U. Orthorexic tendencies in the general population: association with demographic data, psychiatric symptoms, and utilization of mental health services. Eat Weight Disord (2020). doi.org/10.1007/s40519-020-00961-0. pubmed
Hoffmann J, Günther J, Stecher L, Spies M, Geyer K, Raab R, Meyer D, Rauh K und Hauner H. Infant growth during the first year of life following a pregnancy lifestyle intervention in routine care—Findings from the cluster‐randomised GeliS trial. Pediatric obesity. e12705. First published: 28 July 2020. Wiley Online Library
Bayer S, Drabsch T, Schauberger G, Hauner H, Holzapfel C. Responsibility of Individuals and Stakeholders for Obesity and a Healthy Diet: Results From a German Survey. Front Psychiatry. 2020;11:616. Published 2020 Jul 3. doi:10.3389/fpsyt.2020.00616. pubmed
Holzmann SL, Schäfer H, Groh G, et al. Short-Term Effects of the Serious Game "Fit, Food, Fun" on Nutritional Knowledge: A Pilot Study among Children and Adolescents. Nutrients. 2019;11(9):2031. Published 2019 Aug 30. doi:10.3390/nu11092031. pubmed
Johar H, Hoffmann J, Günther J, Atasoy S, Stecher L, Spies M, Hauner H, Ladwig K-H. Evaluation of antenatal risk factors for postpartum depression: a secondary cohort analysis of the cluster-randomised GeliS trial. BMC Med. 2020;18(1):227. Published 2020 Jul 24. doi:10.1186/s12916-020-01679-7. pubmed
Reitmeier S, Kiessling S, Clavel T, List M, Almeida EL, Ghosh TS, Neuhaus K, Grallert H, Linseisen J, Skurk T, Brandl B, Breuninger TA, Troll M, Rathmann W, Linkohr B, Hauner H, Laudes M, Franke A, Le Roy CI, Bell JT, Spector T, Baumbach J, O'Toole PW, Peters A, Haller D. Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes.Cell Host Microbe. 2020 Jun 29. pii: S1931-3128(20)30343-7. doi: 10.1016/j.chom.2020.06.004. pubmed
Burian, E., Syväri, J., Dieckmeyer, M. et al. Age- and BMI-related variations of fat distribution in sacral and lumbar bone marrow and their association with local muscle fat content. Sci Rep 10, 9686 (2020). doi.org/10.1038/s41598-020-66649-8. pubmed
Holzapfel C, Kocsis A, Jaeckel B, Martignoni M, Hauner D, Hauner H. Dietary Forms and Intake of Nutritional Supplements in Patients with Tumor Diseases A survey in Oncology Practices. Ernahr Umsch 2020; 67(3): M148-M156
Junker D, Syväri J, Weidlich D, et al. Investigation of the Relationship between MR-Based Supraclavicular Fat Fraction and Thyroid Hormones [published online ahead of print, 2020 Jun 19]. Obes Facts. 2020;1-13. doi:10.1159/000507294. pubmed
Holzmann SL, Schäfer H, Plecher DA, Stecher L, Klinker GJ, Groh G, Hauner H, Holzapfel C.Serious Games for Nutritional Education: Online Survey on Preferences, Motives, and Behaviors Among Young Adults at University. JMIR Serious Games 2020;8(2):e16216. DOI: 10.2196/16216. pubmed
Bauer K, Lau T, Schwille-Kiuntke J, Schild S, Hauner H, Stengel A, Zipfel S, Mack I.Conventional weight loss interventions across the different BMI obesity classes: A systematic review and quantitative comparative analysis. Eur Eat Disord Rev. 2020 May 3. doi: 10.1002/erv.2741. [Epub ahead of print]. pubmed
Mengel LA, Seidl H, Brandl B, Skurk T, Holzapfel C, Stecher L, Claussnitzer M, Hauner H. Gender Differences in the Response to Short-term Cold Exposure in Young Adults. J Clin Endocrinol Metab. 2020 May 1;105(5):dgaa110. doi: 10.1210/clinem/dgaa110
Hessler-Kaufmann, J.B., Meule, A., Holzapfel, C., Beate Brandl, A., Greetfeld, M., Skurk, T., Schlegl, S., Hauner, H., Voderholzer, U.: Orthorexic tendencies moderate the relationship between semi-vegetarianism and depressive symptoms. Eat Weight Disord (2020). pubmed
Paslakis, G., Richardson, C., Nöhre, M., Brähler, E., Holzapfel, C., Hilbert, A., de Zwaan, M.: Prevalence and psychopathology of vegetarians and vegans – Results from a representative survey in Germany. Sci Rep 10, 6840 (2020). pubmed
Holzapfel C, Hauner H. Vegan woman wishes to have children. MMW Fortschr Med. 2020 Mar;162(5):47-49. doi: 10.1007/s15006-020-0263-8. pubmed
Riedl A, Hillesheim E, Wawro N, Meisinger C, Peters A, Roden M, Kronenberg F, Herder C, Rathmann W, Völzke H, Reincke M, Koenig W, Wallaschofski H, Daniel H, Hauner H, Brennan L, Linseisen J.
Evaluation of the Metabotype Concept Identified in an Irish Population in the German KORA Cohort Study. Mol Nutr Food Res. 2020 Apr;64(8):e1900918. doi: 10.1002/mnfr.201900918. Epub 2020 Feb 20.
Brandl B, Lee YM, Dunkel A, Hofmann T, Hauner H, Skurk T:Effects of Extrinsic Wheat Fiber Supplementation on Fecal Weight; A Randomized Controlled Trial. Nutrients. 2020 Jan 22;12(2). pii: E298. doi: 10.3390/nu12020298. MDPI
Alligier M, Barrès R, Blaak EE, Boirie Y, Bouwman J, Brunault P, Campbell K, Clément K, Farooqi IS, Farpour-Lambert NJ, Frühbeck G, Goossens GH, Hager J, Halford JCG, Hauner H, Jacobi D, Julia C, Langin D, Natali A, Neovius M, Oppert JM, Pagotto U, Palmeira AL, Roche H, Rydén M, Scheen AJ, Simon C, Sorensen TIA, Tappy L, Yki-Järvinen H, Ziegler O, Laville M: OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions.Obes Facts. 2020 Jan 16:1-28. doi: 10.1159/000505342. pubmed
Kunzke T, Buck A, Prade VM, Feuchtinger A, Prokopchuk O, Martignoni ME, Heisz S, Hauner H, Janssen KP, Walch A, Aichler M. Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction. J Cachexia Sarcopenia Muscle 2020; 11(1): 226-240. pubmed
Matejka K, Stückler F, Salomon M, Ensenauer R, Reischl E, Hoerburger L, Grallert H, Kastenmüller G, Peters A, Daniel H, Krumsiek J, Theis FJ, Hauner H, Laumen H: Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants. PLoS One. 2019 May 23;14(5):e0216110. doi: 10.1371/journal.pone.0216110. eCollection 2019. pubmed
Meule A, Holzapfel C, Brandl B, Greetfeld M, Hessler-Kaufmann JB, Skurk T, Quadflieg N, Schlegl S, Hauner H, Voderholzer U. Measuring orthorexia nervosa: A comparison of four self-report questionnaires. Appetite.2020 Mar. 1; 146:104512. doi: 10.1016/j.appet.2019.104512. sciencedirect
Hauner H, Kocsis A, Jaeckel B, Martignoni M, Hauner H, Holzapfel C. Prevalence of malnutrition risk in patients of cancer outpatient clinics - a cross-sectional survey. Dtsch Med Wochenschr. 2020 Jan;145(1):e1-e9. doi: 10.1055/a-1008-5702. Epub 2019 Dec 13. pubmed
Giesbertz P, Brandl B, Lee Y-L, Hauner H, Daniel H, Skurk T. Specificity, Dose Dependency, and Kinetics of Markers of Chicken and Beef Intake Using Targeted Quantitative LC‐MS/MS: a Human Intervention Trial. Mol Nutr Food Res. 2020;64(5):e1900921. doi:10.1002/mnfr.201900921. Wiley online library
Kongressbeiträge und sonstige Veröffentlichungen | KEM | 2020
Holzmann SL, Schaefer H, Groh G, Plecher DA, Klinker G, Schauberger G, Hauner H, Holzapfel C.Effects of the Digital Game "Fit, Food, Fun" on Nutritional Knowledge: A Pilot Study among German Children and Adolescents. Proc Nutr Soc 2020; 79(OCE2): E525-E525 (Meeting Abstract)
Riedl A, Wawro N, Meisinger C, Peters A, Rathmann W, Koenig W, Daniel H, Hauner H, Brennan L, Linseisen J. Validation of metabotypes identified in an Irish population in the German KORA FF4 study. Proc Nutr Soc 2020; 79(OCE2): E380-E380 (Meeting Abstract)
Holzapfel C, Kocsis A, Jaeckel B, Martignoni M, Hauner D, Hauner H (2020) Dietary habits and intake of nutritional supplements in patients of outpatient cancer clinics. Ernahrungs Umschau 67(3): 60–8. DOI: 10.4455/eu.2020.009 Ernährungs Umschau
Holzapfel C, Hauner H. Veganerin will schwanger werden. MMW Fortschr Med. 2020 Mar;162(5):47-49. doi: 10.1007/s15006-020-0263-8.
Holzapfel C, Hauner H. Veganerin will schwanger werden. MMW Fortschr Med. 2020 Mar;162(5):47-49. doi: 10.1007/s15006-020-0263-8. PMID: 32189260
Rubin D, Bosy-Westphal A, Kabisch S, Kronsbein P, Simon MC, Tombek A, Weber K, Skurk T, Ausschuss Ernaehrung DDG. Diet Recommendations for People with Type-1-Diabetes mellitus. Diabetol Stoffwechs 2020; 15 Suppl 01(): S120-S138;
Holzapfel C. So hält der Abspeck-Erfolg länger an: Ernährungsmedizin. MMW Fortschr Med 2020; May;162(10):29. doi: 10.1007/s15006-020-0511-y PMID: 32447689
Holzapfel C. Weder kohlenhydrat- noch fettarme Kost verlängern per se das Leben: Ernährungsmedizin. MMW Fortschr Med 2020; Apr;162(8):28-29. doi: 10.1007/s15006-020-0418-7. PMID: 32342382
Hauner H. The COVID-19 Pandemic: A Challenge for Obesity Research and Management. Obes Facts. 2020 Sep 22:1-2. doi: 10.1159/000511186. Online ahead of print. PMID: 32961534
Holzapfel C. Ernährungsmuster relevanter als einzelne Nährstoffe: Kardiovaskuläre Gesundheit. MMW Fortschr Med. 2020 Aug;162(14):24-25. doi: 10.1007/s15006-020-0733-z.
Kaiser B, Holzmann SL, Hauner H, Holzapfel C, Gedrich K. Stress Übersicht ausgewählter Stress-indikatoren und smarter Messtechniken. Ernährungsumschau 2020; 67 (5): 98-107. doi: 10.4455/eu.2020.017
Schmidt-Tesch S, Hauner H. Herzschutz aus der Kapsel? HERZ heute 2020; 2:12-19
Schmidt-Tesch S, Hauner H. Strategien gegen Übergewicht. In „Das Schwache Herz“, Deutsche Herzstiftung 2020, S126-133
2019
Hauner H, Kocsis A, Jaeckel B, Martignoni M, Hauner H, Holzapfel C. Häufigkeit eines Risikos für Mangelernährung bei Patienten in onkologischen Schwerpunktpraxen – eine Querschnittserhebung Dtsch med Wochenschr. online publiziert: 13.12.2019. DOI: 10.1055/a-1008-5702
Kunzke T, Buck A, Prade VM, Feuchtinger A, Prokopchuk O, Martignoni ME, Heisz S, Hauner H, Janssen K-P, Walch A, Aichler M. Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction. Journal of Cachexia, Sarcopenia and Muscle 2019. 13 November 2019. doi.org/10.1002/jcsm.12498. wiley online library
Hoffmann J, Günther J, Geyer K, Stecher L, Rauh K, Kunath J, Meyer D, Sitzberger C, Spies M, Rosenfeld E, Kick L, Oberhoffer R, Hauner H. Effects of a lifestyle intervention in routine care on prenatal physical activity - findings from the cluster-randomised GeliS trial. BMC Pregnancy Childbirth. 2019 Nov 11;19(1):414. doi: 10.1186/s12884-019-2553-7. pubmed
Meule A, Holzapfel C, Brandl B, Greetfeld M, Hessler-Kaufmann JB, Skurk T, Quadflieg N, Schlegl S, Hauner H, Voderholzer U. Measuring orthorexia nervosa: A comparison of four self-report questionnaires. Appetite. 2019 Nov 7:104512. doi: 10.1016/j.appet.2019.104512. sciencedirect
Dankel SN, Røst TH, Kulyté A, Fandalyuk Z, Skurk T, Hauner H, Sagen JV, Rydén M, Arner P, Mellgren G. The Rho GTPase RND3 regulates adipocyte lipolysis. Metabolism. 2019 Oct 28:153999. doi: 10.1016/j.metabol.2019.153999. pubmed
Hoffmann J, Günther J, Geyer K, Stecher L, Kunath J, Meyer D, Spies M, Rosenfeld E, Kick L, Rauh K, Hauner H. Associations between Prenatal Physical Activity and Neonatal and Obstetric Outcomes-A Secondary Analysis of the Cluster-Randomized GeliS Trial. J Clin Med 2019 Oct 19;8(10). mdpi
Gingrich A, Spiegel A, Gradl JE, Skurk T, Hauner H, Sieber CC, Volkert D, Kiesswetter E. Daily and per-meal animal and plant protein intake in relation to muscle mass in healthy older adults without functional limitations: an enable study. Aging Clin Exp Res. 2019 Sep;31(9):1271-1281. doi: 10.1007/s40520-018-1081-z. Epub 2018 Dec 5. pubmed
Rogozińska E, Zamora J, Marlin N, Betrán AP, Astrup A, Bogaerts A, Cecatti JG, Dodd JM, Facchinetti F, Geiker NRW, Haakstad LAH, Hauner H, Jensen DM, Kinnunen TI, Mol BWJ, Owens J, Phelan S, Renault KM, Salvesen KÅ, Shub A, Surita FG, Stafne SN, Teede H, van Poppel MNM, Vinter CA, Khan KS, Thangaratinam S; International Weight Management in Pregnancy (i-WIP) Collaborative Group. Gestational weight gain outside the Institute of Medicine recommendations and adverse pregnancy outcomes: analysis using individual participant data from randomised trials. BMC Pregnancy Childbirth. 2019 Sep 2;19(1):322. doi: 10.1186/s12884-019-2472-7. pubmed
Holzapfel C. Lebensmittelkennzeichnung als Maßnahme zur Prävention von Übergewicht und Adipositas. 2019 Adipositas 13:127-132
Hauner, H, Moss, A, Berg, A et al. Adipositas und Diabetes mellitus. Diabetologe (2019) 15(6): 573-579. doi.org/10.1007/s11428-019-00534-5
Holzmann SL, Schäfer H, Groh G,Plecher DA, Klinker G, Schauberger G, Hauner H, Holzapfel C. Short-Term Effects of the Serious Game “Fit, Food, Fun” on Nutritional Knowledge: A Pilot Study among Children and Adolescents. Nutrients 2019, 11(9), 2031; https://doi.org/10.3390/nu11092031. pubmed
Günther J, Hoffmann J, Spies M, Meyer D, Kunath J, Stecher L, Rosenfeld E, Kick L, Rauh K, Hauner H. Associations between the Prenatal Diet and Neonatal Outcomes-A Secondary Analysis of the Cluster-Randomised GeliS Trial. Nutrients. 2019 Aug 13;11(8). pii: E1889. doi: 10.3390/nu11081889. pubmed
Becker M, Serr I, Salb VK, Ott VB, Mengel L, Blüher M, Weigmann B, Hauner H, Tschöp MH, Daniel C.Short-term cold exposure supports human Treg induction in vivo. Mol Metab. 2019 Aug 5. pii: S2212-8778(19)30554-X. pubmed
O'Brien EC, Segurado R, Geraghty AA, Alberdi G, Rogozinska E, Astrup A, Barakat Carballo R, Bogaerts A, Cecatti JG, Coomarasamy A, de Groot CJM, Devlieger R, Dodd JM, El Beltagy N, Facchinetti F, Geiker N, Guelfi K, Haakstad L, Harrison C, Hauner H, Jensen DM, Khan K, Kinnunen TI, Luoto R, Willem Mol B, Mørkved S, Motahari-Tabari N, Owens JA, Perales M, Petrella E, Phelan S, Poston L, Rauh K, Rayanagoudar G, Renault KM, Ruifrok AE, Sagedal L, Salvesen KÅ, Scudeller TT, Shen G, Shub A, Stafne SN, Surita FG, Thangaratinam S, Tonstad S, van Poppel MNM, Vinter C, Vistad I, Yeo S, McAuliffe FM; i-WIP (International Weight Management in Pregnancy) Collaborative Group.Impact of maternal education on response to lifestyle interventions to reduce gestational weight gain: individual participant data meta-analysis. BMJ Open. 2019 Aug 1;9(8):e025620. pubmed
Günther J , Hoffmann J , Kunath J , Spies M , Meyer D , Stecher L , Rosenfeld E , Kick L , Rauh K , Hauner H. Effects of a Lifestyle Intervention in Routine Care on Prenatal Dietary Behavior-Findings from the Cluster-Randomized GeliS Trial. J Clin Med 2019 Jul 2;8(7)
Michel S, Raab R, Drabsch T, Günther J, Stecher L, Hauner H. Do lifestyle interventions during pregnancy have the potential to reduce long-term postpartum weight retention? A systematic review and meta-analysis. Obes Rev 2019; 20(4): 527-542. pubmed
Ulaszewska MM, Weinert CH, Trimigno A, Portmann R, Andres Lacueva C, Badertscher R, Brennan L, Brunius C, Bub A, Capozzi F, Cialiè Rosso M, Cordero CE, Daniel H, Durand S, Egert B, Ferrario PG, Feskens EJM, Franceschi P, Garcia-Aloy M, Giacomoni F, Giesbertz P, González-Domínguez R, Hanhineva K, Hemeryck LY, Kopka J, Kulling SE, Llorach R, Manach C, Mattivi F, Migné C, Münger LH, Ott B, Picone G, Pimentel G, Pujos-Guillot E, Riccadonna S, Rist MJ, Rombouts C, Rubert J, Skurk T, Sri Harsha PSC, Van Meulebroek L, Vanhaecke L, Vázquez-Fresno R, Wishart D, Vergeres G. Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies. Mol Nutr Food Res 2019; 63(1): e1800384. pubmed
Rohm F, Skurk T, Daniel H, Spanier B. Appearance of Di- and Tripeptides in Human Plasma after a Protein Meal Does Not Correlate with PEPT1 Substrate Selectivity.
Mol Nutr Food Res 2019; 63(5): e1801094. pubmed
Striegel L, Brandl B, Kopp M, Sam L, Skurk T, Rychlik M. Quantitation of 5-methyltetraydrofolic acid in plasma for determination of folate status and clinical studies by stable isotope dilution assays. PLoS ONE 2019; 14(2): e0212255 pubmed
von Philipsborn P, Stratil JM, Burns J, Busert LK, Pfadenhauer LM, Polus S, Holzapfel C, Hauner H, Rehfuess E. Environmental interventions to reduce the consumption of sugar‐sweetened beverages and their effects on health. Cochrane Database of Systematic Reviews 2019, Issue 6. Art. No.: CD012292. Cochrane Library
Quell JD, Römisch-Margl W, Haid M, Krumsiek J, Skurk T, Halama A, Stephan N, Adamski J, Hauner H, Mook-Kanamori D, Mohney RP, Daniel H, Suhre K, Kastenmüller G.
Characterization of Bulk Phosphatidylcholine Compositions in Human Plasma Using Side-Chain Resolving Lipidomics.Metabolites. 2019 Jun 8;9(6) pubmed
Hoffmann J, Günther J, Stecher L, Spies M, Meyer D, Kunath J, Raab R, Rauh K, Hauner H.
Effects of a Lifestyle Intervention in Routine Care on Short- and Long-Term Maternal Weight Retention and Breastfeeding Behavior—12 Months Follow-up of the Cluster-Randomized GeliS Trial. J. Clin. Med. 19 June 2019, 8(6), 876. doi:10.3390/jcm8060876 lesen
Matejka K, Stückler F, Salomon M, Ensenauer R, Reischl E, Hoerburger L, Grallert H, Kastenmüller G, Peters A, Daniel H, Krumsiek J, Theis FJ, Hauner H, Laumen H.
Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants.PLoS One. 2019 May 23;14(5):e0216110. doi: 10.1371/journal.pone.0216110. eCollection 2019. pubmed
Riedl A, Wawro N, Gieger C, Meisinger C, Peters A, Rathmann W, Koenig W, Strauch K, Quante AS, Thorand B, Huth C, Daniel H, Hauner H, Linseisen J.
Modifying effect of metabotype on diet-diabetes associations.Eur J Nutr. 2019 May 14 pubmed
Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T. Adipose Mitochondrial Respiratory Capacity in Obesity is Impaired Independently of Glycemic Status of Tissue Donors. Obesity (Silver Spring). 2019 Mar 26. doi: 10.1002/oby.22435. [Epub ahead of print]. pubmed
Kellerer T, Brandl B, Büttner J, Lagkouvardos I, Hauner H, Skurk T. Impact of Laparoscopic Sleeve Gastrectomy on Gut Permeability in Morbidly Obese Subjects. Obes Surg. 2019 Mar 22. doi: 10.1007/s11695-019-03815-6. [Epub ahead of print]. pubmed
Drabsch T, Holzapfel C. A Scientific Perspective of Personalised Gene-Based Dietary Recommendations for Weight Management. Nutrients 2019 11(3), 617; lesen
Rempe HM, Sproesser G, Gingrich A, Spiegel A, Skurk T, Brandl B, Hauner H, Renner B, Volkert D, Sieber CC, Freiberger E, Kiesswetter E. Measuring eating motives in older adults with and without functional impairments with The Eating Motivation Survey (TEMS). Appetite. 2019 Feb 15. pii: S0195-6663(18)31452-1. doi: 10.1016/j.appet.2019.01.024. pubmed
Holzmann SL, Dischl F, Schäfer H, Groh G, Hauner H, Holzapfel C. Digital Gaming for Nutritional Education: A Survey on Preferences, Motives and Needs of Children and Adolescents. JMIR Form Res 2019;3(1):e10284. doi:10.2196/10284 lesen
Franz D, Diefenbach MN, Treibel F, Weidlich D, Syväri J, Ruschke S, Wu M, Holzapfel C, Drabsch T, Baum T, Eggers H, Rummeny EJ, Hauner H, Karampinos DC. Differentiating supraclavicular from gluteal adipose tissue based on simultaneous PDFF and T<sub>2</sub> * mapping using a 20-echo gradient-echo acquisition. J Magn Reson Imaging. 2019 Jan 25. doi: 10.1002/jmri.26661. pubmed
Weidlich D, Honecker J, Gmach O, Wu M, Burgkart R, Ruschke S, Franz D, Menze BH, Skurk T, Hauner H, Kulozik U, Karampinos DC. Measuring large lipid droplet sizes by probing restricted lipid diffusion effects with diffusion-weighted MRS at 3T. Magn Reson Med. 2019 Jan 16. doi: 10.1002/mrm.27651. [Epub ahead of print]. pubmed
Meyer DM, Brei C, Stecher L, Much D, Brunner S, Hauner H. Associations between long-chain PUFAs in maternal blood, cord blood, and breast milk and offspring body composition up to 5 years: follow-up from the INFAT study. Eur J Clin Nutr. 2019 Jan 14. doi: 10.1038/s41430-018-0388-3. [Epub ahead of print] pubmed
Kunath J, Günther J, Rauh K, Hoffmann J, Stecher L, Rosenfeld E, Kick L, Ulm K, Hauner H. Effects of a lifestyle intervention during pregnancy to prevent excessive gestational weight gain in routine care - the cluster-randomised GeliS trial. BMC Med. 2019 Jan 14;17(1):5. doi: 10.1186/s12916-018-1235-z. pubmed
Kongressbeiträge und sonstige Veröffentlichungen | KEM | 2019
Hauner H, Beyer-Reiners E, Bischoff G, Breidenassel C, Ferschke M, Gebhardt A, Holzapfel C, Lambeck A, Meteling-Eeken M, Paul C, Rubin D, Schütz T, Volkert D, Wechsler J, Wolfram G, Adam O: Leitfaden Ernährungstherapie in Klinik und Praxis (LEKuP). Aktuel Ernahrungsmed 2019; 44: 384–419
Fiedler K, Hauner H, Hertwig R, Huber G, Mata J, Rösler F, Roosen J, Stroebe W, von Braun J: Übergewicht und Adipositas: Thesen und Empfehlungen zur Eindämmung der Epidemie. Berlin. 2019
Koletzko B, Cremer M, Flothkötter M, Graf C, Hauner H, Hellmers C, Kersting M, Krawinkel M, Przyrembel H, Röbl-Mathieu M, Schiffner U, Vetter K, Weißenborn A, Wöckel A. Ernährung und Lebensstil vor und während der Schwangerschaft – Zusammenfassung aktualisierte Handlungsempfehlungen. Die Hebamme 2019; 32: 8–15
Günther J, Hoffmann J, Spies M, Hauner H: Lebensstil und Gewichtszunahme in der Schwangerschaft. Bedeutung für die Gesundheit von Mutter und Kind. Ernährung & Medizin. 2019; 34: 20–25
DANK-Pressemitteilung. Repräsentative Umfrage zur Nährwertkennzeichnung: Große Mehrheit für Nutri-Score-Ampel. Klöckner-Modell fällt bei deutschen Verbraucherinnen und Verbrauchern durch. Adipositas 2019; 13: 231–237
Ernst JB, Arens-Azevêdo U, Bitzer B, Bosy-Westphal B, de Zwaan M, Egert S, Fritsche A, Gerlach S, Hauner H, Heseker H, Koletzko B, Müller-Wieland D, Schulze M, Virmani K, Watzl B, Buyken AE: Quantitative Empfehlung zur Zuckerzufuhr in Deutschland.Kurzfassung des Konsensuspapiers der Deutschen Adipositas-Gesellschaft e. V. (DAG), der Deutschen Diabetes Gesellschaft e. V. (DDG) und der Deutschen Gesellschaft für Ernährung e. V. (DGE) for the German Obesity Society (DAG), German Diabetes Society (DDG) und German Nutrition Society (DGE) (2019) Ernahrungs Umschau 66(2): 26–34. DOI: 10.4455/eu.2019.006 lesen
2018
Michel S, Raab R, Drabsch T, Günther J, Stecher L, Hauner H. Do lifestyle interventions during pregnancy have the potential to reduce long‐term postpartum weight retention? A systematic review and meta‐analysis. Obesity Reviews. 2018 Dec 12;1–16. doi.org/10.1111/obr.12809 lesen
Gingrich A, Spiegel A, Gradl JE, Skurk T, Hauner H, Sieber CC, Volkert D, Kiesswetter E.Daily and per-meal animal and plant protein intake in relation to muscle mass in healthy older adults without functional limitations: an enable study.Aging Clin Exp Res. 2018 Dec 5. doi: 10.1007/s40520-018-1081-z pubmed
Rohm F, Skurk T, Daniel H, Spanier B. Appearance of di‐ and Tripeptides in Human Plasma after a Protein Meal does not Correlate with PEPT1 Substrate Selectivity. Molecular Nutrition & Food Research. 2018 Dec 06; doi.org/10.1002/mnfr.201801094 pubmed
Meyer DM, Brei C, Stecher L, Much D, Brunner S, Hauner H.Leptin in Maternal Plasma and Cord Blood as a Predictor of Offspring Adiposity at 5 Years: A Follow-up Study. Obesity (Silver Spring). 2018 Feb;26(2):279-283. doi: 10.1002/oby.22037. Epub 2017 Dec 3. pubmed
Drabsch T, Holzapfel C, Stecher L, Petzold J, Skurk T, Hauner H. Associations Between C-Reactive Protein, Insulin Sensitivity, and Resting Metabolic Rate in Adults: A Mediator Analysis. Front Endocrinol. 2018 Sep 20. 9:556. doi: 10.3389/fendo.2018.00556. eCollection 2018. pubmed
Philipsborn P, Stratil JM, Heise TL, Landgraf R, Hauner H, Rehfuess EA. Voluntary industry initiatives to promote healthy diets: a case study on a major European food retailer. Public Health Nutr. 2018 Oct 18:1-8. doi: 10.1017/S1368980018002744. pubmed
Worsch S, Heikenwalder M, Hauner H, Bader BL. Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice. Nutr Metab (Lond). 2018 Sep 26.15:65. doi: 10.1186/s12986-018-0291-x. eCollection 2018. pubmed
Neumann M, Holzapfel C, Müller A, Hilbert A, Crosby RD, de Zwaan M. Features and Trajectories of Eating Behavior in Weight-Loss Maintenance: Results from the German Weight Control Registry. Obesity 2018;26(9):1501-1508. doi: 10.1002/oby.22270. pubmed
Gingrich A, Rennekamp R, Brandl B, Skurk T, Hauner H, Sieber CC, Volkert D, Kiesswetter E. Do Aspects of Protein Intake Vary Across the Week in Healthy Community-Dwelling Older Adults? An enable Study. Nutrients. 2018 Sep 3;10(9). pii: E1217. doi: 10.3390/nu10091217. pubmed
Brei C, Much D, Brunner S, Stecher L, Hauner H. Longitudinal sonographic assessment of abdominal fat distribution from 2 to 5 years of age. Pediatr Res. 2018. DOI: 10.1038/s41390-018-0147-0. pubmed
Drabsch T, Gatzemeier J, Pfadenhauer L, Hauner H, Holzapfel C. Associations between Single Nucleotide Polymorphisms and Total Energy, Carbohydrate, and Fat Intakes: A Systematic Review, Advances in Nutrition, Volume 9, Issue 4, 1 July 2018, Pages 425–453. pubmed
Ambrosini GL, Solis-Trapala I, Ahern AL, Fuller NR, Holzapfel C, Hauner H, Caterson ID, Jebb SA. Greater improvements in diet quality among overweight participants following a group-based commercial weight loss programme than those receiving support to lose weight in primary care. Nutr J 2018.17(1):64. DOI: 10.1186/s12937-018-0370-x. pubmed
Meyer DM, Brei C, Stecher L, Brunner S, Hauner H. Maternal insulin resistance, triglycerides and cord blood insulin are not determinants of offspring growth and adiposity up to 5 years: a follow-up study. Diabet Med. 2018 DOI: 10.1111/dme.13765.
Riedl A, Wawro N, Gieger C, Meisinger C, Peters A, Roden M, Kronenberg F, Herder C, Rathmann W, Völzke H, Reincke M, Koenig W, Wallaschofski H, Hauner H, Daniel H, Linseisen J. Identification of Comprehensive Metabotypes Associated with Cardiometabolic Diseases in the Population-Based KORA Study. Mol Nutr Food Res. 2018 DOI: 10.1002/mnfr.201800117. pubmed
Brei C, Stecher L, Meyer DM, Young V, Much D, Brunner S, Hauner H. Impact of Dietary Macronutrient Intake during Early and Late Gestation on Offspring Body Composition at Birth, 1, 3, and 5 Years of Age. Nutrients. 2018 May 8;10(5). pii: E579. doi:10.3390/nu10050579. pubmed
Weigl J, Hauner H, Hauner D. Can Nutrition Lower the Risk of Recurrence in Breast Cancer? Breast Care 2018. 13:86-91. doi:10.1159/000488718 lesen
Baum T, Rohrmeier A, Syväri J, Diefenbach MN, Franz D, Dieckmeyer M, Scharr A, Hauner H, Ruschke S, Kirschke JS, Karampinos DC. Anatomical Variation of Age-Related Changes in Vertebral Bone Marrow Composition Using Chemical Shift Encoding-Based Water-Fat Magnetic Resonance Imaging. Front Endocrinol (Lausanne). 2018. 4;9:141. doi:10.3389/fendo.2018.00141. pubmed
Reber J, Willershäuser M, Karlas A, Paul-Yuan K, Diot G, Franz D, Fromme T, Ovsepian SV, Bézière N, Dubikovskaya E, Karampinos DC, Holzapfel C, Hauner H, Klingenspor M, Ntziachristos V. Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients. Cell Metab. 2018;27(3):689-701.e4. doi:10.1016/j.cmet.2018.02.002. pubmed
Ott B, Skurk T, Lagkouvardos L, Fischer S, Büttner J, Lichtenegger M, Clavel T, Lechner A, Rychlik M, Haller D, Hauner H. Short-Term Overfeeding with Dairy Cream Does Not Modify Gut Permeability, the Fecal Microbiota, or Glucose Metabolism in Young Healthy Men. J Nutr. 2018 Jan 1;148(1):77-85. doi: 10.1093/jn/nxx020 pubmed
Hauner H, Martignoni M. Ernährung in der Onkologie. W. Zuckschwerdt-Verlag. 1. Auflage. München. 2018
Buchbeiträge und sonstige Veröffentlichungen | KEM | 2018
Brei C, Baerlocher K, Steinhart H, Urbanen R. Teil 10: Konsum von Milchfrischprodukten und Allergien. ErnährungsUmschau. 2018. 65(3): M156–M161. Übersichtsarbeit
Holzmann SL, Bieringer A, Hauner H, Holzapfel C. Nudging-Maßnahmen im Bereich Ernährung zur Prävention von Übergewicht und Adipositas bei Kindern und Jugendlichen. Adipositas 2018 12: 17-23 DOI: 10.1055/s-0038-1636967. Übersichtsarbeit
Brei C, Sieber CS, Hauner H. Teil 8: Konsum von Milchfrischprodukten und Osteoporose. Ernährungs Umschau. 2018. 65(1): M38–M40. Übersichtsarbeit
Weigl J, Hauner H, Hauner D. Can Nutrition Lower the Risk of Recurrence in Breast Cancer? Breast Care 2018. 13:86-91. doi:10.1159/000488718 lesen
Brei C, Baerlocher K, Meier RF. Teil 9: Konsum von Milchfrischprodukten und Laktoseintoleranz. ErnährungsUmschau. 2018. 65(1): M41–M43. Übersichtsarbeit
Wöckel A, Festl J, Stüber T, Brust K, Stangl S, Heuschmann PU, Albert US, Budach W, Follmann M, Janni W, Kopp I, Kreienberg R, Kühn T, Langer T, Nothacker M, Scharl A, Schreer I, Link H, Engel J, Fehm T, Weis J, Welt A, Steckelberg A, Feyer P, König K, Hahne A, Kreipe HH, Knoefel WT, Denkinger M, Brucker S, Lüftner D, Kubisch C, Gerlach C, Lebeau A, Siedentopf F, Petersen C, Bartsch HH, Schulz-Wendtland R, Hahn M, Hanf V, Müller-Schimpfle M, Henscher U, Roncarati R, Katalinic A, Heitmann C, Honegger C, Paradies K, Bjelic-Radisic V, Degenhardt F, Wenz F, Rick O, Hölzel D, Zaiss M, Kemper G, Budach V, Denkert C, Gerber B, Tesch H, Hirsmüller S, Sinn HP, Dunst J, Münstedt K, Bick U, Fallenberg E, Tholen R, Hung R, Baumann F, Beckmann MW, Blohmer J, Fasching PA, Lux MP, Harbeck N, Hadji P, Hauner H, Heywang-Köbrunner S, Huober J, Hübner J, Jackisch C, Loibl S, Lück HJ, von Minckwitz G, Möbus V, Müller V, Nöthlings U, Schmidt M, Schmutzler R, Schneeweiss A, Schütz F, Stickeler E, Thomssen C, Untch M, Wesselmann S, Bücker A, Krockenberger M. Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) - Part 1 with Recommendations for the Screening, Diagnosis and Therapy of Breast Cancer. Geburtshilfe Frauenheilkd. 2018 Oct;78(10):927-948. doi: 10.1055/a-0646-4522. Epub 2018 Oct 19.pubmed
Ernst JB, Arens-Azevêdo U, Bitzer B, Bosy-Westphal A, de Zwaan M, Egert S, Fritsche A, Gerlach S, Hauner H, Heseker H, Koletzko B, Müller-Wieland D, Schulze M, Virmani K, Watzl B, Buyken AE für Deutsche Adipositas-Gesellschaft, Deutsche Diabetes Gesellschaft und Deutsche Gesellschaft für Ernährung. Quantitative Empfehlung zur Zuckerzufuhr in Deutschland. Bonn, 2018 lesen
Koletzko B, Cremer M, Flothkötter M, Graf C, Hauner H, Hellmers C, Kersting M, Krawinkel M, Przyrembel H, Röbe- Mathieu M, Schiffner U, Vetter K, Weißenborn A, Wöckel A: Die neuen Handlungsempfehlungen - Ernährung und Lebensstil vor und während der Schwangerschaft lesen
2017
Hauner H, Hastreiter L, Werdier D, Chen-Stute A, Scholze J, Blüher M. Efficacy and Safety of Cathine (Nor-Pseudoephedrine) in the Treatment of Obesity: A Randomized Dose-Finding Study. Obes Facts. 2017;10(4):407-419. doi: 10.1159/000478098. pubmed
Laxy M, Stark R, Peters A, Hauner H, Holle R, Teuner CM. The Non-Linear Relationship between BMI and Health Care Costs and the Resulting Cost Fraction Attributable to Obesity. Int J Environ Res Public Health. 2017 Aug 30;14(9). pii: E984. doi: 10.3390/ijerph14090984. pubmed
Gingrich A, Spiegel A, Kob R, Schoene D, Skurk T, Hauner H, Sieber CC, Volkert D, Kiesswetter E. Amount, Distribution, and Quality of Protein Intake Are Not Associated with Muscle Mass, Strength, and Power in Healthy Older Adults without Functional Limitations-An enable Study. Nutrients. 2017. pii: E1358. DOI: 10.3390/nu9121358.
Meyer DM, Brei C, Stecher L, Much D, Brunner S, Hauner H. Leptin in Maternal Plasma and Cord Blood as a Predictor of Offspring Adiposity at 5 Years: A Follow-up Study. Obesity. DOI:10.1002/oby.22037 pubmed
Ott B, Skurk T, Hastreiter L, Lagkouvardos I, Fischer S, Büttner J, Kellerer T, Clavel T, Rychlik M, Haller D, Hauner H. Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women. SCIENTIFIC Repo R ts | 7: 11955 | DOI:10.1038/s41598-017-12109-9 pubmed
Franz D, Weidlich D, Freitag F, Holzapfel C, Drabsch T, Baum T, Eggers H, Witte A, Rummeny
EJ, Hauner H, Karampinos DC. Association of proton density fat fraction in adipose tissue with imaging-based and anthropometric obesity markers in adults. Int J Obes (Lond). 2017. DOI: 10.1038/ijo.2017.194. [Epub ahead of print] pubmed
Hauner H, Hastreiter L, Werdier D, Chen-Stute A, Scholze J, Blüher M. Efficacy and Safety of Cathine (Nor-Pseudoephedrine) in the Treatment of Obesity: A Randomized Dose-Finding Study. Obes Facts 2017. (4):407-419. DOI: 10.1159/000478098. [Epub ahead of print] pubmed
Prankl V, Dressel K, Hauner H. An Analysis of the Food Start-up Scene in the Munich Region Focus on Health? ERNAHRUNGS UMSCHAU Volume: 64 Issue: 8 Pages: M460-M464. AUG 2017. DOI: 10.4455/eu.201Z033
Meyer DM, Brei C, Stecher L, Much D, Brunner S, Hauner H. The relationship between breast milk leptin and adiponectin with child body composition from 3 to 5years: a follow-up study. PEDIATRIC OBESITY. AUG 2017. Volume: 12 Pages: 125-129 DOI: 10.1111/ijpo.12192 Supplement: 1 pubmed
Rogozińska E, Marlin N, Jackson L, Rayanagoudar G, Ruifrok AE, Dodds J, Molyneaux E, van Poppel MN, Poston L, Vinter CA, McAuliffe F, Dodd JM, Owens J, Barakat R, Perales M, Cecatti JG, Surita F, Yeo S, Bogaerts A, Devlieger R, Teede H, Harrison C, Haakstad L, Shen GX, Shub A, Beltagy NE, Motahari N, Khoury J, Tonstad S, Luoto R, Kinnunen TI, Guelfi K, Facchinetti F, Petrella E, Phelan S, Scudeller TT, Rauh K, Hauner H, Renault K, de Groot CJ, Sagedal LR, Vistad I, Stafne SN, Mørkved S, Salvesen KÅ, Jensen DM, Vitolo M, Astrup A, Geiker NR, Kerry S, Barton P, Roberts T, Riley RD, Coomarasamy A, Mol BW, Khan KS, Thangaratinam S. Effects of antenatal diet and physical activity on maternal and fetal outcomes: individual patient data meta-analysis and health economic evaluation. Health Technol Assess. 2017.(41):1-158. DOI: 10.3310/hta21410. pubmed
Rogozinska E, Marlin N, Betran AP, Astrup A, Bogaerts A, Cecatti JG, Devlieger R, Dodd JM, El Beltagy N, Facchinetti F, Geiker NRW, Guelfi KJ, Haakstad LAH, Harrison CL, Hauner H, Jensen DM, Kinnunen TI, Khoury J, Luoto R, McAuliffe F, Motahari N, Morkved S, Owens J, Perales M, Petrella E, Phelan S, Poston L, Rauh K, Renault KM, Sagedal LR, Salvesen KA, Shen GX, Shub A, Scudeller T, Surita FG, Stafne SN, Teede H, Tonstad S, van Poppel MNM, Vinter CA, Vistad I, Yeo S, Dodds J, Kerry S, Jackson L, Barton P, Molyneaux E, Martin AA, Rayanagoudar G, Ruifrok AE, Roberts T, de Groot CJM, Coomarasamy A, Mol BWJ, Zamora J, Khan KS, Riley RD, Thangaratinam S. Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials The International Weight Management in Pregnancy (i-WIP) Collaborative Group. 2017. BMJ-BRITISH MEDICAL JOURNAL Volume: 358 Article Number: j3119 DOI: 10.1136/bmj.j3119
Lee H, Qian K, von Toerne C, Hoerburger L, Claussnitzer M, Hoffmann C, Glunk V, Wahl S, Breier M, Eck F, Jafari L, Molnos S, Grallert H, Dahlman I, Arner P, Brunner C, Hauner H, Hauck SM, Laumen H. Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation. Nucleic Acids Res. 2017.45(6):3266-3279. DOI: 10.1093/nar/gkx105. PMID: 28334807 Free PMC Article. pubmed
Riedl A, Gieger C, Hauner H, Daniel H, Linseisen J. Metabotyping and its application in targeted nutrition: an overview. Br J Nutr. 2017. 19:1-14. DOI: 10.1017/S0007114517001611. pubmed
Rogozińska E, Marlin N, Yang F, Dodd JM, Guelfi K, Teede H, Surita F, Jensen DM, Geiker NRW, Astrup A, Yeo S, Kinnunen TI, Stafne SN, Cecatti JG, Bogaerts A, Hauner H, Mol BW, Scudeller TT, Vinter CA, Renault KM, Devlieger R, Thangaratinam S, Khan KS; i-WIP (International Weight Management in Pregnancy) Collaborative Group. Variations in reporting of outcomes in randomized trials on diet and physical activity in pregnancy: A systematic review. J Obstet Gynaecol Res. 2017. DOI: 10.1111/jog.13338. pubmed
Brei C, Stecher L, Brunner S, Ensenauer R, Heinen F, Wagner PD, Hermsdörfer J, Hauner H. Impact of the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on offspring neurodevelopment: 5-year follow-up of a randomized controlled trial, Eur J Clin Nutr. 2017 May 24. doi: 10.1038/ejcn.2017.79. [Epub ahead of print] pubmed
Hauner H, OBESITY FACTS – 10 Successful Years, Obes Facts 2017;10:50–51, DOI: 10.1159/000463398, Published online: February 21, 2017 pubmed
Graff M, Scott RA, Justice AE, …, Holzapfel C, … Kilpeläinen TO. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet. 2017.13(4):e1006528. DOI: 0.1371/journal.pgen.1006528. eCollection 2017 Apr. pubmed
Holzmann SL, Pröll K, Hauner H, Holzapfel C. Ernährungs-Apps: Qualität und Limitationen. Eine explorative Erhebung anhand ausgewählter Beispiel-Apps. 2017 Ernährungs Umschau 64(5): 80–89.
Lee H, Qian K, von Toerne C, Hoerburger L, Claussnitzer M, Hoffmann C, Glunk V, Wahl S, Breier M, Eck F, Jafari L, Molnos S, Grallert H, Dahlman I, Arner P, Brunner C, Hauner H, Hauck SM, Laumen H. Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation. Nucleic Acids Res. 2017. DOI: 10.1093/nar/gkx105. pubmed
Yates N, Teuner CM, Hunger M, Holle R, Stark R, Laxy M, Hauner H, Peters A, Wolfenstetter SB. The Economic Burden of Obesity in Germany: Results from the Population-Based KORA Studies. Obes Facts 2016. 9(6):397-409. DOI: 10.1159/000452248. Epub 2016 Dec 13. pubmed
Visscher TL, Lakerveld J, Olsen N, Küpers L, Ramalho S, Keaver L, Brei C, Bjune JI, Ezquerro S, Yumuk V. Perceived Health Status: Is Obesity Perceived as a Risk Factor and Disease. Obes Facts. 2017. 10(1):52-60. DOI: 10.1159/000457958. pubmed
Meyer DM, Brei C, Stecher L, Much D, Brunner S, Hauner H. Cord blood and Child Plasma Adiponectin Levels in Relation to Childhood Obesity Risk and Fat Distribution up to 5 years. Pediatr Res. 2017. DOI: 10.1038/pr.2016.275. [Epub ahead of print]. pubmed
2016
Six-Merker J, Meisinger C, Jourdan C, Heier M, Hauner H, Peters A, Linseisen J. Treatment of Thyroid Dysfunctions Decreases the Risk of Cerebrovascular Events in Men but Not in Women: Results of the MONICA/KORA Cohort Study. PLoS One. 2016. 11(5):e0155499. DOI: 10.1371/journal.pone.0155499. eCollection 2016.PMID: 27191851 [PubMed - indexed for MEDLINE] Free PMC Article pubmed
Nielson CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S, Jakobsdottir J, Wassel C, Register TC, Oei L, Alonso N, Oei EH, Parimi N, Samelson EJ, Nalls MA, Zmuda J, Lang T, Bouxsein M, Latourelle J, Claussnitzer M, Siggeirsdottir K, Srikanth P, Lorentzen E, Vandenput L, Langefeld C, Raffield L, Terry G, Cox AJ, Allison MA, Criqui MH, Bowden D, Ikram MA, Mellström D, Karlsson MK, Carr J, Budoff M, Phillips C, Cupples LA, Chou WC, Myers RH, Ralston SH, Gautvik KM, Cawthon PM, Cummings S, Karasik D, Rivadeneira F, Gudnason V, Orwoll ES, Harris TB, Ohlsson C, Kiel DP, Hsu YH. Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2. J Bone Miner Res. 2016. 31(12):2085-2097. DOI: 10.1002/jbmr.2913. Epub 2016 Sep 6. pubmed
Yates N, Teuner CM, Hunger M, Holle R, Stark R, Laxy M, Hauner H, Peters A, Wolfenstetter SB. The Economic Burden of Obesity in Germany: Results from the Population-Based KORA Studies. Obes Facts. 2016. 9(6):397-409. pubmed
Hauner H. High-fat mediterranean diet leads to slight weight reduction. Dtsch Med Wochenschr. 2016.141(18):1278. DOI:10.1055/s-0042-111570. Epub 2016 Sep 6. German. No abstract available. pubmed
Cordes C, Baum T, Dieckmeyer M, Ruschke S, Diefenbach MN, Hauner H, Kirschke JS, Karampinos DC. MR-Based Assessment of Bone Marrow Fat in Osteoporosis, Diabetes, and Obesity.Front Endocrinol (Lausanne). 2016. 7:74. DOI: 10.3389/fendo.2016.00074. eCollection 2016. pubmed
Berti C, Cetin I, Agostoni C, Desoye G, Devlieger R, Emmett PM, Ensenauer R, Hauner H, Herrera E, Hoesli I, Krauss-Etschmann S, Olsen SF, Schaefer-Graf U, Schiessl B, Symonds ME, Koletzko B. Pregnancy and Infants' Outcome: Nutritional and Metabolic Implications. 2016. 56(1):82-91. DOI: 10.1080/10408398.2012.745477. pubmed
Six-Merker J, Meisinger C, Jourdan C, Heier M, Hauner H, Peters A, Linseisen J. Treatment of Thyroid Dysfunctions Decreases the Risk of Cerebrovascular Events in Men but Not in Women: Results of the MONICA/KORA Cohort Study. PLoS One. 2016. 11(5):e0155499. DOI: 10.1371/journal.pone.0155499. eCollection 2016. pubmed
Flynn AC, Dalrymple K, Barr S, Poston L, Goff LM, Rogozińska E, van Poppel MN, Rayanagoudar G, Yeo S, Barakat Carballo R, Perales M, Bogaerts A, Cecatti JG, Dodd J, Owens J, Devlieger R, Teede H, Haakstad L, Motahari-Tabari N, Tonstad S, Luoto R, Guelfi K, Petrella E, Phelan S, Scudeller TT, Hauner H, Renault K, Sagedal LR, Stafne SN, Vinter C, Astrup A, Geiker NR, McAuliffe FM, Mol BW, Thangaratinam S, i-WIP (International Weight Management in Pregnancy) Collaborative Group. Dietary interventions in overweight and obese pregnant women: a systematic review of the content, delivery, and outcomes of randomized controlled trials. Nutr Rev. 2016. 74(5):312-28. DOI: 10.1093/nutrit/nuw005. Review. pubmed
Pfeiffer, AFH, Gebauer, S, Rubin, D, Schulze, M, Buchholz, G, Klein, H, von Lilienfeld-Toal, H, Reinert, G, Simon, MC, Mussig, K, Skurk, T, Hauner, H, Tombek, A, Muller, MJ, Fischer, S, Weickert, MO, Hoffmann, D. Nutritional recommendations for the treatment of diabetes mellitus - recommendations for protein intake. DIABETOLOGIE UND STOFFWECHSEL, 2016. 11(4):272-282 DOI: 10.1055/s-0042-111088
Shen J, Baum T, Cordes C, Ott B, Skurk T, Kooijman H, Rummeny EJ, Hauner H, Menze BH, Karampinos DC. Automatic segmentation of abdominal organs and adipose tissue compartments in water-fat MRI: Application to weight-loss in obesity. Eur J Radiol. 2016. 85(9):1613-21. pubmed
Holzapfel C, Merl M, Stecher L, Hauner H. One-Year Weight Loss with a Telephone-Based Lifestyle Program. Obes Facts. 2016. 9(4):230-240. [Epub ahead of print]
von Philipsborn P, Stratil JM, Burns J, Busert LK, Pfadenhauer LM, Polus S, Holzapfel C, Hauner H, Rehfuess E. Environmental interventions to reduce the consumption of sugar-sweetened beverages and their effects on health (Protocol). Cochrane Database of Systematic Reviews. 2016. Issue 7. Art. No.: CD012292. DOI: 10.1002/14651858.CD012292
Lee YM, Wolf P, Hauner H, Skurk T. Effect of a fermented dietary supplement containing chromium and zinc on metabolic control in patients with type 2 diabetes: a randomized, placebo-controlled, double-blind cross-over study. Food Nutr Res. 2016. DOI:10.3402/fnr.v60.30298. eCollection 2016. pubmed
Rogozinska E1,2, D'Amico MI1, Khan KS1,2, Cecatti JG3, Teede H4, Yeo S5, Vinter CA6,7, Rayanagoudar G1, Barakat R8, Perales M8, Dodd JM9, Devlieger R10, Bogaerts A10, van Poppel MN11, Haakstad L12, Shen GX13, Shub A14, Luoto R15, Kinnunen TI16, Phelan S17, Poston L18, Scudeller TT19, El Beltagy N20, Stafne SN21,22, Tonstad S23, Geiker NR24, Ruifrok AE25,26, Mol BW27, Coomarasamy A28, Thangaratinam S1,2; International Weight Management in Pregnancy (iWIP) Collaborative Group. Collaborators (46) van Poppel M, Carballo RB, Perales M, Bogaerts A, Devlieger R, Cecatti JG, Surita F, Vitolo M, Dodd JM, Owens J, El Beltagy N, Teede H, Harrison C, Haakstad L, Shen GX, Shub A, Motahari N, Khoury J, Tonstad S, Luoto R, Kinnunen TI, Guelfi K, Facchinetti F, Petrella E, Phelan S, Poston L, Scudeller T, Rauh K, Hauner H, Renault K, Sagedal LR, Vistad I, Stafne SN, Salvesen KÅ, Vinter C, McAuliffe F, Astrup A, Geiker NR, Yeo S, Mol BW, Khan KS, Thangaratinam S, Coomarasamy A, Ruifrok A, Rayanagoudar G, Rogozinska E. Development of composite outcomes for individual patient data (IPD) meta-analysis on the effects of diet and lifestyle in pregnancy: a Delphi survey. BJOG. 2016. DOI: 10.1111/1471-0528.13764. pubmed
Halama A, Horsch M, Kastenmüller G, Möller G, Kumar P, Prehn C, Laumen H, Hauner H, Hrabĕ de Angelis M, Beckers J, Suhre K, Adamski J. Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis. Arch Biochem Biophys. 2016. 589:93-107. DOI:10.1016/j.abb.2015.09.013. Epub 2015. pubmed
Strawbridge RJ, Laumen H, Hamsten A, Breier M, Grallert H, Hauner H, Arner P, Dahlman I. Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis. PLoS One. 2016. 11(4):e0153990. DOI:10.1371/journal.pone.0153990. eCollection 2016. pubmed
Brei C, Stecher L, Much D, Karla MT, Amann-Gassner U, Shen J, Ganter C, Karampinos DC, Brunner S, Hauner H. Reduction of the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on offspring body composition: follow-up results from a randomized controlled trial up to 5 y of age. Am J Clin Nutr. 2016. pii: ajcn128520. pubmed
Baum T, Cordes C, Dieckmeyer M, Ruschke S, Franz D, Hauner H, Kirschke JS, Karampinos DC. MR-based assessment of body fat distribution and characteristics. Eur J Radiol. 2016. pii: S0720-048X(16)30042-0. DOI:10.1016/j.ejrad.2016.02.013. pubmed
2015
Cordes C, Dieckmeyer M, Ott B, Shen J, Ruschke S, Settles M, Eichhorn C, Bauer JS, Kooijman H, Rummeny EJ, Skurk T, Baum T, Hauner H, Karampinos DC. MR-detected changes in liver fat, abdominal fat, and vertebral bone marrow fat after a four-week calorie restriction in obese women. J Magn Reson Imaging. 2015. 42(5):1272-80. pubmed
Scholz C, Andergassen U, Hepp P, Schindlbeck C, Friedl TW, Harbeck N, Kiechle M, Sommer H, Hauner H, Friese K, Rack B, Janni W. Obesity as an independent risk factor for decreased survival in node-positive high-risk breast cancer. Breast Cancer Res Treat. 2015.151(3):569-76. DOI:10.1007/s10549-015-3422-3. Epub 2015 May 13. pubmed
Rauh K, Günther J, Kunath J, Stecher L, Hauner H. Lifestyle intervention to prevent excessive maternal weight gain: mother and infant follow-up at 12 months postpartum. BMC Pregnancy Childbirth. 2015, 15;15(1):265. DOI:10.1186/s12884-015-0701-2 pubmed
Fiamoncini J, Lima TM, Hirabara SM, Ecker J, Gorjão R, Romanatto T, ELolimy A, Worsch S, Laumen H, Bader B, Daniel H, Curi R. Medium-chain dicarboxylic acylcarnitines as markers of n-3 PUFA-induced peroxisomal oxidation of fatty acids. Mol Nutr Food Res. 2015 Aug;59(8):1573-83. DOI:10.1002/mnfr.201400743. Epub 2015 May 26. pubmed
Wolfram G, Bechthold A, Boeing H, Ellinger S, Hauner H, Kroke A, Leschik-Bonnet E, Linseisen J, Lorkowski S, Schulze M, Stehle P, Dinter J. Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases. Ann Nutr Metab 2015;67:141-204. (DOI:10.1159/000437243) pubmed
Halama A, Horsch M, Kastenmüller G, Möller G, Kumar P, Prehn C, Laumen H, Hauner H, Hrabĕ de Angelis M, Beckers J, Suhre K, Adamski J. Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis. Arch Biochem Biophys. 2015, pii: S0003-9861(15)30064-3. DOI:10.1016/j.abb.2015.09.013. pubmed
Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa I, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. August 19, 2015 DOI:10.1056/NEJMoa150221. pubmed
Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. Integrative analysis of 111 reference human epigenomes. Nature. 2015, 19;518(7539):317-30. DOI:10.1038/nature14248. pubmed
Xu T, Brandmaier S, Messias AC, Herder C, Draisma HH, Demirkan A, Yu Z, Ried JS, Haller T, Heier M, Campillos M, Fobo G, Stark R, Holzapfel C, Adam J, Chi S, Rotter M, Panni T, Quante AS, He Y, Prehn C, Roemisch-Margl W, Kastenmüller G, Willemsen G, Pool R, Kasa K, van Dijk KW, Hankemeier T, Meisinger C, Thorand B, Ruepp A, Hrabé de Angelis M, Li Y, Wichmann HE, Stratmann B, Strauch K, Metspalu A, Gieger C, Suhre K, Adamski J, Illig T, Rathmann W, Roden M, Peters A, van Duijn CM, Boomsma DI, Meitinger T, Wang-Sattler R. Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes. Diabetes Care. 2015 pubmed
Walker CG, Solis-Trapala I, Holzapfel C, Ambrosini GL, Fuller NR, Loos RJ, Hauner H, Caterson ID, Jebb SA. Modelling the Interplay between Lifestyle Factors and Genetic Predisposition on Markers of Type 2 Diabetes Mellitus Risk. PLoS One. 2015, DOI:10.1371/journal.pone.0131681 pubmed
Brunner S, Stecher L, Ziebarth S, Nehring I, Rifas-Shiman SL, Sommer C, Hauner H, von Kries R. Excessive gestational weight gain prior to glucose screening and the risk of gestational diabetes: a meta-analysis. Diabetologia. 2015 pubmed
Fischer B, Schöttl T, Schempp C, Fromme T, Hauner H, Klingenspor M, Skurk T. Inverse relationship between body mass index and mitochondrial oxidative phosphorylation capacity in human subcutaneous adipocytes. Am J Physiol Endocrinol Metab. 2015, ajpendo.00524.2014. DOI:10.1152/ajpendo.00524.2014 pubmed
Hoefle AS, Bangert AM, Stamfort A, Gedrich K, Rist MJ, Lee YM, Skurk T, Daniel H. Metabolic responses of healthy or prediabetic adults to bovine whey protein and sodium caseinate do not differ. J Nutr. 2015, 145(3):467-75. DOI:10.3945/jn.114.199190 pubmed
Brei C, Much D, Heimberg E, Schulte V, Brunner S, Stecher L, Vollhardt C, Bauer JS, Amann-Gassner U, Hauner H. Sonographic assessment of abdominal fat distribution during the first year of infancy. Pediatr Res. 2015, DOI: 10.1038/pr.2015.108 pubmed
Scholz C, Andergassen U, Hepp P, Schindlbeck C, Friedl TW, Harbeck N, Kiechle M, Sommer H, Hauner H, Friese K, Rack B, Janni W. Obesity as an independent risk factor for decreased survival in node-positive high-risk breast cancer. Breast Cancer Res Treat. 2015, DOI:10.1007/s10549-015-3422-3 pubmed
Cordes C, Dieckmeyer M, Ott B, Shen J, Ruschke S, Settles M, Eichhorn C, Bauer JS, Kooijman H, Rummeny EJ, Skurk T, Baum T, Hauner H, Karampinos DC. MR-detected changes in liver fat, abdominal fat, and vertebral bone marrow fat after a four-week calorie restriction in obese women. J Magn Reson Imaging. 2015, DOI:10.1002/jmri.24908 pubmed
Dieckmeyer M, Ruschke S, Cordes C, Yap SP, Kooijman H, Hauner H, Rummeny EJ, Bauer JS, Baum T, Karampinos DC. The need for T 2 correction on MRS-based vertebral bone marrow fat quantification: implications for bone marrow fat fraction age dependence. NMR Biomed. 2015, DOI:10.1002/nbm.3267 pubmed
Bauer JS, Noël PB, Vollhardt C, Much D, Degirmenci S, Brunner S, Rummeny EJ, Hauner H. Accuracy and reproducibility of adipose tissue measurements in young infants by whole body magnetic resonance imaging. PLoS One. 2015, 10(2):e0117127. DOI:10.1371/journal.pone.0117127 pubmed
Jordan J, Nilsson PM, Kotsis V, Olsen MH, Grassi G, Yumuk V, Hauner H, Zahorska-Markiewicz B, Toplak H, Engeli S, Finer N. Joint scientific statement of the European Association for the Study of Obesity and the European Society of Hypertension: obesity and early vascular ageing. J Hypertens. 2015, 33(3):425-34. DOI:10.1097/HJH.0000000000000473 pubmed
Bosy-Westphal A, Kahlhöfer J, Lagerpusch M, Skurk T, Müller MJ. Deep body composition phenotyping during weight cycling: relevance to metabolic efficiency and metabolic risk. Obes Rev. 2015, Suppl 1:36-44. DOI:10.1111/obr.12254 pubmed
Lagkouvardos I, Kläring K, Heinzmann SS, Platz S, Scholz B, Engel KH, Schmitt-Kopplin P, Haller D, Rohn S, Skurk T, Clavel T. Gut metabolites and bacterial community networks during a pilot intervention study with flaxseeds in healthy adult men. Mol Nutr Food Res. 2015 May 18. DOI:10.1002/mnfr.201500125. pubmed
2014
Hauner D, Hauner H. Metabolic syndrome and breast cancer: is there a link? Breast Care (Basel). 2014, 9(4):277-81. DOI: 10.1159/000365951 pubmed
Sedlmeier EM, Brunner S, Much D, Pagel P, Ulbrich SE, Meyer HH, Amann-Gassner U,Hauner H, Bader BL. Human placental transcriptome shows sexually dimorphic gene expression and responsiveness to maternal dietary n-3 long-chain polyunsaturated fatty acid intervention during pregnancy. BMC Genomics. 2014, 15(1):941 [Epub] pubmed
Cordes J, Thünker J, Regenbrecht G, Zielasek J, Correll CU, Schmidt-Kraepelin C, Lange-Asschenfeldt C, Agelink MW, Kahl KG, Gaebel W, Klimke A, Hauner H. Can an early weight management program (WMP) prevent olanzapine (OLZ)-induced disturbances in body weight, blood glucose and lipid metabolism? Twenty-four- and 48-week results from a 6-month randomized trial. World J Biol Psychiatry. 2014, 15(3):229-41. DOI: 10.3109/15622975.2011.592546 pubmed
Dahlhoff C, Worsch S, Sailer M, Hummel BA, Fiamoncini F, Uebel K, Obeid R, Scherling C, Geisel J, Bader BL, Daniel H. Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. Mol Metab. 2014, 3(5):565-80. DOI: 10.1016/j.molmet.2014.04.010 pubmed
Fuller NR, Carter H, Schofield D, Hauner H, Jebb SA, Colaqiuri S, Caterson ID. Cost effectiveness of primary care referral to a commercial provider for weight loss treatment, relative to standard care: a modelled lifetime analysis. Int J Obes (Lond). 2014, 38(8): 1104-9 pubmed
Köster I, Huppertz E, Hauner H, Schubert I. Costs of Diabetes Mellitus (CoDiM) in Germany, Direct Per-capita Costs of Managing Hyperglycaemia and Diabetes Complications in 2010 Compared to 2001. Exp Clin Endocrinol Diabetes. 2014, [Epub] pubmed
Mathew S, Krug S, Skurk T, Halama A, Stank A, Artati A, Prehn C, Malek JA, Kastenmüller G, Römisch-Margl W, Adamski J, Hauner H, Suhre K. Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake. J Transl Med. 2014, 12(1): 161 pubmed
Pais R, Zietek T, Hauner H, Daniel H, Skurk T. RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice. Am J Physiol Gastrointest Liver Physiol. 2014, pii: ajpgi.00329.2013 pubmed
Fuller NR, Williams K, Shrestha R, Ahern AL, Holzapfel C, Hauner H, Jebb SA, Caterson ID. Changes in physical activity during a weight loss intervention and follow-up: a randomized controlled trial. Clin Obes. 2014, DOI:10.1111/cob.12057
Kretschmer A, Möller G, Lee H, Laumen H, von Toerne C, Schramm K, Prokisch H, Eyerich S, Wahl S, Baurecht H, Franke A, Claussnitzer M, ..., Weidinger S. A common atopy-associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding. Allergy. 2014, 69(5): 632-42 pubmed
Brunner S, Schmid D, Zang K, Much D, Knoeferl B, Kratzsch J, Amann-Gassner U, Bader BL, Hauner H. Breast milk leptin and adiponectin in relation to infant body composition up to 2 years. Pediatr Obes. 2014, DOI: 10.1111/j.2047-6310.2014.222.x pubmed
Uebel K, Pusch K, Gedrich K, Schneider KT, Hauner H, Bader BL. Effect of maternal obesity with and without gestational diabetes on offspring subcutaneous and preperitoneal adipose tissue development from birth up to year-1. BMC Pregn Childbirth. 2014, 14(1): 138 pubmed
Dankel SN, Svärd J, Matthä S, Claussnitzer M, Klöting N, Glunk V, Fandalyuk Z, Grytten E, Solsvik MH, Nielsen HJ, Busch C, Hauner H, Blüher M, Skurk T, Sagen JV, Mellgren G. COL6A3 Expression in adipocytes associates with insulin resistance and depends on PPARϒ and adipocyte size. Obes. 2014, DOI: 10.1002/oby.20758 pubmed
Rauh K, Kunath J, Rosenfeld E, Kick L, Ulm K, Hauner H. Healthy living in pregnancy: a cluster-randomized controlled trial to prevent excessive gestational weight gain - rationale and design of the GeliS sudy. BMC Pregn Childbirth. 2014, 14: 119 pubmed
Berti C, ..., Hauner H, ..., Koletzko B. Pregnancy and infants` outcome: nutritional and metabolic implications. Crit Rev Food Sci Nutr. 2014, [Epub] pubmed
Krinninger P, Ensenauer R, Ehlers K, Rauh K, Stoll J, Krauss-Etschmann S, Hauner H, Laumen H. Peripheral monocytes of obese women display increased chemokine receptor expression and migration capacity. J Clin Endocrinol Metab. 2014, [Epub] pubmed
Spieler D, Kaffe M, ..., Claussnitzer M, ..., Laumen H, ..., Winkelmann J. Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome res. 2014, 24(4): 592-603 pubmed
Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H,..., Skurk T, ..., Hauner H, Laumen H. Leveraging Cross-Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms. Cell. 2014, 156(1-2): 343-5 pubmed
Hauner H. OBESITY FACTS - a Retrospective and the Way Forward. Obes Facts. 2014, 7(1): 69-70 [Epub] pubmed
Ehlers K, Brand T, Bangert A, Hauner H, Laumen H. Postprandial activation of metabolic and inflammatory signalling pathways in human peripheral mononuclear cells. Br J Nutr. 2014, 111(12):2167-75 pubmed
2013
Dahlhoff C, Desmarchelier C, Sailer M, Fürst RW, Haag A, Ulbrich SE, Hummel B, Obeid R, Geisel J, Bader BL, Daniel H. Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism. PLoS One. 2013, 8(3):e57387. DOI: 10.1371/journal.pone.0057387. pubmed
Desmarchelier C, Ludwig T, Scheundel R, Rink N, Bader BL, Klingenspor M, Daniel H. Diet-induced obesity in ad libitum-fed mice: food texture overrides the effect of macronutrient composition. Br J Nutr. 2013, 109(8):1518-27. DOI: 10.1017/S0007114512003340. pubmed
Much D, Brunner S, Vollhardt C, Schmid D, Sedlmeier EM, Brüderl M, Heimberg E, Bartke N, Boehm G, Bader BL, Amann-Gassner U, Hauner H. Breast milk fatty acid profile in relation to infant growth and body composition: results from the INFAT study. Pediatr Res. 2013, 74(2): 230-7 DOI: 10.1038/pr.2013.82. pubmed
Wahl S, ..., Hauner H. Comparative analysis of plasma metablomics respose to metabolic challenge tests in healthy subjects and influence of the FTO obesity risk allele. Metabolomics. 2013, DOI: 10.1007/s11306-013-0586-x
Mueller K, Quandt J, Marienfeld RB, Weihrich P, Fiedler K, Claussnitzer M, Laumen H, Vaeth M, Berberich-Siebelt F, Serfling E, Wirth T, Brunner C. Octamer-dependent transcription in T-cells is mediated by NFAT and NF-kB. Nucleic Acids Res. 2013, 41(4): 2138-54 pubmed
Lubinus T, Barnsteiner A, Skurk T, Hauner H, Engel KH. Fate of dietary phytosteryl/ -stanyl esters: analysis of individual intact esters in human feces. Eur J Nutr. 2013, 52(3): 997-1013
Fuller NR, Colagiuri S, Schofield D, Olson AD, Shrestha R, Holzapfel C, Wolfenstetter SB, Holle R, Ahern AL, Hauner H, Jebb SA, Caterson ID. A within-trial cost-effectiveness analysis of primary care referral to a commercial provider for weight loss treatment, relative to standard care - an international randomised controlled trial. Int J Obes. 2013, 37(6): 828-34 pubmed
Ensenauer R, Chmitorz A, Riedel C, Fenske N, Hauner H, Nennstiel-Ratzel U, von Kries R. Effects of suboptimal or excessive gestational weight gain on childhood overweight and abdominal adiposity: results from a retrospective cohort study. Int J Obes. 2013, 37(4): 505-12 pubmed
Brunner S, Schmid D, Hüttinger K, Much D, Brüderl M, Sedlmeier EM, Kratzsch J, Amann-Gassner U, Bader BL, Hauner H. Effect of reducing the n-6/n-3 fatty acid ratio on the maternal and fetal leptin axis in relation to infant body composition. Obes (Silver Spring). 2013, DOI: 10.1002/oby.20481. [Epub] pubmed
Much D, Brunner S, Vollhardt C, Schmid D, Sedlmeier EM, Brüderl M, Heimberg E, Bartke N, Boehm G, Bader BL, Amann-Gassner U, Hauner H. Breast milk fatty acid profile in relation to infant growth and body composition: results from the INFAT study. Pediatr Res. 2013, 74(2): 230-7 pubmed
Ocvrik S, Kistler M, Khan S, Talukder SH, Hauner H. Traditional medicinal plants used for the treatment of diabetes in rural and urban areas of Dhaka, Bangladesh - an ethnobotanical survey. J Ethnobiol Ethnomed. 2013, 9: 43 pubmed
Jaremek M, Yu Z, Mangino M, Mittelstrass K, Prehn C, Singmann P, Xu T, Dahmen N, Weinberger KM, Suhre K, Peters A, Döring A, Hauner H, Adamski J, Illig T, Spector TD, Wang-Sattler R. Alcohol-induced metabolomic differences in humans. Transl Psychiatry. 2013, 3: e276 pubmed
Brunner S, Schmid D, Hüttinger K, Much D, Heimberg E, Sedlmeier EM, Brüderl M, Kratzsch J, Bader BL, Amann-Gassner U, Hauner H. Maternal insulin resistance, triglycerides and cord blood insulin in relation to post-natal weight trajectories and body composition in the offspring up to 2 years. Diabet Med. 2013, 30(12): 1500-7 pubmed
Then C, Wahl S, Kirchhofer A, Grallert H, Krug S, Kastenmüller G, Römisch-Margl W, Claussnitzer M, Illig T, Heier M, Meisinger C, Adamski J, Thorand B, Huth C, Peters A, Prehn C, Heukamp I, Laumen H, Lechner A, Hauner H, Seissler J. Plasma Metabolomics Reveal Alterations of Sphingo- and Glycerophospholipid Levels in Non-Diabetic Carriers of the Transcription Factor 7-Like 2 Polymorphism rs7903146. PLoS One. 2013, 24;8(10): e78430 pubmed
Fuller NR, Carter H, Schofield D, Hauner H, Jebb SA, Colagiuri S, Caterson ID, Cost-effectiveness of primary care referral to a commercial provider for weight loss treatment, relative to standard care - a modelled lifetime analysis. Int J Obes (Lond). 2013, DOI 10.1038/jio.2013.227. [Epub] pubmed
Gstettner A, Holzapfel C, Stoll J, Hauner H. Gewichtsreduktion: Evaluation der Möglichkeiten auf hausärztlicher Versorgungsebene und der Patientenzufriedenheit. Ergebnisse einer Gewichtsreduktionsstudie. Dtsch Med Wochenschr. 2013, 1380: 989–994
Much D, Brunner S, Vollhardt C, Schmid D, Sedlmeier EM, Brüderl M, Heimberg E, Bartke N, Boehm G, Bader BL, Amann-Gassner U, Hauner H. Effect of dietary intervention to reduce the n-6/n-3 fatty acid ratio on maternal and fetal fatty acid profile and its relation to offspring growth and body composition at 1 year of age. Eur J Clin Nutr. 2013, 67: 282-288 pubmed
Xu T, Holzapfel C, Dong X, Bader E, Yu Z, Prehn C, Perstorfer K, Jaremek M, Roemisch-Margl W, Rathmann W, Li Y, Wichmann HE, Wallaschofski H, Ladwig KH, Theis F, Suhre K, Adamski J, Illig T, Peters A, Wang-Sattler R. Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study. BMC Medicine. 2013, 11: 60 pubmed
Wahl S, Holzapfel C, Yu Z, Breier M, Kondofersky I, Fuchs C, Singmann P, Prehn C, Adamski J, Grallert H, Illig T, Wang-Sattler R, Reinehr T. Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children. Metab. DOI 10.1007/s11306-013-0550-9, Published online 06 June 2013
Walker CG, Holzapfel C, Loos RJF, Mander AP, Klopp N, Illig T, Caterson ID, Hauner H, Jebb SA. Genetic Predisposition to an Adverse Lipid Profile Limits the Improvement in Total Cholesterol in Response to Weight Loss. Obes. 2013, doi:10.1002/oby.20328 [Epub] pubmed
Matthae S, May S, Hubersberger M, Hauner H, Skurk T. Protein Normalization in Different Adipocyte Models and Dependence on Cell Size. Horm Metab Res. 2013, 45(08): 572-580 pubmed
Ludwig T, Worsch S, Heikenwalder M, Daniel H, Hauner H, Bader BL. Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice. Am J Physiol Endocrinol Metab. 2013, 304: E1140–E1156 pubmed
Rietveld CA, ...Holzapfel C, ...Koellinger PD. GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment. Science. 2013, 340(6139): 1467-71 pubmed
Rauh K, Gabriel E, Kerschbaum E, Schuster T, von Kries R, Amann-Gassner U, Hauner H. Safety and efficacy of a lifestyle intervention for pregnant women to prevent excessive maternal weight gain: a cluster-randomized controlled trial. BMC Preg Childbirth. 2013, 13: 151 pubmed
Lang R, Dieminger N, Beusch A, Lee YM, Dunkel A, Suess B, Skurk T, Wahl A, Hauner H, Hofmann T. Bioappearance and pharmacokinetics of bioactives upon coffee consumption.Anal Bioanal Chem. 2013, 405(26): 8487-8503 pubmed
Kunert C, Skurk T, Frank O, Lang R, Hauner H, Hofmann T. Development and Application of a Stable Isotope Dilution Analysis for the Quantitation of Advanced Glycation End Products of Creatinine in Biofluids of Type 2 Diabetic Patients and Healthy Volunteers. Anal Chem. 2013, 85: 2961−2969 pubmed
Holzapfel C, Cresswell L, Ahern AL, Fuller NR, Eberhard M, Stoll J, Mander AP, Jebb SA, Caterson ID, Hauner H. The challenge of two year follow-up after intervention for weight loss in primary care. Int J Obes (Lond). 2013, doi: 0.1038/ijo.2013.180. [Epub] pubmed
2012
Brunner S, Holub I, Theis S, Gostner A, Melcher R, Wolf P, Amann-Gassner U, Scheppach W, Hauner H. Metabolic Effects of Replacing Sucrose by Isomaltulose in Subjects With Type 2 Diabetes. A randomized double-blind trial. Diab Care. 2012, 35(6): 1249-1251
Sandgruber S, Much D, Amann-Gassner U, Hauner H, Buettner A. Sensory and molecular characterisation of the protective effect of storage at -80 degrees C on the odour profiles of human milk. Food chem. 2012, 130(2): 236-242
Krug S, Kastenmüller G, Stückler F, Rist MJ, Skurk T, Sailer M, Raffler J, Römisch-Margl W, Adamski J, Prehn C, Frank T, Engel KH, Hofmann T, Luy B, Zimmermann R, Moritz F, Schmitt-Kopplin P, Krumsiek J, Kremer W, Huber F, Oeh U, Theis FJ, Szymczak W, Hauner H, Suhre K, Daniel H. The dynamic range of the human metabolome revealed by challenges. The FASEB Journal. 2012, 26(6): 2607-2619
Noël PB, Bauer JS, Ganter C, Markus C, Rummeny EJ, Hauner H, Engels HP. Clinical Pilot Study for the Automatic Segmentation and Recognition of Abdominal AdiposeTissue Compartments from MRI Data. Fortschr Röntgenstr. 2012, 184(6): 548-555
Hauner H, Much D, Vollhardt C, Brunner S, Schmid D, Sedlmeier EM, Heimberg E, Schuster T, Zimmermann A, Schneider KT, Bader BL, Amann-Gassner U. Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial. Am J Clin Nutr. 2012, 95(2): 383-94
Petersen AK, Stark K, Musameh MD, Nelson CP, Römisch-Margl W, Kremer W, Raffler J, Krug S, Skurk T, Rist MJ, Daniel H, Hauner H, Adamski J, Tomaszewski M, Döring A, Peters A, Wichmann HE, Kaess BM, Kalbitzer HR, Huber F, Pfahlert V, Samani NJ, Kronenberg F, Dieplinger H, Illig T, Hengstenberg C, Suhre K, Gieger C, Kastenmüller G. Genetic associations with lipoprotein subfractions provide information on their biological nature. Hum Mol Genet. 2012, 15;21(6): 1433-43
Skurk T, Hauner H. Primary culture of human adipocyte precursor cells: expansion and differentiation. Methods Mol Biol. 2012, 806: 215-26
Fürst RW, Pistek VL, Kliem H, Skurk T, Hauner H, Meyer HHD. Maternal low-dose estradiol-17β exposure during pregnancy impairs postnatal progeny weight development and body composition. Toxicology and Applied Pharmacology. 2012, 263: 338-344
Wahl S, Yu Z, Kleber M, Singmann P, Holzapfel C, He Y, Mittelstrass K, Polonikov A, Prehn C, Römisch-Margl W, Adamski J, Suhre K, Grallert H, Illig T, Wang-Sattler R, Reinehr T. Childhood Obesity Is Associated with Changes in the Serum Metabolite Profile. Obes Facts. 2012, 5: 660-670
2011
Von Kries R, Ensenauer R, Beyerlein A, Amann-Gassner U, Hauner H, Schaffrath Rosario A. Gestational weight gain and overweight in children: Results from the cross-sectional German KiGGS study. Int J Pediatr Obes. 2011, 6(1): 45-52
Tiller G, Laumen H, Fischer-Posovsky P, Finck A, Skurk T, Keuper M, Brinkmann U, Wabitsch M, Link D, Hauner H. LIGHT (TNFSF14) inhibits adipose differentiation without affecting adipocyte metabolism. Int J Obes. 2011, 35: 208-216
Holzapfel C, Grallert H, Baumert J, Thorand B, Döring A, Wichmann HE, Hauner H, Illig T, Mielck A. First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study. J Epidemiol Community Health. 2011, 65(2): 174-176
Mueller A, Holzapfel C, Hauner H, Crosby RD, Engel SG, Mühlhans B, Kolotkin RL, Mitchell JE, Horbach T, Zwaan MD. Psychometric Evaluation of the German Version of the Impact of Weight on Quality of Life-Lite (IWQOL-Lite) Questionnaire. Exp Clin Endocrinol Diabetes. 2011, 119(2): 69-74
Krane M, Dummler S, Dreßen M, Hauner H, Hoffmann M, Haller D, Heller K, Wildhirt S, Voss B, Grammer J, Lahm H, Lange R, Bauernschmitt R. Identification of an up-regulated anti-apoptotic network in the internal thoracic artery. Int J Cardiol. 2011, 149: 221-226
Becker S, Schmid D, Amann-Gassner U, Hauner H. Verwendung von Nährstoffsupplementen vor und während der Schwangerschaft. Ernährungsumschau. 2011, 1: 36-41
Holzapfel C, Siegrist M, Rank M, Langhof H, Grallert H, Baumert J, Irimie C, Klopp N, Wolfarth B, Illig T, Hauner H, Halle M. Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS. Eur J End. 2011, 164: 205-212
Köster I, Huppertz E, Hauner H, Schubert I. Direct Costs of Diabetes Mellitus in Germany - CoDiM 2000-2007. Exp Clin Endocrinol Diabetes. 2011, 119(6): 377-385
Claussnitzer M, Skurk T, Hauner H, Daniel H, Rist MJ. Effect of flavonoids on basal and insulin-stimulated 2-deoxyglucose uptake in adipocytes. Mol Nutr Food Res. 2011, 55 Suppl 1: 26-34
Sandgruber S, Much D, Amann-Gassner U, Hauner H, Buettner A. Sensory and molecular characterisation of human milk odour profiles after maternal fish oil supplementation during pregnancy and breastfeeding. Foodchem. 2011, 128(2): 485-494
Jebb SA, Ahern AL, Olson AD, Aston LM, Holzapfel C, Stoll J, Amann-Gassner U, Simpson AE, Fuller NR, Pearson S, Lau NS, Mander AP, Hauner H, Caterson ID. Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial. The Lancet. 2011, 378(9801): 1485-1492
Nehring I, Schmoll S, Beyerlein A, Hauner H, von Kries R. Gestational weight gain and long-term postpartum weight retention: a meta-analysis. Am J Clin Nutr. 2011, 94(5): 1225-1237
Arner P, Bernard S, Salehpour M, Possnert G, Liebl J, Steier P, Buchholz BA, Eriksson M, Arner E, Hauner H, Skurk T, Ryde´n M, Frayn KN, Spalding KL. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature. 2011, 478: 110-113
Dummler S, Eichhorn S, Tesche C, Schreiber U, Voss B, Deutsch MA, Hauner H, Lahm H, Lange R, Krane M. Pulsatile ex vivo perfusion of human saphenous vein grafts under controlled pressure conditions increases MMP-2 expression. Biomed Eng Online. 2011, doi:10.1186/1475-925X-10-62 [Epub]
Cordes J, Thünker J, Regenbrecht G, Zielasek JR, Correll CU, Schmidt-Kraepelin C, Lange-Asschenfeldt C, Agelink MW, Kahl KG, Gaebel W, Klimke A, Hauner H. Can an early weight management program (WMP) prevent olanzapine (OLZ)-induced disturbances in body weight, blood glucose and lipid metabolism? Twenty-four- and 48-week results from a 6-month randomized trial. World J Biol Psychiatry. 2011, doi:10.3109/15622975.2011.592546 [Epub]
Kilpelainen TO, ...Holzapfel C, ...Loos RJF. Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children. PLoS Medicine. 2011, 8(11): e1001116 [Epub]
Martin E, Ruf E, Landgraf R, Hauner H, Weinauer F, Martin S. FINDRISK Questionnaire Combined with HbA1c Testing as a Potential Screening Strategy for Undiagnosed Diabetes in a Healthy Population. Horm Metab Res. 2011, 43(11): 782-787
Laurencikiene J, Skurk T, Kulyté A, Hedén P, Aström G, Sjölin E, Rydén M, Hauner H, Arner P. Regulation of Lipolysis in Small and Large Fat Cells of the Same Subject. J Clin Endocrinol Metab. 2011, 96(12): E2045-E2049
Krinninger P, Brunner C, Ruiz PA, Schneider E, Marx N, Foryst-Ludwig A, Kintscher U, Haller D, Laumen H, Hauner H. Role of the adipocyte-specific NF-κB activity in the regulation of IP-10 and T cell migration. Am J Physiol Endocrinol Metab. 2011, 300(2): E304-11.
2010
Schusdziarra V, Hausmann M, Wittke C, Mittermeier J, Kellner M, Wagenpfeil S, Erdmann J. Contribution of energy density and food quantity to short-term fluctuations of energy intake in normal weight and obese subjects. Eur J Nutr. 2010, 49: 37-43
Schirrmacher G, Skurk T, Hauner H, Graßmann J. Effect of Spinacia oleraceae L. and Perilla frutescens L. on Antioxidants and Lipid Peroxidation in an Intervention Study in Healthy Individuals. Plant Foods Hum Nutr. 2010, 65(1): 71-76
Holzapfel C, Grallert H, Huth C, Wahl S, Fischer B, Döring A, Rückert IM, Hinney A, Hebebrands J, Wichmann HE, Hauner H, Illig T, Heid IM. Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA. Int J Obes. 2010, 34: 1538-1545
Klenke S, Tan S, Hahn S, Mann K, Hauner H, Manthey I, Peters J, Siffert W, Frey UH. A functional GNAQ promoter haplotype is associated with altered Gq expression and with insulin resistance and obesity in women with polycystic ovary syndrome. Pharmacogenet Genomics. 2010, 20(8): 476-84
Pendergast K, Wolf A, Sherrill B, Zhou X, Aronne LJ, Caterson I, Finer N, Hauner H, Hill J, Van Gaal L, Coste F, Despres JP. Impact of waist circumference difference on health-care cost among overweight and obese subjects: the PROCEED cohort. Value Health. 2010, 13(4): 402-10
Lang R, Wahl A, Skurk T, Yagar EF, Schmiech L, Eggers R, Hauner H, Hofmann T. Development of a hydrophilic liquid interaction chromatography-high-performance liquid chromatography-tandem mass spectrometry based stable isotope dilution analysis and pharmacokinetic studies on bioactive pyridines in human plasma and urine after coffee consumption. Anal Chem. 2010, 15;82(4): 1486-97
2009
Skurk T, Alberti-Huber C, Hauner H. Effect of Conditioned Media from Mature Human Adipocytes on Insulin-stimulated Akt/PKB Phosphorylation in Human Skeletal Muscle Cells: Role of BMI and Fat Cell Size. Horm Metab Res. 2009, 41(3): 190-196
Amann K, Haas CS, Zeiler GA, Benz K, Bader BL, Hartner A, Hilgers KF. Lack of nidogen-2 increases blood pressure, glomerular and tubulointerstitial damage in DOCA-salt hypertension. Eur J Clin Invest. 2009, 39(2): 116-25
Mack I, BelAiba RS, Djordjevic T, Görlach A, Hauner H, Bader BL. Human preadipocytes under normoxia, hypoxia and TNF-alpha exposure are activators of human microvascular endothelial cells in co-culture – a situation different for normoxic adipocytes. Am J Physiol Endoc Metab. 2009, 297: E735-E748
Laumen H, Saningong AD, Heid IM, Hess J, Herder C, Claussnitzer M, Baumert J, Lamina C, Rathmann W, Sedlmaier EM, Klopp N, Thorand B, Wichmann HE, Illig T, Hauner H. Functional characterization of promotor variants of the adiponectin gene complemented by epidemiological data. Diab. 2009, 68: 984-991
Singmann P, Baumert J, Herder C, Meisinger C, Holzapfel C, Klopp N, Wichmann HE, Klingenspor M, Rathmann W, The KORA group, Illig T, Grallert H. Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome. Obes Facts. 2009, 2(4): 235-242
Erdmann J, Mayr M, Oppel U, Sypchenko O, Wagenpfeil S, Schusdziarra V. Weight-dependent differential contribution of insulin secretion and clearance to hyperinsulinemia of obesity. Reg Peptides. 2009, 152: 1-7
Schusdziarra V, Sassen M, Hausmann M, Barth C, Erdmann J. Lebensmittelverzehr Übergewichtiger und Adipöser. Akt Ernähr Med. 2009, 1: 19-26
Schusdziarra V, Sassen M, Hausmann M, Wittke C, Erdmann J. Lebensmittelverzehr sowie Energieaufnahme, Essensmenge und Energiedichte bei Haupt- und Zwischenmahlzeiten Übergewichtiger und Adipöser. Akt Ernähr Med. 2009, 1: 186-194
Schusdziarra V, Sassen M, Hausmann M, Erdmann J. Veränderungen des Lebensmittelverzehrs während der Tag-zu-Tag-Schwankungen der Energieaufnahme bei Adipösen. Akt Ernähr Med. 2009, 1: 278-284
Kurjak M, Hanel AM, Allescher HD, Schusdziarra V, Storr M. Differential stimulatory effects of endocannabinoids on VIP release and NO synthase activity in synaptosomal fractions from rat ileum. Neuropeptides. 2009, 42(5-6): 623-32
Schnäbele K, Roser S, Rechkemmer G, Hauner H, Skurk T. Effects of adipocyte-secreted factors on cell cycle progression in HT29 cells. Eur J Nutr. 2009, 48: 154-161
Skurk T, Mack I, Kempf K, Kolb H, Hauner H, Herder C. Expression and Secretion of RANTES (CCL5) in Human Adipocytes in Response to Immunological Stimuli and Hypoxia.Horm Metab Res. 2009, 41: 183-189
Hauner H, Vollhardt C, Schneider KTM, Zimmermann A, Schuster T, Amann-Gassner U. The impact of nutritional fatty acids during pregnancy and lactation on early human adipose tissue development: rationale and design of the INFAT study. Ann Nutr Metab. 2009, 54: 97-103
Frank H, Graf J, Amann-Gassner U, Bratke R, Daniel H, Heemann U, Hauner H. Effect of short-term high-protein compared with normal-protein diets on renal hemodynamics and associated variables in healthy young men. Am J Clin Nutr. 2009, 90: 1509-16
Hauner H, Kohlmann T, Landgraf W, Holle R, Pirk O, Scholten T. Costs of antihyperglycemic drugs and consumables and treatment satisfaction in patients with type 2 diabetes. Results of the health care research study LIVE-DE (long-acting insulin glargine compared with NPH insulin in Germany). Dtsch Med Wochenschr. 2009, 134: 1207-13
Schnappinger M, Sausenthaler S, Linseisen J, Hauner H, Heinrich J. Fish consumption, allergic sensitisation and allergic diseases in adults. Ann Nutr Metab. 2009, 54: 67-74
Skurk T, Alberti-Huber C, Hauner H. Effect of conditioned media from mature human adipocytes on insulin-stimulated Akt/PKB phosphorylation in human skeletal muscle cells: role of BMI and fat cell size. Horm Metab Res. 2009, 41: 190-6
Bauer JM, Haack A, Winning K, Wirth R, Fischer B, Uter W, Erdmann J, Schusdziarra V, Sieber CC. Impaired Postprandial Response of Active Ghrelin and Prolonged Suppression of Hunger Sensation in the Elderly. J Gerontol A Biol Sci Med Sci. 2009, 65A(3): 307-311
Tiller G, Fischer-Posovszky P, Laumen H, Finck A, Skurk T, Keuper M, Brinkmann U, Wabitsch M, Link D, Hauner H. Effects of TWEAK (TNF Superfamily Member 12) on Differentiation, Metabolism, and Secretory Function of Human Primary Preadipocytes and Adipocytes. Endocrinology. 2009, 150: 5373-83
2008
Knoll KP, Hauner H. Kosten der Adipositas in der Bundesrepublik Deutschland – eine aktuelle Krankheitskostenstudie. Adipositas. 2008, 2: 204-210
Steinhagen-Thiessen E, Bramlage P, Losch C, Hauner H, Schunkert H, Vogt A, Wasem J, Jockel KH, Moebus S. Dyslipidemia in primary care - prevalence, recognition, treatment and control: data from the German Metabolic and Cardiovascular Risk Project (GEMCAS). Cardiovasc Diabetol. 2008, 7: 31-41
Holzapfel C, Baumert J, Grallert H, Müller AM, Thorand B, Khuseyinova N, Herder C, Meisinger C, Hauner H, Wichmann HE, Koenig W, Illig T, Klopp N. Genetic variants in the upstream regulatory factor 1 (USF1) gene are associated with low-density lipoprotein cholesterol levels and incident type 2 diabetes mellitus in women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Eur J Endocrinol. 2008, 159: 407-416
Kuhn K, Knoll A, Mewes HW, Schwaiger M, Bode A, Broy A, Daniel H, Feussner H, Gradinger R, Hauner H, Höfler H, Holzmann B, Horsch A, Kemper A, Krcmar H, Kochs EF, Lange R, Leidl R, Mansmann U, Mayr EW, Meitinger T, Molls M, Navab N, Nüsslin F, Peschel C, Reiser M, Ring J, Rummeny EJ, Schlichter J, Schmid R, Wichmann HE, Ziegl S. From Molecules to Populations. Methods Inf Med. 2008, 47: 283–295
Laumen H, Skurk T, Hauner H. The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes. Atherosclerosis. 2008, 196: 565-573
Wolf AM, Finer N, Pendergast KB, Sherrill BH, Caterson I, Hill JO, Aronne LJ, Hauner H, Radigue C, Amand C, Despres JP. PROCEED: Prospective Obesity Cohort of Economic Evaluation and Determinants: baseline health and healthcare utilization of the US sample. Diab Obes Metab. 2008, 10: 1248-1260
Moebus S, Hanisch JU, Lösch C, Bramlage P, Schunkert H, Hauner H, Wasem J, Jöckel KH. Erhöhter Blutdruck und abdominale Adipositas sind die häufigsten Faktoren des metabolischen Syndroms in einer Kohorte von 35.869 Patienten in der primär-ärztlichen Versorgung. J Hyperton. 2008, 12: 7-11
Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, Wabitsch M, Fischer-Posovszky P, Barth TFE, Dragun D, Skurk T, Hauner H, Blüher M, Unger T, Wolf AM, Knippschild U, Hombach V, Marx N. T-lymphocyte Infiltration in Visceral Adipose Tissue. A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance. Arterioscler Thromb Vasc Biol. 2008, 28: 1304-1310
Frey U, Hauner H, Jöckel KH, Manthey I, Brockmeyer N, Siffert W. A novel promoter polymorphism in the human gene GNAS affects binding of transcription factor upstream stimulatory factor 1, Gas protein expression and body weight regulation. Pharmacogenet Genomics. 2008, 18: 141-151
Moebus S, Hanisch J, Bramlage P, Lösch C, Hauner H, Wasem J, Jöckel KH. Regional unterschiedliche Prävalenz des metabolischen Syndroms in Deutschland. Dtsch Ärztebl. 2008, 12: 207-214
Schusdziarra V, Zimmermann JP, Erdmann J, Bader U, Schick RR. Differential inhibition of galanin – and ghrelin – induced food intake by i.c.v. GLP-1 (7-36)- amide. Regul Pept. 2008, 147: 29-32
Erdmann J, Kallabis B, Oppel U, Sypchenko O, Wagenpfeil S, Schusdziarra V. Development of hyperinsulinemia and insulin resistance during the early stage of weight gain. Am J Physiol Endocrinol Metab. 2008, 294: E568-E575
Hauner H, Hanisch J, Bramlage P, Steinhagen-Thiessen E, Schunkert H, Jöckel KH, Wasem J, Moebus S. Prevalence of undiagnosed type 2 diabetes mellitus and impaired fasting glucose in German primary care: data from the German Metabolic and Cardiovascular Risk Project (GEMCAS). Exp Clin Endocrinol & Diabetes. 2008, 116: 18-25
Hauner H, Bramlage P, Lösch C, Steinhagen-Thiessen E, Schunkert H, Wasem J, Joeckel KH, Moebus S. Prevalence of obesity in primary care using different anthropometric measures – Results of the German Metabolic and Cardiovascular Risk Study (GEMCAS).BMC Public Health. 2008, 8: 282
Müller N, Schiel R, Osterbrink B, Holl RW, Kerner W, Hauner H, Beyer P, Hoyer H, Krug J, Müller UA. Behandlungsqualität von Patienten mit Diabetes mellitus Typ 1 und Typ 2 in Schwerpunktpraxis, Diabetesfachklinik und Akutkrankenhaus in der Bundesrepublik Deutschland 2005. Auswertung der Zertifizierungsdaten zur Diabeteseinrichtung DDG. Diabetol Stoffw. 2008, 3: 41-50
Schunkert H, Moebus S, Hanisch J, Bramlage P, Steinhagen-Thiessen E, Hauner H, Weil J, Wasem J, Jöckel KH. The correlation between waist circumference and ESC Cardiovascular Risk Score: data from the German Metabolic and Cardiovascular Risk Project (GEMCAS). Clin Res Cardiol. 2008, November 2008, 97: 827-835
Hauner H, Bramlage P, Lösch C, Schunkert H, Wasem J, Joeckel KH. Übergewicht, Adipositas und erhöhter Taillenumfang. Regionale Prävalenzunterschiede in der hausärztlichen Versorgung. Dtsch Ärztebl. 2008, 105: 827-833
Lippl F, Erdmann J, Lichter N, Tholl S, Wagenpfeil S, Adam O, Schusdziarra V. Relation of plasma obestatin levels to BMI, gender, age and insulin. Horm Metab Res. 2008, 40: 806-812
Kurjak M, Hamel AM, Allescher HD, Schusdziarra V, Storr M. Differential stimulatory effects of cannabinoids on VIP release and NO synthase activity in synaptosomal fractions from rat ileum. Neuropeptides. 2008, 42: 623-632
Holzapfel C, Gedrich K, Karg G, Lang O, Döring A. Selbsteinschätzung des Gesundheitszustands und Body Mass Index Ergebnisse aus dem MONICA/KORA-Projekt Augsburg. Ernährungs Umschau. 2008, 55: 584-591
Lämmermann T, Bader BL, Monkley SJ, Worbs T, Wedlich-Söldner R, Hirsch K, Keller M, Förster R, Critchley DR, Fässler R, Sixt M. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature. 2008, 453: 51-55
2007
Kaline K, Bernstein SR, Bergmann A, Hauner H, Schwarz PEH. The importance and effect of dietary fiber in diabetes prevention with particular consideration of whole grain products. Horm Metab Res. 2007, 39:687-693
Laumen H, Skurk T, Hauner H. The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes. Atherosclerosis. 2007, 196(2): 565-73
Rathmann W, Haastert B, Herder C, Hauner H, Koenig W, Meisinger C, Holle R, Giani G. Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA Survey 2004. Int J Obes Relat Metab Disord. 2007, 28: 770-776
Lee Y, Skurk T, Hennig M, Hauner H. Effect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertension. Eur J Nutr. 2007, 46: 21-27
Skurk T, Alberti-Huber C, Herder C, Hauner H. Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab. 2007, 92: 1023-1033
Dicker A, Aström G, Sjölin E, Hauner H, Arner P, van Harmelen V. The influence of preadipocyte differentiation capacity on lipolysis in human mature adipocytes. Horm Metab Res. 2007, 39: 377-385
Skurk T, Ecklebe S, Hauner H. A Novel Technique to Propagate Primary Human Preadipocytes without Loss of Differentiation Capacity. Obes. 2007, 15: 2925–2931
Hauner H, Köster I, Schubert I. Trends in der Prävalenz und ambulanten Versorgung von Menschen mit Diabetes mellitus. Deutsches Ärzteblatt. 2007, 41: A2799-2805
Hauner H, Hanisch J, Bramlage P, Steinhagen-Thiessen E, Schunkert H, Jöckel KH, Wasem J, Moebus S. Prevalence of Undiagnosed Type-2-Diabetes Mellitus and Impaired Fasting Glucose in German Primary Care: Data from the German Metabolic and Cardiovascular Risk Project (GEMCAS). Exp Clin Endocrinol Diab. 2007, 116: 18-25
Stein E, Marais D, Ducobu J, Farnier M, Gavish D, Hauner H, Kaplan AJ, Le Maulf F, Melezínková H. Comparison of short-term renal effects and efficacy of rosuvastatin 40 mg and simvastatin 80 mg, followed by assessment of long-term renal effects of rosuvastatin 40 mg, in patients with dyslipidemia. J Clin Lip. 2007, 1: 287-299
Holzapfel C, Klopp N, Grallert H, Huth C, Gieger C, Meisinger C, Strassburger K, Giani G, Wichmann HE, Laumen H, Hauner H, Herder C, Rathmann W, Illig T. Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study). Eur J Endocrinol. 2007, 157: R1–R5
Herder C, Hauner H, Kempf K, Kolb H, Skurk T. Constitutive and regulated expression and secretion of interferon-γ-inducible protein 10 (IP-10/CXCL 10) in human adipocytes. Int J Obes. 2007, 31: 403-410
Schulte-Frohlinde E, Wagenpfeil S, Willis J, Lersch C, Eckel F, Schmid R, Schusdziarra V. Role of meal carbohydrate content for the imbalance of plasma amino acids in patients with liver cirrhosis. J Gastr Hep. 2007, 22: 1241-1248
Erdmann J, Tahbaz R, Lippl F, Wagenpfeil St, Schusdziarra V. Plasma ghrelin levels during exercise – effects of intensity and duration. Reg Peptides. 2007, 143: 127-135
Erdmann J, Hebeisen Y, Lippl F, Wagenpfeil St, Schusdziarra V. Food intake and plasma ghrelin response during potato-, rice- and pasta-rich test meals. Eur J Nutr. 2007, 46: 196-203
Bauer JM, Wirth R, Troegner J, Erdmann J, Eberl T, Heppner HJ, Schusdziarra V, Sieber CC. Ghrelin, anthropometry and nutritional assessment in geriatric ospital patients. Z Gerontol Geriat. 2007, 40: 31-36
Schusdziarra V, Zimmermann JP, Erdmann J, Bader U, Schick RR. Differential inhibition of galanin – and ghrelin – induced food intake by i.c.v. GLP-1 (7-36)-amide. Reg Peptides. 2007, 147: 29-32
Erdmann J, Kallabis B, Oppel U, Sypchenko O, Wagenpfeil S, Schusdziarra V. Development of hyperinsulinemia and insulin resistance during the early stage of weight gain. Am J Physiol. 2007, 294: E568-E575
Von Ferber L, Köster I, Hauner H. Medical Costs of Diabetic Complications Total Costs and Excess Costs by Age and Type of Treatment Results of the German CoDiM Study. Exp Clin Endocrinol & Diab. 2007, 115: 97-104
Sedlmeier E, Grallert H, Huth C, Löwel H, Herder C, Strassburger K, Giani G, Wichmann H, Hauner H, Illig T, Rathmann W. Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg. Euro J Endocrinol. 2007, 156: 1-10
Frey UH, Hauner H, Jöckel KH, Manthey I, Brockmeyer N, Siffert W. A novel promotor polymorphism in the human gene GNAS affects binding of transcription factor USF-1, Gαs protein expression and body weight regulation. Pharmacogenetics and Genomics. 2007, 18: 141-151
Moebus S, Hanisch J, Bramlage P, Lösch C, Hauner H, Wasem J, Jöckel KH. Regionale Unterschiede in der Prävalenz des metabolischen Syndroms in Deutschland. Dt Ärztebl. 2007, 105(12): A207-213
Molekulare Ernährungsmedizin
2022
Baur, S., Bellé, N., Frank, O., Wurzer, S., Pieczonka, S.A., Fromme, T., Stam, R., Hausladen, H., Hofmann, T., Hückelhoven, R., Dawid, C., 2022. Steroidal Saponins─New Sources to Develop Potato (Solanum tuberosum L.) Genotypes Resistant against Certain Phytophthora infestans Strains. J Agric Food Chem 70, 7447–7459. doi.org/10.1021/acs.jafc.2c02575
Borchard, S., Raschke, S., Zak, K.M., Eberhagen, C., Einer, C., Weber, E., Müller, S.M., Michalke, B., Lichtmannegger, J., Wieser, A., Rieder, T., Popowicz, G.M., Adamski, J., Klingenspor, M., Coles, A.H., Viana, R., Vendelbo, M.H., Sandahl, T.D., Schwerdtle, T., Plitz, T., Zischka, H., 2022. Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage. Life Sci Alliance 5, e202101164. doi.org/10.26508/lsa.202101164
Bruder, J., Fromme, T., 2022. Global Adipose Tissue Remodeling During the First Month of Postnatal Life in Mice. Front Endocrinol (Lausanne) 13, 849877. doi.org/10.3389/fendo.2022.849877
Copperi, F., Schleis, I., Roumain, M., Muccioli, G.G., Casola, S., Klingenspor, M., Pfeifer, A., Gnad, T., 2022. EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes. Commun Biol 5, 280. doi.org/10.1038/s42003-022-03201-6
Dieckmann, S., Strohmeyer, A., Willershäuser, M., Maurer, S.F., Wurst, W., Marschall, S., de Angelis, M.H., Kühn, R., Worthmann, A., Fuh, M.M., Heeren, J., Köhler, N., Pauling, J.K., Klingenspor, M., 2022. Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1. Am J Physiol Endocrinol Metab 322, E85–E100. doi.org/10.1152/ajpendo.00278.2021
Laurila, S., Rebelos, E., Lahesmaa, M., Sun, L., Schnabl, K., Peltomaa, T.-M., Klén, R., U-Din, M., Honka, M.-J., Eskola, O., Kirjavainen, A.K., Nummenmaa, L., Klingenspor, M., Virtanen, K.A., Nuutila, P., 2022. Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function. Am J Physiol Endocrinol Metab 322, E54–E62. doi.org/10.1152/ajpendo.00260.2021
Li, Y., Fromme, T., 2022. Uncoupling Protein 1 Does Not Produce Heat without Activation. Int J Mol Sci 23, 2406. doi.org/10.3390/ijms23052406
Li, Y., Li, Z., Ngandiri, D.A., Llerins Perez, M., Wolf, A., Wang, Y., 2022. The Molecular Brakes of Adipose Tissue Lipolysis. Front Physiol 13, 826314. doi.org/10.3389/fphys.2022.826314
Nezhad, F.Y., Riermeier, A., Schönfelder, M., Becker, L., de Angelis, M.H., Wackerhage, H., 2022. Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers. Transgenic Res 31, 227–237. doi.org/10.1007/s11248-021-00293-4
Oeckl, J., Janovska, P., Adamcova, K., Bardova, K., Brunner, S., Dieckmann, S., Ecker, J., Fromme, T., Funda, J., Gantert, T., Giansanti, P., Hidrobo, M.S., Kuda, O., Kuster, B., Li, Y., Pohl, R., Schmitt, S., Schweizer, S., Zischka, H., Zouhar, P., Kopecky, J., Klingenspor, M., 2022. Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat. Mol Metab 61, 101499. doi.org/10.1016/j.molmet.2022.101499
Wang, J., Onogi, Y., Krueger, M., Oeckl, J., Karlina, R., Singh, I., Hauck, S.M., Feederle, R., Li, Y., Ussar, S., 2022. PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes. Mol Metab 61, 101508. doi.org/10.1016/j.molmet.2022.101508
Xie, K., Fuchs, H., Scifo, E., Liu, D., Aziz, A., Aguilar-Pimentel, J.A., Amarie, O.V., Becker, L., da Silva-Buttkus, P., Calzada-Wack, J., Cho, Y.-L., Deng, Y., Edwards, A.C., Garrett, L., Georgopoulou, C., Gerlini, R., Hölter, S.M., Klein-Rodewald, T., Kramer, M., Leuchtenberger, S., Lountzi, D., Mayer-Kuckuk, P., Nover, L.L., Oestereicher, M.A., Overkott, C., Pearson, B.L., Rathkolb, B., Rozman, J., Russ, J., Schaaf, K., Spielmann, N., Sanz-Moreno, A., Stoeger, C., Treise, I., Bano, D., Busch, D.H., Graw, J., Klingenspor, M., Klopstock, T., Mock, B.A., Salomoni, P., Schmidt-Weber, C., Weiergräber, M., Wolf, E., Wurst, W., Gailus-Durner, V., Breteler, M.M.B., Hrabě de Angelis, M., Ehninger, D., 2022. Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice. Nat Commun 13, 6830. doi.org/10.1038/s41467-022-34515-y
2021
Müller TD, Klingenspor M, Tschöp MH. Revisiting energy expenditure: how to correct mouse metabolic rate for body mass. Nat Metab. 2021 Sep 6. doi: 10.1038/s42255-021-00451-2. Epub ahead of print. PMID: 34489606.
Dieckman S, Maurer S, Kleigrewe K, Klingenspor M. Spatial Recruitment of Cardiolipins in Inguinal White Adipose Tissue after Cold Stimulation is Independent of UCP1. European Journal of Lipid Science and Technology. Sep. 2021. Wiley Online Library. doi.org/10.1002/ejlt.202100090
Trujillo‐Viera J, El‐Merahbi R, Schmidt V, Karwen T, Loza‐Valdes A, Strohmeyer A, Reuter S, Noh M, Wit M, Hawro I, Mocek S, Fey C, Mayer AE, Löffler MC, Wilhelmi I, Metzger M, Ishikawa E, Yamasaki S, Rau M, Geier A, Hankir M, Seyfried F, Klingenspor M, Sumara G. Protein Kinase D2 drives chylomicron‐mediated lipid transport in the intestine and promotes obesity. EMBO Molecular Medicine. 2021.13:5. doi:10.15252/emmm.202013548.
Schnabl K, Li Y, U-Din M, Klingenspor M. Secretin as a satiation whisperer with the potential to turn into an obesity-curbing knight. Endocrinology. 2021 Jun 5:bqab113. doi: 10.1210/endocr/bqab113. Epub ahead of print. PMID: 34089599.
Bast-Habersbrunner A, Kiefer C, Weber P, Fromme T, Schießl A, Schwalie PC, Deplancke B, Li Y, Klingenspor M. LncRNA Ctcflos orchestrates transcription and alternative splicing in thermogenic adipogenesis. EMBO Rep. 2021 May 31:e51289. doi: 10.15252/embr.202051289. Epub ahead of print. PMID: 34056831.
Trujillo-Viera J, El-Merahbi R, Schmidt V, Karwen T, Loza-Valdes A, Strohmeyer A, Reuter S, Noh M, Wit M, Hawro I, Mocek S, Fey C, Mayer AE, Löffler MC, Wilhelmi I, Metzger M, Ishikawa E, Yamasaki S, Rau M, Geier A, Hankir M, Seyfried F, Klingenspor M, Sumara G. Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity. EMBO Mol Med. 2021 May 7;13(5):e13548. doi: 10.15252/emmm.202013548. Epub 2021 May 5. PMID: 33949105; PMCID: PMC8103097.
Gantert T, Henkel F, Wurmser C, Oeckl J, Fischer L, Haid M, Adamski J, Esser-von Bieren J, Klingenspor M, Fromme T. Fibroblast growth factor induced Ucp1 expression in preadipocytes requires PGE2 biosynthesis and glycolytic flux. FASEB J. 2021 May;35(5):e21572. doi: 10.1096/fj.202002795R. PMID: 33826782.
Novikoff A, O’Brien SL, Bernecker M, Grandl G, Kleinert M, Knerr PJ, Stemmer K, Klingenspor M, Zeigerer A, DiMarchi R, Tschöp MH, Finan B, Calebiro D, Müller DT. Spatiotemporal GLP-1 and GIPR receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists. Molecular Metabolism. 2021. ISSN 2212-8778. doi.org/10.1016/j.molmet.2021.101181.
Fasoula NA, Karlas A, Kallmayer M, Milik AB, Pelisek J, Eckstein HH, Klingenspor M, Ntziachristos V. Multicompartmental non-invasive sensing of postprandial lipemia in humans with multispectral optoacoustic tomography. Mol Metab. 2021 Feb 5;47:101184. doi: 10.1016/j.molmet.2021.101184. Epub ahead of print. PMID: 33549846; PMCID: PMC7918675.
2020
Oeckl J, Bast-Habersbrunner A, Fromme T, Klingenspor M, Li Y. Isolation, Culture, and Functional Analysis of Murine Thermogenic Adipocytes. STAR Protoc. 2020 Sep 22;1(3):100118. doi: 10.1016/j.xpro.2020.100118. PMID: 33377014; PMCID: 7757011.
Maurer SF, Dieckmann S, Lund J, Fromme T, Hess AL, Colson C, Kjølbaek L, Astrup A, Gillum MP, Larsen LH, Liebisch G, Amri EZ, Klingenspor M. No Effect of Dietary Fish Oil Supplemen-tation on the Recruitment of Brown and Brite Adipocytes in Mice or Humans under Ther-moneutral Conditions. Mol Nutr Food Res. 2020 Dec 4: e2000681. doi: 10.1002/mnfr.202000681. Epub ahead of print. PMID: 33274552.
Wang H, Willershäuser M, Li Y, Fromme T, Schnabl K, Bast-Habersbrunner A,Ramisch S, Mocek S, Klingenspor M. Uncoupling protein 1 expression does not protect mice from diet-induced obesity. Am J Physiol Endocrinol Metab. 2020 Nov 30. doi: 10.1152/ajpendo.00285.2020. Epub ahead of print. PMID: 33252252.
Brandl B, Skurk T, Rennekamp R, Hannink A, Kiesswetter E, Freiherr J, Ihsen S, Roosen J, Klingenspor M, Haller D, Krautwurst D, Hofmann T, Linseisen J,Volkert D, Hauner H. A Phe-notyping Platform to Characterize Healthy Individuals Across Four Stages of Life - The “Ena-ble”- Study. Front Nutr. 2020 Oct 28; 7:582387. doi: 10.3389/fnut.2020.582387. PMID: 33195372; PMCID: PMC7657309.
Riba A, Hassani K, Walker A, van Best N, von Zeschwitz D, Anslinger T, Sillner N, Rosenhain S, Eibach D, Maiga-Ascofaré O, Rolle-Kampczyk U, Basic M, Binz A, Mocek S, Sodeik B, Bauer-feind R, Mohs A, Trautwein C, Kiessling F, May J, Klingenspor M, Gremse F, Schmitt-Kopplin P, Bleich A, Torow N, von Bergen M, Hornef MW. Disturbed gut microbiota and bile homeo-stasis in “Giardia”-infected mice contributes to metabolic dysregulation and growth im-pairment. Sci Transl Med. 2020 Oct 14;12(565): eaay7019. doi: 10.1126/scitranslmed.aay7019. PMID: 33055245.
Kollmann P, Elfers K, Maurer S, Klingenspor M, Schemann M, Mazzuoli-Weber G. Submucosal enteric neurons of the cavine distal colon are sensitive to hypoosmolar stimuli [published online ahead of print, 2020 Sep 3]. J Physiol. 2020;10.1113/JP280309. doi:10.1113/JP280309. pubmed
Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perrochi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Krönke M, Zehn D, Protzer U, Heikenwälder M, Knolle PA, Wohlleber D. Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.J Hepatol. 2020 Jun 26:S0168-8278(20)30398-6. doi: 10.1016/j.jhep.2020.06.026. Online ahead of print. pubmed
Fischer K, Fenzl A, Liu D, Dyar KA, Kleinert M, Brielmeier M, Clemmensen C, Fedl A, Finan B, Gessner A, Jastroch M, Huang J, Keipert S, Klingenspor M, Brüning JC, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Sachs S, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Woods SC, Zorn J, Stemmer K, Collins S, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD. The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nat Commun. 2020 May 8;11(1):2306. doi: 10.1038/s41467-020-16230-8. pubmed
Jarzab A, Kurzawa N, Hopf T, Moerch M, Zecha J, Leijten N, Bian Y, Musiol E, Maschberger M, Stoehr G, Becher I, Daly C, Samaras P, Mergner J, Spanier B, Angelov A, Werner T, Bantscheff M, Wilhelm M, Klingenspor M, Lemeer S, Liebl W, Hahne H, Savitski MM, Kuster B. Meltome atlas-thermal proteome stability across the tree of life. Nat Methods. 2020;17(5):495-503. doi:10.1038/s41592-020-0801-4. pubmed
Schnabl K, Li Y, Klingenspor M: The gut hormone secretin triggers a gut-brown fat-brain axis in the control of food intake. Exp Physiol. 2020 Apr 9. doi: 10.1113/EP087878. [Epub ahead of print]. pubmed
Schöttl T, Pachl F, Giesbertz P, Daniel H, Kuster B, Fromme T, Klingenspor M: Proteomic and Metabolite Profiling Reveals Profound Structural and Metabolic Reorganization of Adipocyte Mitochondria in Obesity.Obesity (Silver Spring). 2020 Mar;28(3):590-600. doi: 10.1002/oby.22737. Epub 2020 Feb 7. pubmed
Dieckmann S, Maurer S, Fromme T, Colson C, Virtanen KA, Amri EZ, Klingenspor M: Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue.Front Endocrinol (Lausanne). 2020 Feb 21;11:73. doi: 10.3389/fendo.2020.00073. eCollection 2020. pubmed
Maurer SF, Fromme T, Mocek S, Zimmermann A, Klingenspor M: Uncoupling protein 1 and the capacity for nonshivering thermogenesis are components of the glucose homeostatic system.Am J Physiol Endocrinol Metab. 2020 Feb 1;318(2):E198-E215. doi: 10.1152/ajpendo.00121.2019. Epub 2019 Nov 12. pubmed
2019
Li Y, Schwalie PC, Bast-Habersbrunner A, Mocek S, Russeil J,Fromme T, Deplancke B, Klingenspor M: Systems genetics-based inference of 1 a core regulatory network underlying white fat browning. Cell-Reports. 2019, Vol. 29:4099–4113. cell-reports
Segal J, Mülleder M, Krüger A, Adler T, Scholze-Wittler M, Becker L, Calzada-Wack J, Garrett L, Hölter SM, Rathkolb B, Rozman J, Racz I, Fischer R, Busch DH, Neff F, Klingenspor M, Klopstock T, Grüning NM, Michel S, Lukaszewska-McGreal B, Voigt I, Hartmann L, Timmermann B, Lehrach H, Wolf E, Wurst W, Gailus-Durner V, Fuchs H, H de Angelis M, Schrewe H, Yuneva M, Ralser M. Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency. In: Journal of Inherited Metabolic Disease 2019, 10.1002/jimd.12105. pubmed
Klingenspor M. Secretin Links Brown Fat to Food Intake: New Perspectives for Targeting Energy Balance in Humans. In: Obesity (27) 2019, 10.1002/oby.22477. pubmed
Vetrivel S, Tiso N, Kügler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Götz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Hölter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Rácz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Östereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Graw J. Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia. In: Experimental Eye Research 2019, 10.1016/j.exer.2019.03.024. pubmed
Westphal S, Gantert T, Kless C, Hüttinger K, Klingenspor M, Fromme T. Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes. In: Scientific Reports (9) 2019, 10.1038/s41598-019-44878-w. pubmed
Münch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, Sahm V, Wiethaler M, Baumeister T, Wein F, Einwächter H, Bolze F, Klingenspor M, Haller D, Kavanagh M, Lysaght J, Friedman R, Dannenberg AJ, Pollak M, Holt PR, Muthupalani S, Fox JG, Whary MT, Lee Y, Ren TY, Elliot R, Fitzgerald R, Steiger K, Schmid RM, Wang TC, Quante M. High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett’s Esophagus via Interleukin 8 and Alterations to the Gut Microbiome. In: Gastroenterology (157) 2019, 10.1053/j.gastro.2019.04.013. pubmed
Schweizer S, Liebisch G, Oeckl J, Hoering M, Seeliger C, Schiebel C, Klingenspor M, Ecker J. The lipidome of primary murine white, brite, and brown adipocytes—Impact of beta-adrenergic stimulation. In: PLOS Biology (17) 2019, 10.1371/journal.pbio.3000412. pubmed
Mengue N’dille GPR, Biyiti LF, Fromme T, Essame Oyono JL, Klingenspor M. Ethanolic extract of Iwong (Ipomoea alba L., Convolvulaceae) attenuates Adipogenesis in 3T3-L1 adipocytes. In: International Journal of Herbal Medicine (7) 2019, dx.doi.org/10.22271/flora. Journal of Herbal Medicine
Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T. Adipose Mitochondrial Respiratory Capacity in Obesity is Impaired Independently of Glycemic Status of Tissue Donors. In: Obesity 2019, 10.1002/oby.22435. pubmed
Fromme T, Hüttinger K, Maurer S, Li Y, Gantert T, Fiamoncini J, Daniel H, Westphal S, Klingenspor M: Bile acid supplementation decreases body mass gain in C57BL/6J but not 129S6/SvEvTac mice without increasing energy expenditure. Scientific Reports. volume 9. Article nr. 131, 2019. pubmed
Schnabl K, Westermeier J,Li Y, Klingenspor M: Opposing Actions of Adrenocorticotropic Hormone and Glucocorticoids on UCP1-Mediated Respiration in Brown Adipocytes. Frontieres in physiology.Volume 9. Article 1931.January 17.doi: 10.3389/fphys.2018.019313, 2019. pubmed
Pfeifer A, Klingenspor M, Herzig S: Handbook of Experimental Pharmacology. Springer-Verlag. Vol. 251. 1.st edition. 2019
Kongressbeiträge und sonstiges | MEM | 2019
Schnabl K, Klingenspor M: Brown Fat Starts Heating and Terminates Eating. GIT Laboratory Journal Europe. 2019, p.12-14
Schnabl K, Klingenspor M: Braunes Fett heizt ein und macht satt. GIT Laborportal. 18.03.2019, lesen
2018
Wang H, Willershäuser M, Karlas A, Gorpas D, Reber J, Ntziachristos V, Maurer S, Fromme T, Li Y, Klingenspor M
A dual Ucp1 reporter mouse model for imaging and quantitation of brown and brite fat recruitment. Molecular Metabolism. November 2018 doi: 10.1016/j.molmet.2018.11.009, 2018 Pubmed
Li Y, Schnabl K, Gabler SM, Willershäuser M, Reber J, Karlas A, Laurila S, Lahesmaa M, U Din M, Bast-Habersbrunner A, Virtanen KA, Fromme T, Bolze F, O'Farrell LS, Alsina-Fernandez J, Coskun T, Ntziachristos V, Nuutila P, Klingenspor M
Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation. Cell. Nov 29;175(6):1561-1574.e12. doi: 10.1016/j.cell.2018.10.016. Epub 2018 Nov 15, 2018 Pubmed
Schweizer S, Oeckl J, Klingenspor M, Fromme T. Substrate fluxes in brown adipocytes upon adrenergic stimulation and uncoupling protein 1 ablation. Life Sci Alliance. 2018 Nov 14;1(6):e201800136. doi: 10.26508/lsa.201800136. eCollection 2018 Dec Pubmed
Maurer SF, Dieckmann S, Kleigrewe K, Colson C, Amri EZ, Klingenspor M.
Fatty Acid Metabolites as Novel Regulators of Non-shivering Thermogenesis. Handb Exp Pharmacol.Aug 24. doi: 10.1007/164_2018_150. [Epub ahead of print], 2018 Pubmed
Hankir MK, Klingenspor M.
Brown adipocyte glucose metabolism: a heated subject
EMBO Rep.Sep;19(9). pii: e46404. doi: 10.15252/embr.201846404. Epub 2018 Aug 22. Review, 2018 Pubmed
Nikolakopoulou P, Chatzigeorgiou A, Kourtzelis I, Toutouna L, Masjkur J, Arps-Forker C, Poser SW, Rozman J, Rathkolb B, Aguilar-Pimentel JA; German Mouse Clinic Consortium, Wolf E, Klingenspor M, Ollert M, Schmidt-Weber C, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Tsata V, Monasor LS, Troullinaki M, Witt A, Anastasiou V, Chrousos G, Yi CX, García-Cáceres C, Tschöp MH, Bornstein SR, Androutsellis-Theotokis A.
Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain
Sci Rep.Jul 27;8(1):11335. doi: 10.1038/s41598-018-29434-2, 2018 Pubmed
U Din M, Saari T, Raiko J, Kudomi N, Maurer SF, Lahesmaa M, Fromme T, Amri EZ, Klingenspor M, Solin O, Nuutila P, Virtanen KA.
Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis
Cell Metab. Aug 7;28(2):207-216.e3. doi: 10.1016/j.cmet.2018.05.020. Epub 2018 Jun 14, 2018 Pubmed
Borchard S, Bork F, Rieder T, Eberhagen C, Popper B, Lichtmannegger J, Schmitt S, Adamski J, Klingenspor M, Weiss KH, Zischka H.
The exceptional sensitivity of brain mitochondria to copper
Toxicol In Vitro.Sep;51:11-22. doi: 10.1016/j.tiv.2018.04.012. Epub 2018 Apr 30, 2018 Pubmed
André V, Gau C, Scheideler A, Aguilar-Pimentel JA, Amarie OV, Becker L, Garrett L, Hans W, Hölter SM, Janik D, Moreth K, Neff F, Östereicher M, Racz I, Rathkolb B, Rozman J, Bekeredjian R, Graw J, Klingenspor M, Klopstock T, Ollert M, Schmidt-Weber C, Wolf E, Wurst W, Gailus-Durner V, Brielmeier M, Fuchs H, Hrabé de Angelis M.
Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data PLoS Biol. Apr 16;16(4):e2005019. doi: 10.1371/journal.pbio.2005019, 2018 Pubmed
Braun K, Oeckl J, Westermeier J, Li Y, Klingenspor M.
Non-adrenergic control of lipolysis and thermogenesis in adipose tissues. J Exp Biol.Mar 7;221(Pt Suppl 1). pii: jeb165381. doi: 10.1242/jeb.165381. Review, 2018 Pubmed
Reber J, Willershäuser M, Karlas A, Paul-Yuan K, Diot G, Franz D, Fromme T, Ovsepian SV, Bézière N, Dubikovskaya E, Karampinos DC, Holzapfel C, Hauner H, Klingenspor M, Ntziachristos V.
Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients Cell Metab.Mar 6;27(3):689-701.e4. doi: 10.1016/j.cmet.2018.02.002, 2018 Pubmed
Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH.
Animal models of obesity and diabetes mellitus. Nat Rev Endocrinol. Mar;14(3):140-162. doi: 10.1038/nrendo.2017.161. Epub 2018 Jan 19. Review, 2018 Pubmed
Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H; IMPC Consortium, Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M.
Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun.Jan 18;9(1):288. doi: 10.1038/s41467-017-01995-2, 2018 Pubmed
Ghandour RA, Colson C, Giroud M, Maurer S, Rekima S, Ailhaud GP, Klingenspor M, Amri EZ, Pisani DF.
Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function.
J Lipid Res. Jan 17. pii: jlr.M081091. doi: 10.1194/jlr.M081091. [Epub ahead of print], 2018 Pubmed
Fromme T, Kleigrewe K, Dunkel A, Retzler A, Li Y, Maurer S, Fischer N, Diezko R, Kanzleiter T, Hirschberg V, Hofmann T, Klingenspor M.
Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity. Mol Metab.Feb;8:77-85. doi: 10.1016/j.molmet.2017.12.010. Epub 2017 Dec 26.; 2018 Pubmed
2017
Fuchs H, Aguilar-Pimentel JA, Amarie OV, Becker L, Calzada-Wack J, Cho YL, Garrett L, Hölter SM, Irmler M, Kistler M, Kraiger M, Mayer-Kuckuk P, Moreth K, Rathkolb B, Rozman J, da Silva Buttkus P, Treise I, Zimprich A, Gampe K, Hutterer C, Stöger C, Leuchtenberger S, Maier H, Miller M, Scheideler A, Wu M, Beckers J, Bekeredjian R, Brielmeier M, Busch DH, Klingenspor M, Klopstock T, Ollert M, Schmidt-Weber C, Stöger T, Wolf E, Wurst W, Yildirim AÖ, Zimmer A, Gailus-Durner V, Hrabě de Angelis M. Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
Behav Brain Res.Sep 29. pii: S0166-4328(17)30931-2. doi: 10.1016/j.bbr.2017.09.048. [Epub ahead of print] Review, 2017 Pubmed
Kumar S, Rathkolb B, Sabrautzki S, Krebs S, Kemter E, Becker L, Beckers J, Bekeredjian R, Brommage R, Calzada-Wack J, Garrett L, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Moreth K, Neff F, Rozman J, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Wolf E, Aigner B. Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice J Biomed Sci. Aug.;24(1):57. doi: 10.1186/s12929-017-0365-5; 2017 Pubmed
Xie K, Neff F, Markert A, Rozman J, Aguilar-Pimentel JA, Amarie OV, Becker L, Brommage R, Garrett L, Henzel KS, Hölter SM, Janik D, Lehmann I, Moreth K, Pearson BL, Racz I, Rathkolb B, Ryan DP, Schröder S, Treise I, Bekeredjian R, Busch DH, Graw J, Ehninger G, Klingenspor M, Klopstock T, Ollert M, Sandholzer M, Schmidt-Weber C, Weiergräber M, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Ehninger D. Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice. Nat Commun. Jul 24;8(1):155. doi: 10.1038/s41467-017-00178-3, 2017 PubMed
Schommers P, Thurau A, Bultmann-Mellin I, Guschlbauer M, Klatt AR, Rozman J, Klingenspor M, de Angelis MH, Alber J, Gründemann D, Sterner-Kock A, Wiesner RJ. Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state. Mol Metab. May 5;6(7):737-747. doi: 10.1016/j.molmet.2017.05.002. eCollection 2017 Jul., 2017 PubMed
Garrett L, Becker L, Rozman J, Puk O, Stoeger T, Yildirim AÖ, Bohla A, Eickelberg O, Hans W, Prehn C, Adamski J, Klopstock T, Rácz I, Zimmer A, Klingenspor M, Fuchs H, Gailus-Durner V, Wurst W, Hrabě de Angelis M, Graw J, Hölter SM. Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice. Mol Neurobiol.Jul 10. doi: 10.1007/s12035-017-0659-3. [Epub ahead of print], 2017 PubMed
Salminen AV, Garrett L, Schormair B, Rozman J, Giesert F, Niedermeier KM, Becker L, Rathkolb B, Rácz I; German Mouse Clinic Consortium, Klingenspor M, Klopstock T, Wolf E, Zimmer A, Gailus-Durner V, Torres M, Fuchs H, de Angelis MH, Wurst W, Hölter SM, Winkelmann J. Meis1 effects on motor phenotypes and the sensorimotor system in mice. Dis Model Mech.Jun 23. pii: dmm.030080. doi: 10.1242/dmm.030080. [Epub ahead of print], 2017 PubMed
Bolze F, Mocek S, Zimmermann A, Klingenspor M. Aminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes. Sci Rep. Apr 21;7(1):1020. doi: 10.1038/s41598-017-01093-9, 2017 PubMed
Ryan DP, Henzel KS, Pearson BL, Siwek ME, Papazoglou A, Guo L, Paesler K, Yu M, Müller R, Xie K, Schröder S, Becker L, Garrett L, Hölter SM, Neff F, Rácz I, Rathkolb B, Rozman J, Ehninger G, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Sidiropoulou K, Weiergräber M, Zhou Y, Ehninger D. A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice. Mol Psychiatry. Apr 4. doi: 10.1038/mp.2017.53. [Epub ahead of print], 2017 PubMed
Gimpfl M, Rozman J, Dahlhoff M, Kübeck R, Blutke A, Rathkolb B, Klingenspor M, Hrabě de Angelis M, Öner-Sieben S, Seibt A, Roscher AA, Wolf E, Ensenauer R. Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice.
Biochim Biophys Acta.Jun;1863(6):1605-1614. doi: 10.1016/j.bbadis.2017.02.021. Epub Feb 21, 2017 PubMed
Kless C, Rink N, Rozman J, Klingenspor M. Proximate causes for diet-induced obesity in laboratory mice: a case study. Eur J Clin Nutr. Mar;71(3):306-317. doi: 10.1038/ejcn.2016.243. Epub Feb 1. Review., 2017 PubMed
Gerngroß C, Schretter J, Klingenspor M, Schwaiger M, Fromme T. Active Brown Fat During 18F-FDG PET/CT Imaging Defines a Patient Group with Characteristic Traits and an Increased Probability of Brown Fat Redetection. J Nucl Med.Jul;58(7):1104-1110. doi: 10.2967/jnumed.116.183988. Epub Jan 19., 2017 PubMed
Tews D, Fromme T, Keuper M, Hofmann SM, Debatin KM, Klingenspor M, Wabitsch M, Fischer-Posovszky P.Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells. Mol Cell Endocrinol.Mar 5;443:106-113. doi: 10.1016/j.mce.2017.01.015. Jan 11., 2017 PubMed
2016
Barquissau V, Ghandour RA, Ailhaud G, Klingenspor M, Langin D, Amri EZ, Pisani DF. Control of adipogenesis by oxylipins, GPCRs and PPARs. Biochimie.Dec 27. pii: S0300-9084(16)30317-0. doi: 10.1016/j.biochi.2016.12.012. [Epub ahead of print] Review, 2016 PubMed
Li Y, Fromme T, Klingenspor M. Meaningful respirometric measurements of UCP1-mediated thermogenesis.
Biochimie.Dec 14. pii: S0300-9084(16)30320-0. doi: 10.1016/j.biochi.2016.12.005. [Epub ahead of print], 2016 PubMed
Zimprich A, Mroz G, Meyer Zu Reckendorf C, Anastasiadou S, Förstner P, Garrett L, Hölter SM, Becker L, Rozman J, Prehn C, Rathkolb B, Moreth K, Wurst W, Klopstock T, Klingenspor M, Adamski J, Wolf E, Bekeredjian R, Fuchs H, Gailus-Durner V, de Angelis MH, Knöll B. Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms. Mol Neurobiol. [Epub ahead of print], Dec 2, 2016 PubMed
Kübeck R, Bonet-Ripoll C, Hoffmann C, Walker A, Müller VM, Schüppel VL, Lagkouvardos I, Scholz B, Engel KH, Daniel H, Schmitt-Kopplin P, Haller D, Clavel T, Klingenspor M. Dietary fat and gut microbiota interactions determine diet-induced obesity in mice. Mol Metab. Oct 13;5(12):1162-1174, 2016 PubMed
Fuchs H, Sabrautzki S, Przemeck GK, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, Östereicher MA, Hans W, Abe K, Sagawa N, Rozman J, Vargas-Panesso IL, Sandholzer M, Lisse TS, Adler T, Aguilar-Pimentel JA, Calzada-Wack J, Ehrhard N, Elvert R, Gau C, Hölter SM, Micklich K, Moreth K, Prehn C, Puk O, Racz I, Stoeger C, Vernaleken A, Michel D, Diener S, Wieland T, Adamski J, Bekeredjian R, Busch DH, Favor J, Graw J, Klingenspor M, Lengger C, Maier H, Neff F, Ollert M, Stoeger T, Yildirim AÖ, Strom TM, Zimmer A, Wolf E, Wurst W, Klopstock T, Beckers J, Gailus-Durner V, Hrabě de Angelis M.
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations. G3 (Bethesda).Nov 4. pii: g3.116.033670. doi: 10.1534/g3.116.033670. [Epub ahead of print], 2016 PubMed
Berger E, Rath E, Yuan D, Waldschmitt N, Khaloian S, Allgäuer M, Staszewski O, Lobner EM, Schöttl T, Giesbertz P, Coleman OI, Prinz M, Weber A, Gerhard M, Klingenspor M, Janssen KP, Heikenwalder M, Haller D. Mitochondrial function controls intestinal epithelial stemness and proliferation. Nat Commun.Oct 27;7:13171. doi: 10.1038/ncomms13171, 2016 PubMed
Lohr K, Pachl F, Moghaddas Gholami A, Geillinger KE, Daniel H, Kuster B, Klingenspor M. Reduced mitochondrial mass and function add to age-related susceptibility toward diet-induced fatty liver in C57BL/6J mice. Physiol Rep.Oct;4(19). pii: e12988, 2016 PubMed
Sabrautzki S, Sandholzer MA, Lorenz-Depiereux B, Brommage R, Przemeck G, Vargas Panesso IL, Vernaleken A, Garrett L, Baron K, Yildirim AO, Rozman J, Rathkolb B, Gau C, Hans W, Hoelter SM, Marschall S, Stoeger C, Becker L, Fuchs H, Gailus-Durner V, Klingenspor M, Klopstock T, Lengger C, Stefanie L, Wolf E, Strom TM, Wurst W, de Angelis MH. Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation. Mamm Genome.Dec;27(11-12):587-598, 2016 PubMed
Bolze F, Bast A, Mocek S, Morath V, Yuan D, Rink N, Schlapschy M, Zimmermann A, Heikenwalder M, Skerra A, Klingenspor M. Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation. Diabetologia.Sep;59(9):2005-12. doi: 10.1007/s00125-016-4004-6, 2016 PubMed
Kumar S, Rathkolb B, Kemter E, Sabrautzki S, Michel D, Adler T, Becker L, Beckers J, Busch DH, Garrett L, Hans W, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Rácz I, Rozman J, Vargas Panesso IL, Vernaleken A, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Wolf E, Aigner B. Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice. PLoS One. Mar 22;11(3):e0150472. doi: 10.1371/journal.pone.0150472. eCollection 2016 PubMed
Kistler M, Muntean A, Szymczak W, Rink N, Fuchs H, Gailus-Durner V, Wurst W, Hoeschen C, Klingenspor M, Hrabě de Angelis M, Rozman J. Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice. J Breath Res. Feb 10;10(1):016009. doi: 10.1088/1752-7155/10/1/016009, 2016 PubMed
Korner G, Scherer T, Adamsen D, Rebuffat A, Crabtree M, Rassi A, Scavelli R, Homma D, Ledermann B, Konrad D, Ichinose H, Wolfrum C, Horsch M, Rathkolb B, Klingenspor M, Beckers J, Wolf E, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Blau N, Rozman J, Thöny B.J Inherit Metab Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice. Dis. Mar;39(2):309-19. doi: 10.1007/s10545-015-9909-6. Epub 2016 Feb 1,2016 PubMed
2015
Maurer SF, Fromme T, Grossman LI, Hüttemann M, Klingenspor M. The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice. Sci Rep.Dec 4;5:17704. doi: 10.1038/srep17704, 2015 download
Bolze F, Morath V, Bast A, Rink N, Schlapschy M, Mocek S, Skerra A, Klingenspor M. Long-acting PASylated leptin ameliorates obesity by promoting satiety and preventing hypometabolism in leptin-deficient Lepob/ob mice. Endocrinology. Oct 22;en20151519, 2015 download
Schöttl T, Kappler L, Fromme T, Klingenspor M. Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status. Mol Metab 4, 631-642, 2015 download
de Angelis MH, Nicholson G, Selloum M, White JK, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, André P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, Bedu E, Bekeredjian R, Birling MC, Blake A, Bottomley J, Bowl MR, Brault V, Busch DH, Bussell JN, Calzada-Wack J, Cater H, Champy MF, Charles P, Chevalier C, Chiani F, Codner GF, Combe R, Cox R, Dalloneau E, Dierich A, Di Fenza A, Doe B, Duchon A, Eickelberg O, Esapa CT, Fertak LE, Feigel T, Emelyanova I, Estabel J, Favor J, Flenniken A, Gambadoro A, Garrett L, Gates H, Gerdin AK, Gkoutos G, Greenaway S, Glasl L, Goetz P, Da Cruz IG, Götz A, Graw J, Guimond A, Hans W, Hicks G, Hölter SM, Höfler H, Hancock JM, Hoehndorf R, Hough T, Houghton R, Hurt A, Ivandic B, Jacobs H, Jacquot S, Jones N, Karp NA, Katus HA, Kitchen S, Klein-Rodewald T, Klingenspor M, Klopstock T, Lalanne V, Leblanc S, Lengger C, le Marchand E, Ludwig T, Lux A, McKerlie C, Maier H, Mandel JL, Marschall S, Mark M, Melvin DG, Meziane H, Micklich K, Mittelhauser C, Monassier L, Moulaert D, Muller S, Naton B, Neff F, Nolan PM, Nutter LM, Ollert M, Pavlovic G, Pellegata NS, Peter E, Petit-Demoulière B, Pickard A, Podrini C, Potter P, Pouilly L, Puk O, Richardson D, Rousseau S, Quintanilla-Fend L, Quwailid MM, Racz I, Rathkolb B, Riet F, Rossant J, Roux M, Rozman J, Ryder E, Salisbury J, Santos L, Schäble KH, Schiller E, Schrewe A, Schulz H, Steinkamp R, Simon M, Stewart M, Stöger C, Stöger T, Sun M, Sunter D, Teboul L, Tilly I, Tocchini-Valentini GP, Tost M, Treise I, Vasseur L, Velot E, Vogt-Weisenhorn D, Wagner C, Walling A, Wattenhofer-Donze M, Weber B, Wendling O, Westerberg H, Willershäuser M, Wolf E, Wolter A, Wood J, Wurst W, Yildirim AÖ, Zeh R, Zimmer A, Zimprich A; EUMODIC Consortium, Holmes C, Steel KP, Herault Y, Gailus-Durner V, Mallon AM, Brown SD.
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
Nat Genet. Jul 27, 2015 [Epub ahead of print] PubMed
Deng T, Zhu ZI, Zhang S, Postnikov Y, Huang D, Horrsch M, Furusawa T, Beckers J, Rozman J, Klingenspor M, Amarie O, Graw J, Rathkolb B, Wolf E, Adler T, Busch DH, Galius-Durner V, Fuchs H, Hrabe de Angelis M, van der Velde A, Tessarollo L, Ovcherenko I, Landsman D, Bustin M.
Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.
Genome Res.Jul 8, 2015 [Epub ahead of print] PubMed
Fischer B, Schöttl T, Schempp C, Fromme T, Hauner H, Klingenspor M, Skurk T.
Inverse relationship between body mass index and mitochondrial oxidative phosphorylation capacity in human subcutaneous adipocytes.
Am J Physiol Endocrinol Metab. Jun 16, 2015 [Epub ahead of print] PubMed
Morath V, Bolze F, Schlapschy M, Schneider S, Sedlmayer F, Seyfarth K, Klingenspor M, Skerra A.
PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy.
Mol Pharm. May 4;12(5):1431-42, 2015 PubMed
Kless C, Müller VM, Schüppel VL, Lichtenegger M, Rychlik M, Daniel H, Klingenspor M, Haller D.
Diet-induced obesity causes metabolic impairment independent of alterations in gut barrier integrity.
Mol Nutr Food Res. May;59(5):968-78, 2015 PubMed
Rozman J, Rathkolb B, Neschen S, Fuchs H, Gailus-Durner V, Klingenspor M, Wolf E, Hrabě de Angelis M.
Glucose tolerance tests for systematic screening of glucose homeostasis in mice.
Curr Protoc Mouse Biol. Mar 2;5(1):65-84, 2015 PubMed
Schöttl T, Kappler L, Braun K, Fromme T, Klingenspor M.
Limited mitochondrial capacity of visceral versus subcutaneous white adipocytes in male C57BL/6N mice.
Endocrinology. Mar;156(3):923-33, 2015 PubMed
Keeney JG, O'Bleness MS, Anderson N, Davis JM, Arevalo N, Busquet N, Chick W, Rozman J, Hölter SM, Garrett L, Horsch M; German Mouse Clinic Consortium, Beckers J, Wurst W, Klingenspor M, Restrepo D, de Angelis MH, Sikela JM. Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity.
Mamm Genome. Feb;26(1-2):33-42, 2015 PubMed
Seyfarth K, Poschmann G, Rozman J, Fromme T, Rink N, Hofmann A, Wurst W, Stühler K, Klingenspor M.
The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice.
J Nutr Biochem. Jan;26(1):75-81, 2015 PubMed
2014
Walker A, Pfitzner B, Neschen S, Kahle M, Harir M, Lucio M, Moritz F, Tziotis D, Witting M, Rothballer M, Engel M, Schmid M, Endesfelder D, Klingenspor M, Rattei T, Castell WZ, de Angelis MH, Hartmann A, Schmitt-Kopplin P. Distinct signatures of host-microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet. ISME J. Dec;8(12):2380-96. 2014 PubMed
Li Y, Fromme T, Schweizer S, Schöttl T, Klingenspor M. Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes.
EMBO Rep. Oct;15(10):1069-76, 2014 PubMed
Rozman J, Klingenspor M, Hrabě de Angelis M. A review of standardized metabolic phenotyping of animal models. Mamm Genome. Oct;25(9-10):497-507, 2014 Pubmed
Li Y, Bolze F, Fromme T, Klingenspor M. Intrinsic differences in BRITE adipogenesis of primary adipocytes from two different mouse strains. Biochim Biophys Acta. Sep;1841(9):1345-52, 2014 PubMed
Tews D, Schwar V, Scheithauer M, Weber T, Fromme T, Klingenspor M, Barth TF, Möller P, Holzmann K, Debatin KM, Fischer-Posovszky P, Wabitsch M. Comparative gene array analysis of progenitor cells from human paired deep neck and subcutaneous adipose tissue. Mol Cell Endocrinol. Sep;395(1-2):41-50, 2014 PubMed
Lang R, Fromme T, Beusch A, Lang T, Klingenspor M, Hofmann T. Raw coffee based dietary supplements contain carboxyatractyligenin derivatives inhibiting mitochondrial adenine-nucleotide-translocase.
Food Chem Toxicol. Aug;70:198-204, 2014 PubMed
Li Y, Lasar D, Fromme T, Klingenspor M. White, brite, and brown adipocytes: the evolution and function of a heater organ in mammals.Canadian Journal of Zoology July; 92(7): 615-626. 2014 go to journal website
Poschmann G, Seyfarth K, Besong Agbo D, Klafki HW, Rozman J, Wurst W, Wiltfang J, Meyer HE, Klingenspor M, Stühler K. High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.
J Proteome Res. May 2;13(5):2339-51, 2014 PubMed
Stribl C, Samara A, Trümbach D, Peis R, Neumann M, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Rathkolb B, Wolf E, Beckers J, Horsch M, Neff F, Kremmer E, Koob S, Reichert AS, Hans W, Rozman J, Klingenspor M, Aichler M, Walch AK, Becker L, Klopstock T, Glasl L, Hölter SM, Wurst W, Floss T.
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.
J Biol Chem. Apr 11;289(15):10769-84, 2014 Pubmed
Spieler D, Kaffe M, Knauf F, Bessa J, Tena JJ, Giesert F, Schormair B, Tilch E, Lee H, Horsch M, Czamara D, Karbalai N, von Toerne C, Waldenberger M, Gieger C, Lichtner P, Claussnitzer M, Naumann R, Müller-Myhsok B, Torres M, Garrett L, Rozman J, Klingenspor M, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Beckers J, Hölter SM, Meitinger T, Hauck SM, Laumen H, Wurst W, Casares F, Gómez-Skarmeta JL, Winkelmann J. Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res. Apr;24(4):592-603, 2014 PubMed
Kistler M, Szymczak W, Fedrigo M, Fiamoncini J, Höllriegl V, Hoeschen C, Klingenspor M, Hrabě de Angelis M, Rozman J. Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice.
J Breath Res. Mar;8(1):016004, 2014 PubMed
Kraus P, V S, Yu HB, Xing X, Lim SL, Adler T, Pimentel JA, Becker L, Bohla A, Garrett L, Hans W, Hölter SM, Janas E, Moreth K, Prehn C, Puk O, Rathkolb B, Rozman J, Adamski J, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Neff F, Ollert M, Stoeger T, Yildrim AÖ, Eickelberg O, Wolf E, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Lufkin T, Stanton LW. Pleiotropic functions for transcription factor zscan10. PLoS One. Aug 11;9(8):e104568, 2014. Pubmed
Knoll N, Jarick I, Volckmar AL, Klingenspor M, Illig T, Grallert H, Gieger C, Wichmann HE, Peters A, Wiegand S, Biebermann H, Fischer-Posovszky P, Wabitsch M, Völzke H, Nauck M, Teumer A, Rosskopf D, Rimmbach C, Schreiber S, Jacobs G, Lieb W, Franke A, Hebebrand J, Hinney A.
Mitochondrial DNA variants in obesity.
PLoS One. May 2;9(5):e94882, 2014 Pubmed
Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium, Spieler D, Klingenspor M,Seifert M, Kern MJ, Mejhert N, Dahlman I,Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K,Hsu YH, Mellgren G, Hauner H, Laumen H.
Leveraging cross-species transcription factor binding site patterns: from diabetes risk Loci to disease mechanisms.
Cell. Jan 16;156(1-2):343-58, 2014 PubMed
2013
Hoffmann C, Zimmermann A, Hinney A, Volckmar AL, Jarrett HW, Fromme T, Klingenspor M.
A Novel SP1/SP3 Dependent Intronic Enhancer Governing Transcription of the UCP3 Gene in Brown Adipocytes.
PLoS One. Dec 31;8(12):e83426, 2013 PubMed
Hölter SM, Stromberg M, Kovalenko M, Garrett L, Glasl L, Lopez E, Guide J, Götz A, Hans W, Becker L, Rathkolb B, Rozman J, Schrewed A, Klingenspor M, Klopstock T, Schulz H, Wolf E, Wursta W, Gillis T, Wakimoto H, Seidman J, MacDonald ME, Cotman S, Gailus-Durner V, Fuchs H, de Angelis MH, Lee JM, Wheeler VC.
A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.
PLoS One. Nov 22;8(11):e80923, 2013 PubMed
Szymczak W, Rozman J, Höllriegl V, Kistler M, Keller S, Peters D, Kneipp M, Schulz H, Hoeschen C, Klingenspor M, Hrabě de Angelis M.
Online breath gas analysis in unrestrained mice by hs-PTR-MS.
Mamm Genome. Apr;25(3-4):129-40, 2013 PubMed
Dahlhoff M, Pfister S, Blutke A, Rozman J, Klingenspor M, Deutsch MJ, Rathkolb B, Fink B, Gimpfl M, Hrabě de Angelis M, Roscher AA, Wolf E, Ensenauer R.
Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.
Biochim Biophys Acta. Feb;1842(2):304-17, 2013 PubMed
Kemter E, Prückl P, Rathkolb B, Micklich K, Adler T, Becker L, Beckers J, Busch DH, Götz AA, Hans W, Horsch M, Ivandic B, Klingenspor M, Klopstock T, Rozman J, Schrewe A, Schulz H, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Wolf E, Aigner B.
Standardized, Systemic Phenotypic Analysis of Umod (C93F) and Umod (A227T) Mutant Mice.
PLoS One. Oct 24;8(10):e78337, 2013 PubMed
Besong Agbo D, Klafki H, Poschmann G, Seyfarth K, Genius J, Janßen C, Stühler K, Wurst W, Meyer HE, Klingenspor M, Wiltfang J.
Development of a capillary isoelectric focusing immunoassay to measure DJ-1 isoforms in biological samples.
Anal Biochem. Dec 15;443(2):197-204, 2013 PubMed
Schöttl T, Klingenspor M.
Boosting mitochondrial biogenesis in white adipocytes: A route towards improved insulin sensitivity?
Mol Metab. Jul 10;2(3):128-9, 2013 PubMed
Gruber L, Kisling S, Lichti P, Martin FP, May S, Klingenspor M, Lichtenegger M, Rychlik M, Haller D.
High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity.
PLoS One. Aug 16;8(8):e71661, 2013 Pubmed
Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Hölter SM, Moreth K, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Naton B, Ordemann R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Ehninger G, Graw J, Höfler H, Klingenspor M, Klopstock T, Ollert M, Stypmann J, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Ehninger D.
Rapamycin extends murine lifespan but has limited effects on aging.
J Clin Invest. Aug;123(8):3272-91, 2013 Pubmed
Tews D, Fischer-Posovszky P, Fromme T, Klingenspor M, Fischer J, Rüther U, Marienfeld R, Barth T, Möller P, Debatin K, Wabitsch M.
FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes
Endocrinology. Sep;154(9):3141-51, 2013 Pubmed
Geiser F, Klingenspor M, McAllan BM.
A functional nexus between photoperiod acclimation, torpor expression and somatic fatty acid composition in a heterothermic mammal.
PLoS One. May 22;8(5):e63803, 2013 Pubmed
Lang R, Fromme T, Beusch A, Wahl A, Klingenspor M, Hofmann T.
2-O-β-d-Glucopyranosyl-carboxyatractyligenin from Coffea L. inhibits adenine nucleotide translocase in isolated mitochondria but is quantitatively degraded during coffee roasting.
Phytochemistry. Sep;93:124-35, 2013 Pubmed
Nordström V, Willershäuser M, Herzer S, Rozman J, von Bohlen Und Halbach O, Meldner S, Rothermel U, Kaden S, Roth FC, Waldeck C, Gretz N, de Angelis MH, Draguhn A, Klingenspor M, Gröne HJ, Jennemann R.
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.
PLoS Biol. 11(3):e1001506, 2013 Pubmed
Ju L, Wing J, Taylor E, Brandt R, Slijepcevic P, Horsch M, Rathkolb B, Rácz I, Becker L, Hans W, Adler T, Beckers J, Rozman J, Klingenspor M, Wolf E, Zimmer A, Klopstock T, Busch DH, Gailus-Durner V, Fuchs H, de Angelis MH, van der Horst G, Lehmann AR.
SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.
DNA Repair (Amst).May 1;12(5):356-66, 2013 Pubmed
Knoll N, Jarick I, Volckmar AL, Klingenspor M, Illig T, Grallert H, Gieger C, Wichmann HE, Peters A, Hebebrand J, Scherag A, Hinney A.
Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity.
PLoS One.Feb;8(2):e55884, 2013. Pubmed
Lasar D, Julius A, Fromme T, Klingenspor M.
Browning attenuates murine white adipose tissue expansion during postnatal development.
Biochim Biophys Acta (BBA) - Molecular and Cell Biology of Lipids. Jan;30: S1388-1981, 2013 Pubmed
Helwig M, Herwig A, Heldmaier G, Barrett P, Mercer JG, Klingenspor M.
Photoperiod-dependent regulation of carboxypeptidase E affects selective processing of neuropeptides in the seasonal Siberian hamster (Phodopus sungorus).
J Neuroendocrinol. Feb;25(2):190-7, 2013 Pubmed
2012
Volckmar AL, Bolze F, Jarick I, Knoll N, Scherag A, Reinehr T, Illig T, Grallert H, Wichmann HE, Wiegand S, Biebermann H, Krude H, Fischer-Posovszky P, Rief W, Wabitsch M, Klingenspor M, Hebebrand J, Hinney A.
Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.
BMC Med Genomics.2012 Dec 27. Pubmed
Klingenspor M, Herzig S, Pfeifer A.
Brown Fat Develops a Brite Future.
Obes Facts. Dec 22;5(6):890-896, 2012 Pubmed
Hochrath K, Krawczyk M, Goebel R, Langhirt M, Rathkolb B, Micklich K, Rozman J, Horsch M, Beckers J, Klingenspor M, Fuchs H, Gailus-Durner V, Wolf E, Acalovschi M, Volmer DA, Hrabe de Angelis M, Lammert F.
The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis.
FASEB J. Dec;26(12):5081-91, 2012 Pubmed
Helwig M, Herwig A, Heldmaier G, Barrett P, Mercer JG, Klingenspor M.
Photoperiod-dependent regulation of carboxypeptidase E affects selective processing of neuropeptides in the seasonal Siberian hamster (Phodopus sungorus).
J Neuroendocrinol. Feb;25(2):190-7, 2012 Pubmed
Fuchs H, Gailus-Durner V, Neschen S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Bohla A, Calzada-Wack J, Cohrs C, Dewert A, Fridrich B, Garrett L, Glasl L, Götz A, Hans W, Hölter SM, Horsch M, Hurt A, Janas E, Janik D, Kahle M, Kistler M, Klein-Rodewald T, Lengger C, Ludwig T, Maier H, Marschall S, Micklich K, Möller G, Naton B, Prehn C, Puk O, Rácz I, Räß M, Rathkolb B, Rozman J, Scheerer M, Schiller E, Schrewe A, Steinkamp R, Stöger C, Sun M, Szymczak W, Treise I, Vargas Panesso IL, Vernaleken AM, Willershäuser M, Wolff-Muscate A, Zeh R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Eickelberg O, Favor J, Graw J, Höfler H, Höschen C, Katus H, Klingenspor M, Klopstock T, Neff F, Ollert M, Schulz H, Stöger T, Wolf E, Wurst W, Yildirim AO, Zimmer A, Hrabě de Angelis M.
Innovations in phenotyping of mouse models in the German Mouse Clinic.
Mamm Genome. Oct;23(9-10):611-22, 2012. Pubmed
Desmarchelier C, Ludwig T, Scheundel R, Rink N, Bader BL, Klingenspor M, Daniel H.
Diet-induced obesity in ad libitum-fed mice: food texture overrides the effect of macronutrient composition.
Br J Nutr. Aug 6:1-10, 2012. Pubmed
Lee AW, Hengstler H, Schwald K, Berriel-Diaz M, Loreth D, Kirsch M, Kretz O, Haas CA, de Angelis MH, Herzig S, Brümmendorf T, Klingenspor M, Rathjen FG, Rozman J, Nicholson G, Cox RD, Schäfer MK.
Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype.
PLoS One. 7(7):e41537, 2012. Pubmed
Fuchs H, Sabrautzki S, Seedorf H, Rathkolb B, Rozman J, Hans W, Schneider R, Klaften M, Hölter SM, Becker L, Klempt M, Elvert R, Wurst W, Klopstock T, Klingenspor M, Wolf E, Gailus-Durner V, de Angelis MH.
Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines.
Eur J Oral Sci. Aug;120(4):269-77, 2012. Pubmed
Hüttemann M, Lee I, Gao X, Pecina P, Pecinova A, Liu J, Aras S, Sommer N, Sanderson TH, Tost M, Neff F, Aguilar-Pimentel JA, Becker L, Naton B, Rathkolb B, Rozman J, Favor J, Hans W, Prehn C, Puk O, Schrewe A, Sun M, Höfler H, Adamski J, Bekeredjian R, Graw J, Adler T, Busch DH, Klingenspor M, Klopstock T, Ollert M, Wolf E, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Weissmann N, Doan JW, Bassett DJ, Grossman LI.
Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.
FASEB J. Sep;26(9):3916-30, 2012. Pubmed
Irmler M, Gentier RJ, Dennissen FJ, Schulz H, Bolle I, Hölter SM, Kallnik M, Cheng JJ, Klingenspor M, Rozman J, Ehrhardt N, Hermes DJ, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Meyer HE, Hopkins DA, Van Leeuwen FW, Beckers J.
Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.
Acta Neuropathol. Aug;124(2):187-97, 2012. Pubmed
Staropoli JF, Haliw L, Biswas S, Garrett L, Hölter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun M, Favor J, Racz I, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Lopez E, Harati H, Hill E, Krause DS, Guide J, Dragileva E, Gale E, Wheeler VC, Boustany RM, Brown DE, Breton S, Ruether K, Gailus-Durner V, Fuchs H, de Angelis MH, Cotman SL.
Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system.
PLoS One. 7(6):e38310, 2012. Pubmed
Klingenspor M, Fromme, T
Brown Adipose Tissue. pp39-69, 2012
In: Adipose Tissue Biology; edited by Symonds MEE; Springer New York Link
Jastroch M, Hirschberg V, Klingenspor M
Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak.
Biochim Biophys Acta Sep;1817(9):1660-70, 2012. Pubmed
Olszewski PK, Rozman J, Jacobsson JA, Rathkolb B, Strömberg S, Hans W, Klockars A, Alsiö A, Risérus U, Becker L, Hölter SM, Elvert R, Ehrhardt N, Gailus-Durner V, Fuchs H, Fredriksson R, Wolf E, Klopstock T, Wurst W, Levine AS, Marcus C, Hrabé de Angelis M, Klingenspor M, Schiöth HB, Kilimann MW.Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans.
PLoS Genet 8(3): e1002568, 2012. open access
Tups A, Stöhr S, Helwig M, Barrett P, Krol E, Schachtner J, Mercer JG, Klingenspor M.
Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein.
J Comp Physiol B May;182(4):553-67, 2012 Pubmed
Grünz G, Haas K, Soukup S, Klingenspor M, Kulling SE, Daniel H, Spanier B.
Structural features and bioavailability of four flavonoids and their implications for lifespan-extending and antioxidant actions in C. elegans.
Mech Ageing Dev. Jan;133(1):1-10, 2012 Pubmed
2011
Baur P, Martin FP, Gruber L, Bosco N, Brahmbhatt V, Collino S, Guy P, Montoliu I, Rozman J, Klingenspor M, Tavazzi I, Thorimbert A, Rezzi S, Kochhar S, Benyacoub J, Kollias G, Haller D.
Metabolic phenotyping of the Crohn's Disease-like IBD etiopathology in the TNF(ΔARE/WT) mouse model.
J Proteome Res. Dec 2;10(12):5523-35, 2011 Pubmed
Hirschberg V ,Fromme T, Klingenspor M.
Test systems to study the structure and function of uncoupling protein 1: a critical overview.
Frontiers in Endocrinology 2, 2011 free online access
Bolze F, Rink N, Brumm H, Kühn R, Mocek S, Schwarz AE, Kless C, Biebermann H, Wurst W, Rozman J, Klingenspor M.
Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo.
Pharmacogenomics J 2011 Oct 4. doi: 10.1038/tpj.2011.43. [Epub ahead of print]
Gotz AA, Rozman J, Rodel HG, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Klingenspor M, Stoeger T.
Comparison of particle-exposure triggered pulmonary and systemic inflammation in mice fed with three different diets.
Part Fibre Toxicol Sep 27;8(1):30, 2011. [Pubmed]
Raab M, Kappel S, Krämer A, Sanhaji M, Matthess Y, Kurunci-Csacsko E, Calzada-Wack J, Rathkolb B, Rozman J, Adler T, Busch DH, Esposito I, Fuchs H, Gailus-Durner V, Klingenspor M, Wolf E, Sänger N, Prinz F, Angelis MH, Seibler J, Yuan J, Bergmann M, Knecht R, Kreft B, Strebhardt K.
Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells.
Nat Commun Jul 19;2:395, 2011. Pubmed
Brumm H, Mühlhaus J, Bolze F, Scherag S, Hinney A, Hebebrand J, Wiegand S, Klingenspor M, Grüters A, Krude H, Biebermann H.
Rescue of Melanocortin 4 Receptor (MC4R) Nonsense Mutations by Aminoglycoside-Mediated Read-Through.
Obesity (Silver Spring). Jul 7, 2011. Pubmed
Polymeropoulos ET, Heldmaier G, Frappell PB, McAllan BM, Withers KW, Klingenspor M, White CR, Jastroch M.
Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak.
Proc Biol Sci Jun 1, 2011. Pubmed
Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Götz A, Hans W, Higuchi M, Hölter SM, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Esposito I, Graw J, Ivandic B, Klingenspor M, Klopstock T, Mempel M, Ollert M, Schulz H, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, de Angelis MH, Beckers J.
Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice.
J Biol Chem 286(21):18614-22, 2011. Pubmed
Abe K, Fuchs H, Boersma A, Hans W, Yu P, Kalaydjiev S, Klaften M, Adler T, Calzada-Wack J, Mossbrugger I, Rathkolb B, Rozman J, Prehn C, Maraslioglu M, Kametani Y, Shimada S, Adamski J, Busch DH, Esposito I, Klingenspor M, Wolf E, Wurst W, Gailus-Durner V, Katan M, Marschall S, Soewarto D, Wagner S, de Angelis MH.
A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.
Arthritis Rheum 63(5):1301-11, 2011. Pubmed
Fromme T and Klingenspor M.
Uncoupling protein 1 expression and high fat diets.
Am J Physiol Regul Integr Comp Physiol 300(1):R1-8, 2011. Pubmed, free PDF
Fuchs H, Durner VG, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Da Silva-Buttkus P, Neff F, Götz A, Hans W, Hölter SM, Horsch M, Kastenmüller G, Kemter E, Lengger C, Maier H, Matloka M, Möller G, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Römisch-Margl W, Rozman J, Wang-Sattler R, Schrewe A, Stöger C, Tost M, Adamski J, Aigner B, Beckers J, Behrendt H, Busch DH, Esposito I, Graw J, Illig T, Ivandic B, Klingenspor M, Klopstock T, Kremmer E, Mempe M, Neschen S, Ollert M, Schulz H, Suhre K, Wolf E, Wurst W, Zimmer A, Hrabě de Angelis M.
Mouse phenotyping.
Methods 53:120-135, 2011. Pubmed
2010
Meyer CW, Willershäuser M, Jastroch M, Rourke B, Fromme T, Oelkrug R, Heldmaier G, Klingenspor M.
Adaptive thermogenesis and thermal conductance in wildtype and UCP1-KO mice.
Am J Physiol Regul Integr Comp Physiol 299(5):R1396-406, 2010. Pubmed
Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I.
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.
EMBO J. 29(14):2421-32, 2010. Pubmed
Vegiopoulos A, Müller-Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A, Berriel Diaz M, Rozman J, Hrabe de Angelis M, Nüsing RM, Meyer CW, Wahli W, Klingenspor M, Herzig S.
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes.
Science 328(5982):1158-61, 2010. Pubmed
Scherag A, Dina C, Hinney A, Vatin V, Scherag S, Vogel CI, Müller TD, Grallert H, Wichmann HE, Balkau B, Heude B, Jarvelin MR, Hartikainen AL, Levy-Marchal C, Weill J, Delplanque J, Körner A, Kiess W, Kovacs P, Rayner NW, Prokopenko I, McCarthy MI, Schäfer H, Jarick I, Boeing H, Fisher E, Reinehr T, Heinrich J, Rzehak P, Berdel D, Borte M, Biebermann H, Krude H, Rosskopf D, Rimmbach C, Rief W, Fromme T, Klingenspor M, Schürmann A, Schulz N, Nöthen MM, Mühleisen TW, Erbel R, Jöckel KH, Moebus S, Boes T, Illig T, Froguel P, Hebebrand J, Meyre D.
Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
PLoS Genet 6(4):e1000916, 2010. Pubmed
Hesse D, Dunn M, Heldmaier G, Klingenspor M, Rozman J.
Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet- induced obesity.
Physiol Behav 99(3): 370-380, 2010. Pubmed
Tocchetti A, Soppo CB, Zani F, Bianchi F, Gagliani MC, Pozzi B, Rozman J, Elvert R, Ehrhardt N, Rathkolb B, Moerth C, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Klingenspor M, Wolf E, Hrabé de Angelis M, Scanziani E, Tacchetti C, Scita G, Di Fiore PP, Offenhäuser N.
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
PLoS One 5(3):e9468, 2010. Pubmed
Rosemann M, Ivashkevich A, Favor J, Dalke C, Hölter SM, Becker L, Rácz I, Bolle I, Klempt M, Rathkolb B, Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, Rozman J, Calzada-Wack J, Kunder S, Naton B, Gailus-Durner V, Fuchs H, Schulz H, Beckers J, Busch DH, Burbach JP, Smidt MP, Quintanilla-Martinez L, Esposito I, Klopstock T, Klingenspor M, Ollert M, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M, Atkinson M, Heinzmann U, Graw J.
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.
Mamm Genome 21(1-2):13-27, 2010. Pubmed
Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J, Wood J; EUMODIC Consortium, de Angelis MH, Brown SD, Hancock JM, Mallon AM.
EuroPhenome: a repository for high-throughput mouse phenotyping data.
Nucleic Acids Res 38(Database issue):D577-85, 2010. Pubmed
2009
Forner F, Kumar C, Luber CA, Fromme T, Klingenspor M, Mann M.
Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions.
Cell Metab 10(4):324-35, 2009. Pubmed
Singmann P, Baumert J, Herder C, Meisinger C, Holzapfel C, Klopp N, Wichmann HE, Klingenspor M, Rathmann W, Illig T, Grallert H.
Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome.
Obesity Facts 2(4): 235-242, 2009. free download
Kemter E, Rathkolb B, Rozman J, Hans W, Schrewe A, Landbrecht C, Klaften M, Ivandic BT, Fuchs H Noyes, Gailus-Durner V, Klingenspor M, Hrabe de Angelis M, Wolf E, Wanke R, Aigner B.
Novel Missense Mutation of Uromodulin in Mice Causes Renal Dysfunction with Alterations in Urea Handling, Energy and Bone Metabolism.
Am J Physiol Renal Physiol 297(5): F1391-8. 2009. Pubmed
Jastroch M, Withers KW, Stoehr S, Klingenspor M.
Mitochondrial Proton Conductance in Skeletal Muscle of a Cold-Exposed Marsupial, Antechinus flavipes, Is Unlikely to Be Involved in Adaptive Nonshivering Thermogenesis but Displays Increased Sensitivity toward Carbon-Centered Radicals.
Physiol Biochem Zool 82(5):447-54. 2009. Pubmed
Rubio-Aliaga I, Przemeck GK, Fuchs H, Gailus-Durner V, Adler T, Hans W, Horsch M, Rathkolb B, Rozman J, Schrewe A, Wagner S, Hoelter SM, Becker L, Klopstock T, Wurst W, Wolf E, Klingenspor M, Ivandic BT, Busch DH, Beckers J, Hrabé de Angelis M.
Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.
PLoS One 4(6):e6054, 2009. Pubmed
Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Moßbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, Hrabé de Angelis M, Fischer J, Schwarz J, Päabo S.
A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.
Cell 137, 961–971, 2009. Journal home page
Meyer CW, Wagener A, Rink N, Hantschel C, Heldmaier G, Klingenspor M, Brockmann GA.
High Energy Digestion Efficiency and Altered Lipid Metabolism Contribute to Obesity in BFMI Mice.
Obesity 17(11):1988-93, 2009. Pubmed
Fromme T, Hoffmann C, Nau K, Rozman J, Reichwald K, Utting M, Platzer M, Klingenspor M.
An intronic single base exchange leads to a brown adipose tissue specific loss of Ucp3 expression and an altered body mass trajectory.
Physiol Genomics 38(1):54-62, 2009. Pubmed
Helwig M, Archer ZA, Heldmaier G, Tups A, Mercer JG, Klingenspor M.
Photoperiodic regulation of satiety mediating neuropeptides in the brainstem of the seasonal Siberian hamster (Phodopus sungorus).
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 195(7):631-42, 2009. Pubmed
Bolze F, Klingenspor M.
Mouse models for the central melanocortin system.
Genes Nutr 4(2):129-34, 2009. Pubmed
Gailus-Durner V, Fuchs H, Adler T, Aguilar Pimentel A, Becker L, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Ferwagner B, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Mörth C, Mossbrugger I, Naton B, Prehn C, Puk O, Rathkolb B, Rozman J, Schrewe A, Thiele F, Adamski J, Aigner B, Behrendt H, Busch DH, Favor J, Graw J, Heldmaier G, Ivandic B, Katus H, Klingenspor M, Elisabeth Kremmer TK, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, de Angelis MH.
Systemic First-Line Phenotyping.
Methods Mol Biol 530:1-47, 2009. Pubmed
Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabe de Angelis M, Klingenspor M, Buck A, Schwaiger M, Saur D, Schmid RM, Klöppel G, Sipos B, Greten FR, Arkan MC.
Inflammation and mitochondrial fatty acid β-oxidation link obesity to early tumor promotion.
Proc Natl Acad Sci USA 106(9):3354-9, 2009. Pubmed
Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Moßbrugger I, Mörth C, Naton B, Nöth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schäble K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershäuser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, de Angelis MH.
The German Mouse Clinic: A Platform for Systemic Phenotype Analysis of Mouse Models.
Curr Pharm Biotechnol 10(2):236-243, 2009. Pubmed
Hughes DA, Jastroch M, Stoneking M, Klingenspor M.
Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis.
BMC Evol Biol 7(9):4, 2009. Open Access
2008
Jastroch M, Klingenspor M. A new look at the evolution of uncoupling protein 1-mediated non-shivering thermogenesis. In: Hypometabolism in Animals: Hibernation, torpor and cryobiology . Lovegrove BG, McKechnie AE, editors. Pietermaritzburg: Interpak Books; p 197-208, 2008.
Mzilikazi N, Meyer CW, Klingenspor M. Towards ecological relevance: a comparison of physiological and molecular evidence for the presence of adaptive, UCP1-mediated non-shivering thermogenesis in mammals. In: Hypometabolism in Animals: Hibernation, torpor and cryobiology. Lovegrove BG, McKechnie AE, editors. Pietermaritzburg: Interpak Books; p 209-14, 2008.
Diaz MB, Krones-Herzig A, Metzger D, Ziegler A, Vegiopoulos A, Klingenspor M, Müller-Decker K, Herzig S. Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice. Hepatology 48(3):782-91, 2008. Pubmed
Trzcionka M, Withers KW, Klingenspor M, Jastroch M. The effects of fasting and cold exposure on metabolic rate and mitochondrial proton leak in liver and skeletal muscle of an amphibian, the cane toad Bufo marinus. J Exp Biol 211(Pt 12):1911-8, 2008. Pubmed
Khorooshi R, Helwig M, Werckenthin A, Steinberg N, Klingenspor M. Seasonal regulation of cocaine- and amphetamine-regulated transcript in the arcuate nucleus of Djungarian hamster (Phodopus sungorus). Gen Comp Endocrinol 157(2):142-7, 2008. Pubmed
Klingenspor M, Fromme T, Hughes DA Jr, Manzke L, Polymeropoulos E, Riemann T, Trzcionka M, Hirschberg V, Jastroch M. An ancient look at UCP1. Biochim Biophys Acta 1777(7-8): 637-41 2008. Pubmed
Jastroch M, Withers KW, Taudien S, Frappell PB, Helwig M, Fromme T, Hirschberg V, Heldmaier G, McAllan BM, Firth BT, Burmester T, Platzer M, Klingenspor M. Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis. Physiol Genomics 32(2):161-9, 2008. Pubmed
Nau K, Fromme T, Meyer CW, von Praun C, Heldmaier G, Klingenspor M. Brown adipose tissue specific lack of uncoupling protein 3 is associated with reduced cold tolerance and global reduction of metabolic gene expression. J Comp Physiol [B] 178(3):269-77, 2008. Pubmed
Braulke LJ, Klingenspor M, Debarber A, Tobias SC, Grandy DK, Scanlan TS, Heldmaier G. 3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation. J Comp Physiol [B] 178(2):167-77, 2008. Pubmed
2007
Fromme T and Klingenspor M. Rapid single step subcloning procedure by combined action of type II and type IIs endonucleases with ligase. Journal of Biological Engineering 1:7, 2007 Open Access
Mzilikazi N, Jastroch M, Meyer CW, Klingenspor M. The molecular and biochemical basis of non-shivering thermogenesis in an African endemic mammal, Elephantulus myurus. Am J Physiol Regul Integr Comp Physiol 293(5):R2120-7, 2007. Pubmed
Jastroch M, Buckingham JA, Helwig M, Klingenspor M, Brand MD. Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain. J Comp Physiol [B] 177(7):743-52, 2007. Pubmed
Fromme T, Reichwald K, Platzer M, Li XS, Klingenspor M. Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus sungorus. BMC Mol Biol 8:1, 2007. Pubmed
Meyer CW, Neubronner J, Rozman J, Stumm G, Osanger A, Stoeger C, Augustin M, Grosse J, Klingenspor M, Heldmaier G. Expanding the body mass range: associations between BMR and tissue morphology in wild type and mutant dwarf mice (David mice). J Comp Physiol [B] 177(2):183-92, 2007. Pubmed
Meyer CW, Elvert R, Scherag A, Ehrhardt N, Gailus-Durner V, Fuchs H, Schafer H, Hrabe de AM, Heldmaier G, Klingenspor M. Power matters in closing the phenotyping gap. Naturwissenschaften 94(5):401-6, 2007. Pubmed
Scherbarth F, Rozman J, Klingenspor M, Brabant G, Steinlechner S. Wheel running affects seasonal acclimatization of physiological and morphological traits in the Djungarian hamster (Phodopus sungorus). Am J Physiol Regul Integr Comp Physiol. 293(3):R1368-75, 2007. Pubmed
Wuertz S, Nitsche A, Jastroch M, Gessner J, Klingenspor M, Kirschbaum F, Kloas W . The role of the IGF-I system for vitellogenesis in maturing female sterlet, Acipenser ruthenus Linnaeus, 1758. Gen Comp Endocrinol 150(1):140-50, 2007. Pubmed
2006
Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, Kratky D, Wagner EF, Klingenspor M, Hoefler G, Zechner R. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312: 734-737, 2006 Pubmed
Helwig M, Khorooshi RM, Tups A, Barrett P, Archer ZA, Exner C, Rozman J, Braulke LJ, Mercer JG, Klingenspor M. PC1/3 and PC2 Gene Expression and Post-Translational Endoproteolytic Pro-Opiomelanocortin Processing is Regulated by Photoperiod in the Seasonal Siberian Hamster (Phodopus sungorus). J Neuroendocrinol 18: 413-425, 2006 Pubmed
Tups A, Helwig M, Stohr S, Barrett P, Mercer JG, Klingenspor M. Photoperiodic regulation of insulin receptor mRNA and intracellular insulin signaling in the arcuate nucleus of the Siberian hamster, Phodopus sungorus. Am J Physiol Regul Integr Comp Physiol , 2006 Pubmed
Tups A, Barrett P, Ross AW, Morgan PJ, Klingenspor M, Mercer JG. The suppressor of cytokine signalling 3, SOCS3, may be one critical modulator of seasonal body weight changes in the Siberian hamster, Phodopus sungorus. J Neuroendocrinol 18: 139-145, 2006 Pubmed
2005
Gailus-Durner V, Fuchs H, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Elvert R, Ehrhardt N, Dalke C, Franz TJ, Grundner-Culemann E, Hammelbacher S, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kalaydjiev SV, Klempt M, Kling E, Kunder S, Lengger C, Lisse T, Mijalski T, Naton B, Pedersen V, Prehn C, Przemeck G, Racz I, Reinhard C, Reitmeir P, Schneider I, Schrewe A, Steinkamp R, Zybill C, Adamski J, Beckers J, Behrendt H, Favor J, Graw J, Heldmaier G, Hofler H, Ivandic B, Katus H, Kirchhof P, Klingenspor M, Klopstock T, Lengeling A, Muller W, Ohl F, Ollert M, Quintanilla-Martinez L, Schmidt J, Schulz H, Wolf E, Wurst W, Zimmer A, Busch DH, De Angelis MH. Introducing the German Mouse Clinic: open access platform for standardized phenotyping. Nat Methods 2: 403-404, 2005 Pubmed
Jastroch M, Wuertz S, Kloas W, Klingenspor M. Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis. Physiol Genomics 22: 150-156, 2005 Pubmed
Kanzleiter T, Schneider T, Walter I, Bolze F, Eickhorst C, Heldmaier G, Klaus S, Klingenspor M. Evidence for NR4A1 as a cold-induced effector of brown fat thermogenesis. Physiol Genomics 24(1):37-44, 2005 Pubmed
Khorooshi RM, Klingenspor M. Neuronal distribution of melanin-concentrating hormone, cocaine- and amphetamine-regulated transcript and orexin B in the brain of the Djungarian hamster (Phodopus sungorus). J Chem Neuroanat 29: 137-148, 2005 Pubmed
Schuhmann B, Dietrich A, Sel S, Hahn C, Klingenspor M, Lommatzsch M, Gudermann T, Braun A, Renz H, Nockher WA. A role for brain-derived neurotrophic factor in B cell development. J Neuroimmunol 163: 15-23, 2005 Pubmed
2004
Berriel-Diaz M, Lange M, Heldmaier G, Klingenspor M. Depression of transcription and translation during daily torpor in the Djungarian hamster (Phodopus sungorus). J Comp Physiol [B] 174: 495-502, 2004 Pubmed
Jastroch M, Withers K, Klingenspor M. Uncoupling protein 2 and 3 in marsupials: identification, phylogeny, and gene expression in response to cold and fasting in Antechinus flavipes. Physiol Genomics 17: 130-139, 2004 Pubmed
Liebig M, von Praun C, Heldmaier G, Klingenspor M. Absence of UCP3 in brown adipose tissue does not impair nonshivering thermogenesis. Physiol Biochem Zool 77: 116-126, 2004 Pubmed
Meyer CW, Korthaus D, Jagla W, Cornali E, Grosse J, Fuchs H, Klingenspor M, Roemheld S, Tschöp M, Heldmaier G, De Angelis MH, Nehls M. A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity. Endocrinology 145: 2531-2541, 2004 Pubmed
Meyer CW, Klingenspor M, Rozman J, Heldmaier G. Gene or size: metabolic rate and body temperature in obese growth hormone-deficient dwarf mice. Obes Res 12: 1509-1518, 2004 Pubmed
Tups A, Helwig M, Khorooshi RM, Archer ZA, Klingenspor M, Mercer JG. Circulating ghrelin levels and central ghrelin receptor expression are elevated in response to food deprivation in a seasonal mammal ( Phodopus sungorus). J Neuroendocrinol 16: 922-928, 2004 Pubmed
Tups A, Ellis C, Moar KM, Logie TJ, Adam CL, Mercer JG, Klingenspor M. Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression. Endocrinology 145: 1185-1193, 2004 Pubmed
2003
Archer ZA, Rayner DV, Rozman J, Klingenspor M, Mercer JG. Normal distribution of body weight gain in male sprague-dawley rats fed a high-energy diet. Obes Res 11: 1376-1383, 2003 Pubmed
Hebebrand J, Exner C, Hebebrand K, Holtkamp C, Casper RC, Remschmidt H, Herpertz-Dahlmann B, Klingenspor M. Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia. Physiol Behav 79: 25-37, 2003 Pubmed
Klingenspor M. Cold-induced recruitment of brown adipose tissue thermogenesis. Exp Physiol 88: 141-148, 2003 Pubmed
Weitere Publikationen ...
Rousseau K, Atcha Z, Cagampang FR, Le Rouzic P, Stirland JA, Ivanov TR, Ebling FJ, Klingenspor M, Loudon AS. Photoperiodic regulation of leptin resistance in the seasonally breeding Siberian hamster (Phodopus sungorus). Endocrinology 143: 3083-3095, 2002 Pubmed
Weber K, Bruck P, Mikes Z, Kupper JH, Klingenspor M, Wiesner RJ. Glucocorticoid hormone stimulates mitochondrial biogenesis specifically in skeletal muscle. Endocrinology 143: 177-184, 2002 Pubmed
Boeuf S, Klingenspor M, Van Hal NL, Schneider T, Keijer J, Klaus S. 2001. Differential gene expression in white and brown preadipocytes. Physiol Genomics 7(1):15-25.
von Praun C, Burkert M, Gessner M, Klingenspor M. 2001. Tissue-specific expression and cold-induced mRNA levels of uncoupling proteins in the Djungarian hamster. Physiol Biochem Zool 74(2):203-11.
Atcha Z, Cagampang FR, Stirland JA, Morris ID, Brooks AN, Ebling FJ, Klingenspor M, Loudon AS. 2000. Leptin acts on metabolism in a photoperiod-dependent manner, but has no effect on reproductive function in the seasonally breeding Siberian hamster (Phodopus sungorus). Endocrinology 141(11):4128-35.
Exner C, Hebebrand J, Remschmidt H, Wewetzer C, Ziegler A, Herpertz S, Schweiger U, Blum WF, Preibisch G, Heldmaier G, Klingenspor M. 2000. Leptin suppresses semi-starvation induced hyperactivity in rats: implications for anorexia nervosa. Mol Psychiatry 5(5):476-81.
Klingenspor M, Niggemann H, Heldmaier G. 2000. Modulation of leptin sensitivity by short photoperiod acclimation in the Djungarian hamster, Phodopus sungorus. J Comp Physiol [B] 170(1):37-43.
Kronfeld-Schor N, Haim A, Dayan T, Zisapel N, Klingenspor M, Heldmaier G. 2000. Seasonal thermogenic acclimation of diurnally and nocturnally active desert spiny mice. Physiol Biochem Zool 73(1):37-44.
Heldmaier G, Klingenspor M, Werneyer M, Lampi BJ, Brooks SP, Storey KB. 1999. Metabolic adjustments during daily torpor in the Djungarian hamster. Am J Physiol 276(5 Pt 1):E896-E906.
Klingenspor M, Xu P, Cohen RD, Welch C, Reue K. 1999. Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics. J Biol Chem 274(33):23078-84.
Klingenspor M, Bodnar J, Welch C, Xia YR, Lusis AJ, Reue K. 1997. Localization of ubiquitin gene family members to mouse chromosomes 5, 11, and 18. Mamm Genome 8(10):789-90.
Klingenspor M, Bodnar J, Xia YR, Welch C, Lusis AJ, Reue K. 1997. Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs) to mouse chromosomes 11 and 15 respectively. Mamm Genome 8(7):539-40.
Kuusela P, Jacobsson A, Klingenspor M, Rehnmark S, Heldmaier G, Cannon B, Nedergaard J. 1997. Contrasting adrenergic effects on lipoprotein lipase gene expression in the brown adipose tissue of intact mice and in cultured brown adipocytes from mice. Biochim Biophys Acta 1345(3):327-37.
Klingenspor M, Dickopp A, Heldmaier G, Klaus S. 1996. Short photoperiod reduces leptin gene expression in white and brown adipose tissue of Djungarian hamsters. FEBS Lett 399(3):290-4.
Klingenspor M, Ivemeyer M, Wiesinger H, Haas K, Heldmaier G, Wiesner RJ. 1996. Biogenesis of thermogenic mitochondria in brown adipose tissue of Djungarian hamsters during cold adaptation. Biochem J 316 ( Pt 2):607-13.
Klingenspor M, Ebbinghaus C, Hulshorst G, Stohr S, Spiegelhalter F, Haas K, Heldmaier G. 1996. Multiple regulatory steps are involved in the control of lipoprotein lipase activity in brown adipose tissue. J Lipid Res 37(8):1685-95.
Meierfrankenfeld B, Abelenda M, Jauker H, Klingenspor M, Kershaw EE, Chua SC, Jr., Leibel RL, Schmidt I. 1996. Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats. Am J Physiol 270(4 Pt 1):E700-E708.
Klingenspor M, Meywirth A, Stohr S, Heldmaier G. 1994. Effect of unilateral surgical denervation of brown adipose tissue on uncoupling protein mRNA level and cytochrom-c-oxidase activity in the Djungarian hamster. J Comp Physiol [B] 163(8):664-70.
Bartsch C, Bartsch H, Buchberger A, Stieglitz A, Klingenspor M and Heldmaier G. Serial transplants of DMBA-induced mammary tumours in Fischer rats as model system for human breast cancer II.Analsysis of pineal melatonin biosynthesis and secretion. Advances Pin Res 30: 479-484, 1994.
Ruf TP, Klingenspor M, Preis H and Heldmaier G. Daily torpor in the Djungarian hamster (Phodopus sungorus): interactions with food intake, activity, and social behaviour. J Comp Physiol [B] 160: 609-615, 1991.
Heldmaier G, Steinlechner S, Ruf T, Wiesinger H, Klingenspor M. 1989. Photoperiod and thermoregulation in vertebrates: body temperature rhythms and thermogenic acclimation. J Biol Rhythms 4(2):251-65.
Klingenspor M, Klaus S, Wiesinger H, Heldmaier G. 1989. Short photoperiod and cold activate brown fat lipoprotein lipase in the Djungarian hamster. Am J Physiol 257(5 Pt 2):R1123-R1127.
Pädiatrische Ernährungsmedizin
2022
Masson E, Ewers M, Paliwal S, et al. The PRSS3P2 and TRY7 deletion copy number variant modifies risk for chronic pancreatitis. Pancreatology. 2022:S1424-3903(22)00822-5. doi: 10.1016/j.pan.2022.11.013. Online ahead of print. PMID: 36517351
Eiseler K, Dropmann LM, Bugert P, et al. Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis. Pancreatology. 2022;22(8):1079-1083. doi: 10.1016/j.pan.2022.09.240. PMID: 36167651
Wasnick R, Korfei M, Piskulak K, et al. Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis. Am J Respir Crit Care Med. 2022 Sep 1. doi: 10.1164/rccm.202105-1284OC. Online ahead of print. PMID: 36047984
Tóth A, Demcsák A, Zankl F, et al. Loss-of-function variant in chymotrypsin like elastase 3B (CELA3B) is associated with non-alcoholic chronic pancreatitis. Pancreatology. 2022;22(6):713-718. doi: 10.1016/j.pan.2022.06.258. PMID: 35773178
Takáts A, Berke G, Gede N, et al. Risk of chronic pancreatitis in carriers of loss-of-function CTRC variants: A meta-analysis. PLoS One. 2022;17(5):e0268859. doi: 10.1371/journal.pone.0268859. eCollection 2022. PMID: 35594281
Rygiel AM, Unger LS, Sörgel FL, et al. Variants in the pancreatic CUB and zona pellucida-like domains 1 (CUZD1) gene in early-onset chronic pancreatitis - A possible new susceptibility gene. Pancreatology. 2022;22(5):564-571. doi: 10.1016/j.pan.2022.04.015. PMID: 35589511
Schmidt AW, Kühnapfel A, Kirsten H, et al. Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms [published online ahead of print, 2022 Mar 11]. Pancreatology. 2022; S1424-3903(22)00096-5. doi:10.1016/j.pan.2022.03.007. PMID: 35331647
Ewers M, Epple D, Bugert P, Rosendahl J, Witt H. Genetic analysis of pancreatic phospholipase A2 (PLA2G1B) in patients with chronic pancreatitis. Pancreatology. 2022;22(2):244-247. doi:10.1016/j.pan.2022.01.003. PMID: 35031208
2021
Oracz G, Zaród M, Ewers M, et al. Loss of function TRPV6 variants are associated with chronic pancre-
atitis in nonalcoholic early-onset Polish and German patients. Pancreatology. 2021;21(8):1434-1442.
doi:10.1016/j.pan.2021.09.005. PMID: 34538581
Rosendahl J, Witt H. Pathogenese der chronischen Pankreatitis [Pathogenesis of chronic pancreatitis].
Internist (Berl). 2021;62(10):1007-1014. doi:10.1007/s00108-021-01150-6. PMID: 34524468
Ewers M, Canaff L, Weh AE, et al. The three common polymorphisms p.A986S, p.R990G and
p.Q1011E in the calcium sensing receptor (CASR) are not associated with chronic pancreatitis. Pan-
creatology. 2021;21(7):1299-1304. doi:10.1016/j.pan.2021.08.008. PMID: 34446336
2020
Seltsam K, Pentner C, Weigl F, Sutedjo S, Zimmer C, Beer S, Bugert P, Ewers M, Ruffert C, Michl P, Laumen H, Witt H, Rosendahl J. Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis. Pancreatology. 2020 Dec;20(8):1598-1603. doi: 10.1016/j.pan.2020.09.017. Epub 2020 Sep 29. PMID: 33036922. pubmed
Kaune T, Ruffert C, Hesselbarth N, Damm M, Krug S, Cardinal von Widdern J, Masson E, Chen JM, Rebours V, Buscail L, Férec C, Grützmann R, Te Morsche RHM, Drenth JP, Cavestro GM, Zuppardo RA, Saftoiu A, Malecka-Panas E, Głuszek S, Bugert P, Lerch MM, Sendler M, Weiss FU, Zou WB, Deng SJ, Liao Z, Scholz M, Kirsten H, Hegyi P, Witt H, Michl P, Griesmann H, Rosendahl J. Analysis of GPRC6A variants in different pancreatitis etiologies. Pancreatology. 2020 Oct;20(7):1262-1267. doi: 10.1016/j.pan.2020.08.001. Epub 2020 Aug 8. PMID: 32859544. pubmed
Masamune A, Kotani H, Sörgel FL, Chen JM, Hamada S, Sakaguchi R, Masson E, Nakano E, Kakuta Y, Niihori T, Funayama R, Shirota M, Hirano T, Kawamoto T, Hosokoshi A, Kume K, Unger L, Ewers M, Laumen H, Bugert P, Mori MX, Tsvilovskyy V, Weißgerber P, Kriebs U, Fecher-Trost C, Freichel M, Diakopoulos KN, Berninger A, Lesina M, Ishii K, Itoi T, Ikeura T, Okazaki K, Kaune T, Rosendahl J, Nagasaki M, Uezono Y, Algül H, Nakayama K, Matsubara Y, Aoki Y, Férec C, Mori Y, Witt H, Shimosegawa T. Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis. Gastroenterology. 2020 May;158(6):1626-1641.e8. doi: 10.1053/j.gastro.2020.01.005. Epub 2020 Jan 10. PMID: 31930989. pubmed
De Grandi A, Franzini M, Rosipal Š, Rosipal R, Debreova M, Corti A, Ruetzler-Dichtl E, Scholl-Bürgi S, Paolicchi A, Pompella A, Emdin M, Zampa G, Witt H, Zoller H, Tilg H, Mayatepek E, Herebian D, Pramstaller PP, Müller T, Janecke AR. Highly Elevated Plasma γ-Glutamyltransferase Elevations: A Trait Caused by γ-Glutamyltransferase 1 Transmembrane Mutations. Hepatology. 2020 Mar;71(3):1124-1127. doi: 10.1002/hep.30944. Epub 2019 Oct 28. PMID: 31520399. pubmed
Löhr JM, Beuers U, Vujasinovic M, Alvaro D, Frøkjær JB, Buttgereit F, Capurso G, Culver EL, de-Madaria E, Della-Torre E, Detlefsen S, Dominguez-Muñoz E, Czubkowski P, Ewald N, Frulloni L, Gu-bergrits N, Duman DG, Hackert T, Iglesias-Garcia J, Kartalis N, Laghi A, Lammert F, Lindgren F, Okhlobystin A, Oracz G, Parniczky A, Mucelli RMP, Rebours V, Rosendahl J, Schleinitz N, Schneider A, van Bommel EF, Verbeke CS, Vullierme MP, Witt H; UEG guideline working group. European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations. United European Gastroenterol J. 2020 Jul;8(6):637-666. doi: 10.1177/2050640620934911. Epub 2020 Jun 18. PMID: 32552502; PMCID: PMC7437085. pubmed
2019
Matejka K, Stückler F, Salomon M, Ensenauer R, Reischl E, Hoerburger L, Grallert H, Kastenmüller G, Peters A, Daniel H, Krumsiek J, Theis FJ, Hauner H, Laumen H. Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants. PLoS One. 2019;14(5):e0216110. doi: 10.1371/journal.pone.0216110. eCollection 2019. Pubmed
Lasher D, Szabó A, Masamune A, Chen JM, Xiao X, Whitcomb DC, Barmada MM, Ewers M, Ruffert C, Paliwal S, Issarapu P, Bhaskar S, Mani KR, Chandak GR, Laumen H, Masson E, Kume K, Hamada S, Nakano E, Seltsam K, Bugert P, Müller T, Groneberg DA, Shimosegawa T, Rosendahl J, Férec C, Lowe ME, Witt H, Sahin-Tóth M. Protease-sensitive pancreatic lipase variants are associated with early onset chronic pancreatitis. Am J Gastroenterol. 2019; doi: 10.14309/ajg.0000000000000051. Pubmed
Hedl M, Yan J, Witt H, Abraham C. IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome. J Immunol. 2019;202(3):920-930. doi: 10.4049/jimmunol.1800226. Pubmed
2018
Rosendahl J, Kirsten H, Hegyi E, Kovacs P, Weiss FU, Laumen H, Lichtner P, Ruffert C, Chen JM, Masson E, Beer S, Zimmer C, Seltsam K, Algül H, Bühler F, Bruno MJ, Bugert P, Burkhardt R, Cavestro GM, Cichoz-Lach H, Farré A, Frank J, Gambaro G, Gimpfl S, Grallert H, Griesmann H, Grützmann R, Hellerbrand C, Hegyi P, Hollenbach M, Iordache S, Jurkowska G, Keim V, Kiefer F, Krug S, Landt O, Leo MD, Lerch MM, Lévy P, Löffler M, Löhr M, Ludwig M, Macek M, Malats N, Malecka-Panas E, Malerba G, Mann K, Mayerle J, Mohr S, Te Morsche RHM, Motyka M, Mueller S, Müller T, Nöthen MM, Pedrazzoli S, Pereira SP, Peters A, Pfützer R, Real FX, Rebours V, Ridinger M, Rietschel M, Rösmann E, Saftoiu A, Schneider A, Schulz HU, Soranzo N, Soyka M, Simon P, Skipworth J, Stickel F, Strauch K, Stumvoll M, Testoni PA, Tönjes A, Werner L, Werner J, Wodarz N, Ziegler M, Masamune A, Mössner J, Férec C, Michl P, P H Drenth J, Witt H, Scholz M, Sahin-Tóth M; all members of the PanEuropean Working group on ACP. Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis. Gut. 2018 Oct;67(10):1855-1863. doi: 10.1136/gutjnl-2017-314454. Pubmed
Ebert K, Ewers M, Bisha I, Sander S, Rasputniac T, Daniel H, Antes I, Witt H. Identification of essential amino acids for glucose transporter 5 (GLUT5)-mediated fructose transport. J Biol Chem. 2018;293(6):2115-2124. doi: 10.1074/jbc.RA117.001442. Pubmed
Weiss FU, Hesselbarth N, Párniczky A, Mosztbacher D, Lämmerhirt F, Ruffert C, Kovacs P, Beer S, Seltsam K, Griesmann H, Böhme R, Kaune T, Hollenbach M, Schulz HU, Simon P, Mayerle J, Lerch MM, Cavestro GM, Zuppardo RA, Di Leo M, Testoni PA, Malecka-Panas E, Gasirowska A, Głuszek S, Bugert P, Szentesi A, Mössner J, Witt H, Michl P, Hégyi P, Scholz M, Rosendahl J. Common variants in the CLDN2-MORC4 and PRSS1-PRSS2 loci confer susceptibility to acute pancreatitis.Pancreatology. 2018. doi: 10.1016/j.pan.2018.05.486. [Epub ahead of print] Pubmed
Buchbeiträge und sonstige Veröffentlichungen | PEM | 2018
Dominguez-Munoz JE, Drewes AM, Lindkvist B, Ewald N, Czakó L, Rosendahl J, Löhr JM; HaPanEU/UEG Working Group. Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis. Pancreatology. 2018;18(8):847-854. doi: 10.1016/j.pan.2018.09.016. Review. Pubmed
Párniczky A, Abu-El-Haija M, Husain S, Lowe M, Oracz G, Sahin-Tóth M, Szabó FK, Uc A, Wilschanski M, Witt H, Czakó L, Grammatikopoulos T, Rasmussen IC, Sutton R, Hegyi P.EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis. Pancreatology. 2018;18(2):146-160. doi: 10.1016/j.pan.2018.01.001. Review. Pubmed (pdf-Datei)
2017
Rosendahl J, Kirsten H, Hegyi E, Kovacs P, Weiss FU, Laumen H, Lichtner P, Ruffert C, Chen JM, Masson E, Beer S, Zimmer C, Seltsam K, Algül H, Bühler F, Bruno MJ, Bugert P, Burkhardt R, Cavestro GM, Cichoz-Lach H, Farré A, Frank J, Gambaro G, Gimpfl S, Grallert H, Griesmann H, Grützmann R, Hellerbrand C, Hegyi P, Hollenbach M, Iordache S, Jurkowska G, Keim V, Kiefer F, Krug S, Landt O, Leo MD, Lerch MM, Lévy P, Löffler M, Löhr M, Ludwig M, Macek M, Malats N, Malecka-Panas E, Malerba G, Mann K, Mayerle J, Mohr S, Te Morsche RHM, Motyka M, Mueller S, Müller T, Nöthen MM, Pedrazzoli S, Pereira SP, Peters A, Pfützer R, Real FX, Rebours V, Ridinger M, Rietschel M, Rösmann E, Saftoiu A, Schneider A, Schulz HU, Soranzo N, Soyka M, Simon P, Skipworth J, Stickel F, Strauch K, Stumvoll M, Testoni PA, Tönjes A, Werner L, Werner J, Wodarz N, Ziegler M, Masamune A, Mössner J, Férec C, Michl P, P H Drenth J, Witt H, Scholz M, Sahin-Tóth M; all members of the PanEuropean Working group on ACP.Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.Gut. 2017. doi: 10.1136/gutjnl-2017-314454. [Epub ahead of print] Pubmed
Lee H, Qian K, von Toerne C, Hoerburger L, Claussnitzer M, Hoffmann C, Glunk V, Wahl S, Breier M, Eck F, Jafari L, Molnos S, Grallert H, Dahlman I, Arner P, Brunner C, Hauner H, Hauck SM, Laumen H.Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation.Nucleic Acids Res. 2017;45(6):3266-3279. doi: 10.1093/nar/gkx105. Pubmed
Witt H. [No Magic Bullet: Genetic Diagnostics and Predictive Testing].Dtsch Med Wochenschr. 2017;142(9):652-656. doi: 10.1055/s-0043-101829. German. Pubmed
Löhr JM, Dominguez-Munoz E, Rosendahl J, Besselink M, Mayerle J, Lerch MM, Haas S, Akisik F, Kartalis N, Iglesias-Garcia J, Keller J, Boermeester M, Werner J, Dumonceau JM, Fockens P, Drewes A, Ceyhan G, Lindkvist B, Drenth J, Ewald N, Hardt P, de Madaria E, Witt H, Schneider A, Manfredi R, Brøndum FJ, Rudolf S, Bollen T, Bruno M; HaPanEU/UEG Working Group.United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU).United European Gastroenterol J. 2017;5(2):153-199. doi: 10.1177/2050640616684695. Review. Pubmed
Ebert K, Ludwig M, Geillinger KE, Schoberth GC, Essenwanger J, Stolz J, Daniel H, Witt H.Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters.J Membr Biol. 2017;250(2):171-182. doi: 10.1007/s00232-016-9945-7. Pubmed
2016
Ebert K, Witt H.Fructose malabsorption.Mol Cell Pediatr. 2016;3(1):10. doi: 10.1186/s40348-016-0035-9. Pubmed
Mueller T, Fischer J, Gessner R, Rosendahl J, Böhm S, van Bömmel F, Knop V, Sarrazin C, Witt H, Marques AM, Kovacs P, Schleinitz D, Stumvoll M, Blüher M, Bugert P, Schott E, Berg T.Apolipoprotein E allele frequencies in chronic and self-limited hepatitis C suggest a protective effect of APOE4 in the course of hepatitis C virus infection.Liver Int. 2016;36(9):1267-74. doi: 10.1111/liv.13094. Pubmed
Szabó A, Pilsak C, Bence M, Witt H, Sahin-Tóth M.Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.J Biol Chem. 2016;291(34):17706-16. doi: 10.1074/jbc.M116.743237. Pubmed
Müller T, Rasool I, Heinz-Erian P, Mildenberger E, Hülstrunk C, Müller A, Michaud L, Koot BG, Ballauff A, Vodopiutz J, Rosipal S, Petersen BS, Franke A, Fuchs I, Witt H, Zoller H, Janecke AR, Visweswariah SS.Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C.Gut. 2016;65(8):1306-13. doi: 10.1136/gutjnl-2015-309441. Pubmed
Nestor CE, Lentini A, Hägg Nilsson C, Gawel DR, Gustafsson M, Mattson L, Wang H, Rundquist O, Meehan RR, Klocke B, Seifert M, Hauck SM, Laumen H, Zhang H, Benson M. 5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells. Cell Rep. 2016;16(2):559-570. doi: 10.1016/j.celrep.2016.05.091. Pubmed.
Strawbridge RJ, Laumen H, Hamsten A, Breier M, Grallert H, Hauner H, Arner P, Dahlman I.Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis.PLoS One. 2016;11(4):e0153990. doi: 10.1371/journal.pone.0153990. eCollection 2016. Pubmed
Song L, Wörmann S, Ai J, Neuhöfer P, Lesina M, Diakopoulos KN, Ruess D, Treiber M, Witt H, Bassermann F, Halangk W, Steiner JM, Esposito I, Rosendahl J, Schmid RM, Riemann M, Algül H.BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues.Gastroenterology. 2016;150(2):499-512.e20. doi: 10.1053/j.gastro.2015.10.017. Pubmed
Kirsten H, Scholz M, Kovacs P, Grallert H, Peters A, Strauch K, Frank J, Rietschel M, Nöthen MM, Witt H, Rosendahl J.Genetic variants of lipase activity in chronic pancreatitis.Gut. 2016;65(1):184-5. doi: 10.1136/gutjnl-2015-309521. Pubmed
Halama A, Horsch M, Kastenmüller G, Möller G, Kumar P, Prehn C, Laumen H, Hauner H, Hrabĕ de Angelis M, Beckers J, Suhre K, Adamski J.Metabolic switch during adipogenesis: From branched chain amino acid catabolism to lipid synthesis.Arch Biochem Biophys. 2016;589:93-107. doi: 10.1016/j.abb.2015.09.013. Pubmed
2015
Hoffmeister A, Mayerle J, Beglinger C, Büchler MW, Bufler P, Dathe K, Fölsch UR, Friess H, Izbicki J, Kahl S, Klar E, Keller J, Knoefel WT, Layer P, Loehr M, Meier R, Riemann JF, Rünzi M, Schmid RM, Schreyer A, Tribl B, Werner J, Witt H, Mössner J, Lerch MM; members of the guideline committee.English language version of the S3-consensus guidelines on chronic pancreatitis: Definition, aetiology, diagnostic examinations, medical, endoscopic and surgical management of chronic pancreatitis.Z Gastroenterol. 2015;53(12):1447-95. doi: 10.1055/s-0041-107379. Pubmed
Janecke AR, Heinz-Erian P, Yin J, Petersen BS, Franke A, Lechner S, Fuchs I, Melancon S, Uhlig HH, Travis S, Marinier E, Perisic V, Ristic N, Gerner P, Booth IW, Wedenoja S, Baumgartner N, Vodopiutz J, Frechette-Duval MC, De Lafollie J, Persad R, Warner N, Tse CM, Sud K, Zachos NC, Sarker R, Zhu X, Muise AM, Zimmer KP, Witt H, Zoller H, Donowitz M, Müller T.Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea.Hum Mol Genet. 2015;24(23):6614-23. doi: 10.1093/hmg/ddv367. Pubmed
Nakano E, Geisz A, Masamune A, Niihori T, Hamada S, Kume K, Kakuta Y, Aoki Y, Matsubara Y, Ebert K, Ludwig M, Braun M, Groneberg DA, Shimosegawa T, Sahin-Tóth M, Witt H.Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.Am J Physiol Gastrointest Liver Physiol. 2015;309(8):G688-94. doi: 10.1152/ajpgi.00241.2015. Pubmed
Derikx MH, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C, Lichtner P, Te Morsche RH, Cavestro GM, Férec C, Drenth JP, Witt H, Rosendahl J; PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators.Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.Gut. 2015;64(9):1426-33. doi: 10.1136/gutjnl-2014-307453. Pubmed
Fiamoncini J, Lima TM, Hirabara SM, Ecker J, Gorjão R, Romanatto T, ELolimy A, Worsch S, Laumen H, Bader B, Daniel H, Curi R.Medium-chain dicarboxylic acylcarnitines as markers of n-3 PUFA-induced peroxisomal oxidation of fatty acids.Mol Nutr Food Res. 2015;59(8):1573-83. doi: 10.1002/mnfr.201400743. Pubmed
Szabó A, Ludwig M, Hegyi E, Szépeová R, Witt H, Sahin-Tóth M.Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.J Biol Chem. 2015;290(28):17282-92. doi: 10.1074/jbc.M114.618439. Pubmed
Fjeld K, Weiss FU, Lasher D, Rosendahl J, Chen JM, Johansson BB, Kirsten H, Ruffert C, Masson E, Steine SJ, Bugert P, Cnop M, Grützmann R, Mayerle J, Mössner J, Ringdal M, Schulz HU, Sendler M, Simon P, Sztromwasser P, Torsvik J, Scholz M, Tjora E, Férec C, Witt H, Lerch MM, Njølstad PR, Johansson S, Molven A.A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis.Nat Genet. 2015;47(5):518-522. doi: 10.1038/ng.3249. Pubmed
Diakopoulos KN, Lesina M, Wörmann S, Song L, Aichler M, Schild L, Artati A, Römisch-Margl W, Wartmann T, Fischer R, Kabiri Y, Zischka H, Halangk W, Demir IE, Pilsak C, Walch A, Mantzoros CS, Steiner JM, Erkan M, Schmid RM, Witt H, Adamski J, Algül H.Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes.Gastroenterology. 2015;148(3):626-638.e17. doi: 10.1053/j.gastro.2014.12.003. Pubmed
2014
Prager M, Durmus T, Büttner J, Molnar T, de Jong DJ, Drenth JP, Baumgart DC, Sturm A, Farkas K, Witt H, Büning C.Myosin IXb variants and their pivotal role in maintaining the intestinal barrier: a study in Crohn's disease.Scand J Gastroenterol. 2014;49(10):1191-200. doi: 10.3109/00365521.2014.928903. Pubmed
Krinninger P, Ensenauer R, Ehlers K, Rauh K, Stoll J, Krauss-Etschmann S, Hauner H, Laumen H.Peripheral monocytes of obese women display increased chemokine receptor expression and migration capacity.J Clin Endocrinol Metab. 2014;99(7):2500-9. doi: 10.1210/jc.2013-2611. Pubmed
Ehlers K, Brand T, Bangert A, Hauner H, Laumen H.Postprandial activation of metabolic and inflammatory signalling pathways in human peripheral mononuclear cells.Br J Nutr. 2014;111(12):2167-75. doi: 10.1017/S0007114514000208. Epub 2014 Feb 28. Pubmed
Kretschmer A, Möller G, Lee H, Laumen H, von Toerne C, Schramm K, Prokisch H, Eyerich S, Wahl S, Baurecht H, Franke A, Claussnitzer M, Eyerich K, Teumer A, Milani L, Klopp N, Hauck SM, Illig T, Peters A, Waldenberger M, Adamski J, Reischl E, Weidinger S.A common atopy-associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding.Allergy. 2014;69(5):632-42. doi: 10.1111/all.12394. 2014 Mar 25. Pubmed
Sukalo M, Fiedler A, Guzmán C, Spranger S, Addor MC, McHeik JN, Oltra Benavent M, Cobben JM, Gillis LA, Shealy AG, Deshpande C, Bozorgmehr B, Everman DB, Stattin EL, Liebelt J, Keller KM, Bertola DR, van Karnebeek CD, Bergmann C, Liu Z, Düker G, Rezaei N, Alkuraya FS, Oğur G, Alrajoudi A, Venegas-Vega CA, Verbeek NE, Richmond EJ, Kirbiyik O, Ranganath P, Singh A, Godbole K, Ali FA, Alves C, Mayerle J, Lerch MM, Witt H, Zenker M.Mutations in the human UBR1 gene and the associated phenotypic spectrum.Hum Mutat. 2014;35(5):521-31. doi: 10.1002/humu.22538. Pubmed
Spieler D, Kaffe M, Knauf F, Bessa J, Tena JJ, Giesert F, Schormair B, Tilch E, Lee H, Horsch M, Czamara D, Karbalai N, von Toerne C, Waldenberger M, Gieger C, Lichtner P, Claussnitzer M, Naumann R, Müller-Myhsok B, Torres M, Garrett L, Rozman J, Klingenspor M, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Beckers J, Hölter SM, Meitinger T, Hauck SM, Laumen H, Wurst W, Casares F, Gómez-Skarmeta JL, Winkelmann J.Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.Genome Res. 2014;24(4):592-603. doi: 10.1101/gr.166751.113. Epub 2014 Mar 18. Pubmed
Wuensch T, Ullrich S, Schulz S, Chamaillard M, Schaltenberg N, Rath E, Goebel U, Sartor RB, Prager M, Büning C, Bugert P, Witt H, Haller D, Daniel H.Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.Inflamm Bowel Dis. 2014;20(4):671-84. doi: 10.1097/01.MIB.0000443336.71488.08. Pubmed
Schnúr A, Beer S, Witt H, Hegyi P, Sahin-Tóth M.Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.Gut. 2014;63(2):337-43. doi: 10.1136/gutjnl-2012-304331. Pubmed
Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium, Spieler D, Klingenspor M, Seifert M, Kern MJ, Mejhert N, Dahlman I, Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K, Hsu YH, Mellgren G, Hauner H, Laumen H.Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.Cell. 2014;156(1-2):343-58. doi: 10.1016/j.cell.2013.10.058. Pubmed
2013
van der Woerd WL, van Haaften-Visser DY, van de Graaf SF, Férec C, Masson E, Stapelbroek JM, Bugert P, Witt H, Houwen RH.Mutational analysis of ATP8B1 in patients with chronic pancreatitis.PLoS One. 2013;8(11):e80553. doi: 10.1371/journal.pone.0080553. eCollection 2013. Pubmed
Beer S, Zhou J, Szabó A, Keiles S, Chandak GR, Witt H, Sahin-Tóth M.Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.Gut. 2013;62(11):1616-24. doi: 10.1136/gutjnl-2012-303090. Pubmed
Then C, Wahl S, Kirchhofer A, Grallert H, Krug S, Kastenmüller G, Römisch-Margl W, Claussnitzer M, Illig T, Heier M, Meisinger C, Adamski J, Thorand B, Huth C, Peters A, Prehn C, Heukamp I, Laumen H, Lechner A, Hauner H, Seissler J.Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146.PLoS One. 2013;8(10):e78430. doi: 10.1371/journal.pone.0078430. eCollection 2013. Pubmed
Fischer J, Böhm S, Müller T, Witt H, Sarrazin C, Susser S, Migaud P, Schott E, Stewart G, Brodzinski A, Fülöp B, van Bömmel F, George J, Berg T.Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection.PLoS One. 2013;8(10):e77530. doi: 10.1371/journal.pone.0077530. eCollection 2013. Pubmed
Witt H, Beer S, Rosendahl J, Chen JM, Chandak GR, Masamune A, Bence M, Szmola R, Oracz G, Macek M Jr, Bhatia E, Steigenberger S, Lasher D, Bühler F, Delaporte C, Tebbing J, Ludwig M, Pilsak C, Saum K, Bugert P, Masson E, Paliwal S, Bhaskar S, Sobczynska-Tomaszewska A, Bak D, Balascak I, Choudhuri G, Nageshwar Reddy D, Rao GV, Thomas V, Kume K, Nakano E, Kakuta Y, Shimosegawa T, Durko L, Szabó A, Schnúr A, Hegyi P, Rakonczay Z Jr, Pfützer R, Schneider A, Groneberg DA, Braun M, Schmidt H, Witt U, Friess H, Algül H, Landt O, Schuelke M, Krüger R, Wiedenmann B, Schmidt F, Zimmer KP, Kovacs P, Stumvoll M, Blüher M, Müller T, Janecke A, Teich N, Grützmann R, Schulz HU, Mössner J, Keim V, Löhr M, Férec C, Sahin-Tóth M.Variants in CPA1 are strongly associated with early onset chronic pancreatitis.Nat Genet. 2013;45(10):1216-20. doi: 10.1038/ng.2730. Pubmed
Löhr JM, Dinter D, Diehl SJ, Haas SL, Veeser M, Pfützer R, Retter J, Schönberg SO, Düber C, Keim V, Schadendorf D, Witt H.Rapid progression of a splenic aneurysm due to segmental arterial mediolysis: a rare cause of acute pancreatitis.Pancreatology. 2013;13(5):553-6. doi: 10.1016/j.pan.2013.06.001. Pubmed
Mayerle J, Hoffmeister A, Werner J, Witt H, Lerch MM, Mössner J.Chronic pancreatitis--definition, etiology, investigation and treatment.Dtsch Arztebl Int. 2013;110(22):387-93. doi: 10.3238/arztebl.2013.0387. Pubmed
Rosendahl J, Landt O, Bernadova J, Kovacs P, Teich N, Bödeker H, Keim V, Ruffert C, Mössner J, Kage A, Stumvoll M, Groneberg D, Krüger R, Luck W, Treiber M, Becker M, Witt H.CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?Gut. 2013;62(4):582-92. doi: 10.1136/gutjnl-2011-300645. Pubmed
Mueller K, Quandt J, Marienfeld RB, Weihrich P, Fiedler K, Claussnitzer M, Laumen H, Vaeth M, Berberich-Siebelt F, Serfling E, Wirth T, Brunner C.Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB.Nucleic Acids Res. 2013;41(4):2138-54. doi: 10.1093/nar/gks1349. Epub 2013 Jan 4. Pubmed
Neuhöfer P, Liang S, Einwächter H, Schwerdtfeger C, Wartmann T, Treiber M, Zhang H, Schulz HU, Dlubatz K, Lesina M, Diakopoulos KN, Wörmann S, Halangk W, Witt H, Schmid RM, Algül H.Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A.Gastroenterology. 2013;144(1):192-201. doi: 10.1053/j.gastro.2012.09.058. Pubmed
2012
Hoffmeister A, Mayerle J, Dathe K, Mössner J, Lerch MM; Mitglieder der Leitlinienkommission.[Method report to the S3 guideline chronic pancreatitis: definition, etiology, diagnostics and conservative, interventional endoscopic and surgical therapy of the chronic pancreatitis].Z Gastroenterol. 2012;50(11):1225-36. doi: 10.1055/s-0032-1325447. Pubmed
Chronic Pancreatitis German Society of Digestive and Metabolic Diseases (DGVS), Hoffmeister A, Mayerle J, Beglinger C, Büchler MW, Bufler P, Dathe K, Fölsch UR, Friess H, Izbicki J, Kahl S, Klar E, Keller J, Knoefel WT, Layer P, Loehr M, Meier R, Riemann JF, Rünzi M, Schmid RM, Schreyer A, Tribl B, Werner J, Witt H, Mössner J, Lerch MM.[S3-Consensus guidelines on definition, etiology, diagnosis and medical, endoscopic and surgical management of chronic pancreatitis German Society of Digestive and Metabolic Diseases (DGVS)].Z Gastroenterol. 2012;50(11):1176-224. doi: 10.1055/s-0032-1325479. German. Pubmed.
Fischer J, Böhm S, Scholz M, Müller T, Witt H, George J, Sarrazin C, Susser S, Schott E, Suppiah V, Booth DR, Stewart GJ, van Bömmel F, Brodzinski A, Fülöp B, Migaud P, Berg T.Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection.Hepatology. 2012;55(6):1700-10. doi: 10.1002/hep.25582. Pubmed
Weis S, Jesinghaus M, Kovacs P, Schleinitz D, Schober R, Ruffert C, Herms M, Wittenburg H, Stumvoll M, Blüher M, Grützmann R, Schulz HU, Keim V, Mössner J, Bugert P, Witt H, Drenth JP, Krohn K, Rosendahl J.Genetic analyses of heme oxygenase 1 (HMOX1) in different forms of pancreatitis.PLoS One. 2012;7(5):e37981. doi: 10.1371/journal.pone.0037981. Pubmed
Löhr JM, Schneider A, Diehl SJ, Witt H.Opie's hypothesis revisited: acute pancreatitis due to bile reflux into the pancreas.Pancreatology. 2012;12(1):39-40. doi: 10.1016/j.pan.2011.12.001. Pubmed
Rosendahl J, Tönjes A, Schleinitz D, Kovacs P, Wiegand J, Ruffert C, Jesinghaus M, Schober R, Herms M, Grützmann R, Schulz HU, Stickel F, Werner J, Bugert P, Blüher M, Stumvoll M, Böhm S, Berg T, Wittenburg H, Mössner J, te Morsche R, Derikx M, Keim V, Witt H, Drenth JP.A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis.PLoS One. 2012;7(1):e29433. doi: 10.1371/journal.pone.0029433. Pubmed
2011
Krinninger P, Brunner C, Ruiz PA, Schneider E, Marx N, Foryst-Ludwig A, Kintscher U, Haller D, Laumen H, Hauner H.Role of the adipocyte-specific NF-κB activity in the regulation of IP-10 and T cell migration.Am J Physiol Endocrinol Metab. 2011;300(2):E304-11. doi: 10.1152/ajpendo.00143.2010. Pubmed
Boulling A, Witt H, Chandak GR, Masson E, Paliwal S, Bhaskar S, Reddy DN, Cooper DN, Chen JM, Férec C.Assessing the pathological relevance of SPINK1 promoter variants.Eur J Hum Genet. 2011;19(10):1066-73. doi: 10.1038/ejhg.2011.79. Pubmed
Steiner B, Rosendahl J, Witt H, Teich N, Keim V, Schulz HU, Pfützer R, Löhr M, Gress TM, Nickel R, Landt O, Koudova M, Macek M Jr, Farre A, Casals T, Desax MC, Gallati S, Gomez-Lira M, Audrezet MP, Férec C, des Georges M, Claustres M, Truninger K.Common CFTR haplotypes and susceptibility to chronic pancreatitis and congenital bilateral absence of the vas deferens.Hum Mutat. 2011;32(8):912-20. doi: 10.1002/humu.21511. Pubmed
Witt H.New modifier loci in cystic fibrosis.Nat Genet. 2011;43(6):508-9. doi: 10.1038/ng.844. Pubmed
Tiller G, Laumen H, Fischer-Posovszky P, Finck A, Skurk T, Keuper M, Brinkmann U, Wabitsch M, Link D, Hauner H.LIGHT (TNFSF14) inhibits adipose differentiation without affecting adipocyte metabolism.Int J Obes (Lond). 2011;35(2):208-16. doi: 10.1038/ijo.2010.126. Pubmed
2010
Rosendahl J, Teich N, Kovacs P, Szmola R, Blüher M, Gress TM, Hoffmeister A, Keim V, Löhr M, Mössner J, Nickel R, Ockenga J, Pfützer R, Schulz HU, Stumvoll M, Wittenburg H, Sahin-Tóth M, Witt H.Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis.Pancreatology. 2010;10(2-3):243-9. doi: 10.1159/000243769. Pubmed
van der Doef HP, Slieker MG, Staab D, Alizadeh BZ, Seia M, Colombo C, van der Ent CK, Nickel R, Witt H, Houwen RH.Association of the CLCA1 p.S357N variant with meconium ileus in European patients with cystic fibrosis.J Pediatr Gastroenterol Nutr. 2010;50(3):347-9. doi: 10.1097/MPG.0b013e3181afce6c. Pubmed
Witt H.Genetics of pancreatitis: a guide for clinicians.Dig Dis. 2010;28(6):702-8. doi: 10.1159/000324276. Review. Pubmed
Witt H, Rosendahl J, te Morsche RH, Santhosh S, Chacko A, Schulz HU, Landt O, Teich N, Keim V, Mössner J, Gress TM, Ockenga J, Schmidt H, Kovacs P, Blüher M, Stumvoll M, Kage A, Groneberg DA, Jansen JB, Nickel R, Drenth JP.Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis.Pancreas. 2010;39(2):188-92. doi: 10.1097/MPA.0b013e3181bd94ae. Pubmed2018
Weiss FU, Hesselbarth N, Párniczky A, Mosztbacher D, Lämmerhirt F, Ruffert C, Kovacs P, Beer S, Seltsam K, Griesmann H, Böhme R, Kaune T, Hollenbach M, Schulz HU, Simon P, Mayerle J, Lerch MM, Cavestro GM, Zuppardo RA, Di Leo M, Testoni PA, Malecka-Panas E, Gasirowska A, Głuszek S, Bugert P, Szentesi A, Mössner J, Witt H, Michl P, Hégyi P, Scholz M, Rosendahl J.Common variants in the CLDN2-MORC4 and PRSS1-PRSS2 loci confer susceptibility to acute pancreatitis.Pancreatology. 2018. doi: 10.1016/j.pan.2018.05.486. [Epub ahead of print] Pubmed
Párniczky A, Abu-El-Haija M, Husain S, Lowe M, Oracz G, Sahin-Tóth M, Szabó FK, Uc A, Wilschanski M, Witt H, Czakó L, Grammatikopoulos T, Rasmussen IC, Sutton R, Hegyi P.EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis.Pancreatology. 2018;18(2):146-160. doi: 10.1016/j.pan.2018.01.001. Review. Pubmed
Ebert K, Ewers M, Bisha I, Sander S, Rasputniac T, Daniel H, Antes I, Witt H.Identification of essential amino acids for glucose transporter 5 (GLUT5)-mediated fructose transport.J Biol Chem. 2018;293(6):2115-2124. doi: 10.1074/jbc.RA117.001442. Pubmed
2009
Hucl T, Kylanpää ML, Künzli B, Witt H, Lempinen M, Schneider A, Kemppainen E, Löhr M, Haas SL, Friess H, Ockenga J, Rosendahl J, Schulz HU, Gress T, Singer MV, Pfützer RH. Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis. Eur J Gastroenterol Hepatol. 2009 Mar 20. [Epub ahead of print] PubMed
Ockenga J, Strunck S, Post C, Schulz HU, Halangk J, Pfützer RH, Löhr M, Oettle H, Kage A, Rosendahl J, Keim V, Drenth JP, Jansen JB, Lochs H, Witt H. The Role of Epoxide Hydrolase Y113H Gene Variant in Pancreatic Diseases. Pancreas. 2009 Mar 12. [Epub ahead of print] PubMed
Zitnik SE, Rüschendorf F, Müller S, Sengler C, Lee YA, Griffioen RW, Meglio P, Wahn U, Witt H, Nickel R. IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis. Pediatr Allergy Immunol. 2009 Jan 31. [Epub ahead of print] PubMed
Beier KC, Humberdros S, Witt H, Illi S, Rüschendorf F, Nickel R, Lee YA, Lau S, Wahn U, Hamelmann E. ICOS-gene variants are not associated with atopic disease susceptibility in European children. Pediatr Allergy Immunol. 2009 Sep 26. [Epub ahead of print] PubMed
Sundaresan S, Chacko A, Dutta AK, Bhatia E, Witt H, Te Morsche RH, Jansen JB, Drenth JP. Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis. Pancreatology. 2009;9:145-149. PubMed
Rónai Z, Witt H, Rickards O, Destro-Bisol G, Bradbury AR, Sahin-Tóth M. A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). Biochem J. 2009;418:155-161. PubMed
2008
Halangk J, Sarrazin C, Neumann K, Puhl G, Müller T, Teuber G, Klinker H, Hinrichsen H, Buggisch P, Landt O, Weich V, Bergk A, Wiedenmann B, Neuhaus P, Berg T, Witt H. A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). J Hepatol. 2008;49:339-345. PubMed
O'Reilly DA, Witt H, Rahman SH, Schulz HU, Sargen K, Kage A, Cartmell MT, Landt O, Larvin M, Demaine AG, McMahon MJ, Becker M, Kingsnorth AN. The SPINK1 N34S variant is associated with acute pancreatitis. Eur J Gastroenterol Hepatol. 2008;20:726-731. PubMed
Witt H, Bhatia E. Genetic aspects of tropical calcific pancreatitis. Rev Endocr Metab Disord. 2008;9:213-226. Review. PubMed Artikel (pdf-Datei)
Von Hahn T, Halangk J, Witt H, Neumann K, Müller T, Puhl G, Neuhaus P, Nickel R, Beuers U, Wiedenmann B, Berg T. Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease. Scand J Gastroenterol. 2008;43:584-592. PubMed
Santhosh S, Witt H, te Morsche RH, Nemoda Z, Molnár T, Pap A, Jansen JB, Drenth JP. A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. Pancreas. 2008;36:317-320. PubMed
Büning C, Schmidt HH, Molnár T, Drenth JP, Fiedler T, Gentz E, Todorov T, Baumgart DC, Sturm A, Nagy F, Lonovics J, de Jong DJ, Landt O, Kage A, Nickel R, Büttner J, Lochs H, Witt H. No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn's disease: a study in 3 independent European cohorts. Inflamm Bowel Dis. 2008;14:332-337. PubMed
Schott E, Witt H, Neumann K, Bergk A, Halangk J, Weich V, Müller T, Puhl G, Wiedenmann B, Berg T. Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. J Viral Hepat. 2008;15:71-78. PubMed
Rosendahl J, Witt H, Szmola R, Bhatia E, Ozsvári B, Landt O, Schulz HU, Gress TM, Pfützer R, Löhr M, Kovacs P, Blüher M, Stumvoll M, Choudhuri G, Hegyi P, te Morsche RH, Drenth JP, Truninger K, Macek M Jr, Puhl G, Witt U, Schmidt H, Büning C, Ockenga J, Kage A, Groneberg DA, Nickel R, Berg T, Wiedenmann B, Bödeker H, Keim V, Mössner J, Teich N, Sahin-Tóth M. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet. 2008;40:78-82. PubMed Artikel (pdf-Datei)
Browning BL, Annese V, Barclay ML, Bingham SA, Brand S, Büning C, Castro M, Cucchiara S, Dallapiccola B, Drummond H, Ferguson LR, Ferraris A, Fisher SA, Gearry RB, Glas J, Henckaerts L, Huebner C, Knafelz D, Lakatos L, Lakatos PL, Latiano A, Liu X, Mathew C, Müller-Myhsok B, Newman WG, Nimmo ER, Noble CL, Palmieri O, Parkes M, Petermann I, Rutgeerts P, Satsangi J, Shelling AN, Siminovitch KA, Török HP, Tremelling M, Vermeire S, Valvano MR, Witt H. Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts. J Med Genet. 2008;45:36-42. PubMed
te Morsche RH, Drenth JP, Truninger K, Schulz HU, Kage A, Landt O, Verlaan M, Rosendahl J, Macek M Jr, Jansen JB, Witt H. UGT1A7 polymorphisms in chronic pancreatitis: an example of genotyping pitfalls. Pharmacogenomics J. 2008;8:34-41. PubMed
2007
Baumgart DC, Büning C, Geerdts L, Schmidt HH, Genschel J, Fiedler T, Gentz E, Molnár T, Nagy F, Lonovics J, Lochs H, Wiedenmann B, Nickel R, Witt H, Dignass A. The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease. Digestion. 2007;76:196-202. PubMed
Schott E, Witt H, Pascu M, van Boemmel F, Weich V, Bergk A, Halangk J, Müller T, Puhl G, Wiedenmann B, Berg T. Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease. Eur J Gastroenterol Hepatol. 2007;19:947-951. PubMed
Büning C, Schmidt HH, Molnar T, De Jong DJ, Fiedler T, Bühner S, Sturm A, Baumgart DC, Nagy F, Lonovics J, Drenth JP, Landt O, Nickel R, Büttner J, Lochs H, Witt H. Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis. Aliment Pharmacol Ther. 2007;26:1025-1033. PubMed
Hucl T, Kylanpää-Bäck ML, Witt H, Künzli B, Lempinen M, Schneider A, Kemppainen E, Löhr M, Friess H, Ockenga J, Rosendahl J, Schulz HU, Gress T, Singer MV, Pfützer RH. HFE genotypes in patients with chronic pancreatitis and pancreatic adenocarcinoma. Genet Med. 2007;9:479-483. PubMed
Müller S, Keil T, Grüber C, Zitnik SE, Lau S, Wahn U, Witt H, Nickel R. MBL2 variants in relation to common childhood infections and atopy-related phenotypes in a large German birth cohort. Pediatr Allergy Immunol. 2007;18:665-670. PubMed
Büning C, Durmus T, Molnar T, de Jong DJ, Drenth JPH, Fiedler T, Gentz E, Todorov T, Haas V, Buhner S, Sturm A, Baumgart DC, Nagy F, Lonovics J, Landt O, Kage A, Büning H, Nickel R, Büttner J, Lochs H, Schmidt HHJ, Witt H. A study in three European IBD cohorts confirms that the ATG16L1 c.898A>G (p.Thr300Ala) variant is a susceptibility factor for Crohn’s disease. Journal of Crohn's and Colitis 2007;1:70-76.
Schott E, Witt H, Neumann K, Taube S, Oh DY, Schreier E, Vierich S, Puhl G, Bergk A, Halangk J, Weich V, Wiedenmann B, Berg T. A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection. J Hepatol. 2007;47:203-211. PubMed
Witt H, Apte MV, Keim V, Wilson JS. Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology. 2007;132:1557-1573. Review. PubMed Artikel (pdf-Datei)
Király O, Boulling A, Witt H, Le Maréchal C, Chen JM, Rosendahl J, Battaggia C, Wartmann T, Sahin-Tóth M, Férec C. Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. Hum Mutat. 2007;28:469-476. PubMed
Schott E, Witt H, Hinrichsen H, Neumann K, Weich V, Bergk A, Halangk J, Müller T, Tinjala S, Puhl G, Neuhaus P, Wiedenmann B, Berg T. Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection. J Hepatol. 2007;46:372-380. PubMed
Markart P, Ruppert C, Wygrecka M, Schmidt R, Korfei M, Harbach H, Theruvath I, Pison U, Seeger W, Guenther A, Witt H. Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias. Eur Respir J. 2007;29:134-137. PubMed
2006
Treiber M, Schulz HU, Landt O, Drenth JP, Castellani C, Real FX, Akar N, Ammann RW, Bargetzi M, Bhatia E, Demaine AG, Battagia C, Kingsnorth A, O'Reilly D, Truninger K, Koudova M, Spicak J, Cerny M, Menzel HJ, Moral P, Pignatti PF, Romanelli MG, Rickards O, De Stefano GF, Zarnescu NO, Choudhuri G, Sikora SS, Jansen JB, Weiss FU, Pietschmann M, Teich N, Gress TM, Ockenga J, Schmidt H, Kage A, Halangk J, Rosendahl J, Groneberg DA, Nickel R, Witt H. Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer. J Mol Med. 2006;84:1015-1022. PubMed
Witt H, Sahin-Tóth M, Landt O, Chen JM, Kähne T, Drenth JP, Kukor Z, Szepessy E, Halangk W, Dahm S, Rohde K, Schulz HU, Le Maréchal C, Akar N, Ammann RW, Truninger K, Bargetzi M, Bhatia E, Castellani C, Cavestro GM, Cerny M, Destro-Bisol G, Spedini G, Eiberg H, Jansen JB, Koudova M, Rausova E, Macek M Jr, Malats N, Real FX, Menzel HJ, Moral P, Galavotti R, Pignatti PF, Rickards O, Spicak J, Zarnescu NO, Böck W, Gress TM, Friess H, Ockenga J, Schmidt H, Pfützer R, Löhr M, Simon P, Weiss FU, Lerch MM, Teich N, Keim V, Berg T, Wiedenmann B, Luck W, Groneberg DA, Becker M, Keil T, Kage A, Bernardova J, Braun M, Güldner C, Halangk J, Rosendahl J, Witt U, Treiber M, Nickel R, Férec C. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. Nat Genet. 2006;38:668-673. PubMed Artikel (pdf-Datei)
Büning C, Geerdts L, Fiedler T, Gentz E, Pitre G, Reuter W, Luck W, Bühner S, Molnár T, Nagy F, Lonovics J, Dignass A, Landt O, Nickel R, Genschel J, Lochs H, Schmidt HH, Witt H. DLG5 variants in inflammatory bowel disease. Am J Gastroenterol. 2006;101:786-792. PubMed
1999-2005
Frerking I, Sengler C, Günther A, Walmrath HD, Stevens P, Witt H, Landt O, Pison U, Nickel R. Evaluation of the -26G>A CC16 polymorphism in acute respiratory distress syndrome. Crit Care Med. 2005;33:2404-2406. PubMed
Perrot A, Schmidt-Traub H, Hoffmann B, Prager M, Bit-Avragim N, Rudenko RI, Usupbaeva DA, Kabaeva Z, Imanov B, Mirrakhimov MM, Witt H, Dietz R, Wycisk A, Tendera M, Gessner R, Osterziel KJ. Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy. J Mol Med 2005;83:468-477 (erratum: J Mol Med 2005;83:837).
Verlaan M, Drenth JP, Truninger K, Koudova M, Schulz HU, Bargetzi M, Künzli B, Friess H, Cerny M, Kage A, Landt O, te Morsche RH, Rosendahl J, Luck W, Nickel R, Halangk J, Becker M, Macek M Jr, Jansen JB, Witt H. Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases. J Med Genet. 2005;42:e62. PubMed
Müller T, Mas-Marques A, Sarrazin C, Wiese M, Halangk J, Witt H, Ahlenstiel G, Spengler U, Goebel U, Wiedenmann B, Schreier E, Berg T. Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection. J Hepatol. 2004;41:652-658. PubMed
Büning C, Halangk J, Dignass A, Ockenga J, Deindl P, Nickel R, Genschel J, Landt O, Lochs H, Schmidt H, Witt H. Keratin 8 Y54H and G62C mutations are not associated with inflammatory bowel disease. Dig Liver Dis. 2004;36:388-391. PubMed
Halangk J, Berg T, Puhl G, Mueller T, Nickel R, Kage A, Landt O, Luck W, Wiedenmann B, Neuhaus P, Witt H. Keratin 8 Y54H and G62C mutations are not associated with liver disease. J Med Genet. 2004;41:e92. PubMed
Groneberg DA, Witt H, Adcock IM, Hansen G, Springer J. Smads as intracellular mediators of airway inflammation. Exp Lung Res. 2004;30:223-250. Review. PubMed
Belkind-Gerson J, Fernandez-Peters A, Furnes R, Oliver M, Perrault J, Robertson M, Witt H; Latin American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Pancreatic disorders and cystic fibrosis: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2004;39 Suppl 2:S688-694. Review. PubMed
Witt H, Neumann LM, Grollmuss O, Luck W, Becker M. Prenatal diagnosis of Alagille syndrome. J Pediatr Gastroenterol Nutr. 2004;38:105-106. PubMed
Müller T, Geßner R, Sarrazin C, Graf C, Halangk J, Witt H, Köttgen E, Wiedenmann B, Berg T. Apolipoprotein E4 allele is associated with poor treatment response in hepatitis C virus (HCV) genotype 1. Hepatology. 2003;38:1592. PubMed
Bhatia E, Kordonouri O, Balasubramanium K, Rajeswari J, Landt O, Simon P, Lerch MM, Witt H. Absence of association between SPINK1 trypsin inhibitor mutations and Type 1 or 2 diabetes mellitus in India and Germany. Diabetologia. 2003;46:1710-1711. PubMed
Beranek H, Teich N, Witt H, Schulz HU, Mössner J, Keim V. Analysis of tumour necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancreatitis. Eur J Gastroenterol Hepatol. 2003;15:1223-1227. PubMed
Keim V, Witt H, Bauer N, Bödeker H, Rosendahl J, Teich N, Mössner J. The course of genetically determined chronic pancreatitis. JOP. 2003;4:146-154. PubMed
Weiss FU, Simon P, Witt H, Mayerle J, Hlouschek V, Zimmer KP, Schnekenburger J, Domschke W, Neoptolemos JP, Lerch MM. SPINK1 mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutations. J Med Genet. 2003;40:e40. PubMe
Witt H. Chronic pancreatitis and cystic fibrosis. Gut. 2003;52 Suppl 2:ii31-41. Review. PubMed
Teich N, Schulz HU, Witt H, Böhmig M, Keim V. N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer. Pancreatology. 2003;3:67-68. PubMed
Müller T, van de Sluis B, Zhernakova A, van Binsbergen E, Janecke AR, Bavdekar A, Pandit A, Weirich-Schwaiger H, Witt H, Ellemunter H, Deutsch J, Denk H, Müller W, Sternlieb I, Tanner MS, Wijmenga C. The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis. J Hepatol. 2003;38:164-168. PubMed
Bhatia E, Choudhuri G, Sikora SS, Landt O, Kage A, Becker M, Witt H. Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. Gastroenterology. 2002;123:1020-1025. PubMed
Truninger K, Witt H, Köck J, Kage A, Seifert B, Ammann RW, Blum HE, Becker M. Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis. Am J Gastroenterol. 2002;97:1133-1137. PubMed
Witt H. The SPINK in chronic pancreatitis: similar finds, different minds. Gut. 2002;50:590-591. PubMed
Witt H, Kage A, Luck W, Becker M. Alpha1-antitrypsin genotypes in patients with chronic pancreatitis. Scand J Gastroenterol. 2002;37:356-359. PubMed
Witt H, Becker M. Genetics of chronic pancreatitis. J Pediatr Gastroenterol Nutr. 2002;34:125-136. Review. PubMed
Witt H. Gene mutations in children with chronic pancreatitis. Pancreatology. 2001;1:432-438. Review. PubMed
Truninger K, Ammann RW, Blum HE, Witt H. Genetic aspects of chronic pancreatitis: insights into aetiopathogenesis and clinical implications. Swiss Med Wkly. 2001;131:565-574. Review. PubMed
Witt H, Landt O. Rapid detection of the Wilson's disease H1069Q mutation by melting curve analysis with the LightCycler. Clin Chem Lab Med. 2001;39:953-955. PubMed
Witt H, Simon P, Lerch MM. [Genetic aspects of chronic pancreatitis]. Dtsch Med Wochenschr. 2001;126:988-993. Review. PubMed
Witt H, Luck W, Becker M, Böhmig M, Kage A, Truninger K, Ammann RW, O'Reilly D, Kingsnorth A, Schulz HU, Halangk W, Kielstein V, Knoefel WT, Teich N, Keim V. Mutation in the SPINK1 trypsin inhibitor gene, alcohol use, and chronic pancreatitis. JAMA. 2001;285:2716-2717. PubMed
Witt H, Hennies HC, Becker M. SPINK1 mutations in chronic pancreatitis. Gastroenterology. 2001;120:1060-1061. PubMed
Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, Landt O, Becker M. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet. 2000;25:213-216. PubMed
Maier RF, Witt H, Bührer C, Mönch E, Köttgen E. HFE gene mutation and transferrin saturation in very low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 1999;81:F144-145. PubMed
Witt H, Luck W, Becker M. A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis. Gastroenterology. 1999;117:7-10. PubMed